Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Synaptogenesis"”.
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Imaging Neuromuscular Synaptogenesis
Successful synaptogenesis requires collaboration of cellular and molecular dynamics. Whereas synaptic matchmaking relies on cell-specific recognition molecules, subsequent synaptogenesis requires proteins that are common to a given synaptic type. Biochemical studies reveal that PSD-95/Dlg family …
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Analysis of Postsynaptic Morphology During Neuromuscular Synaptogenesis in Drosophila Melanogaster
"The successful construction of a functional neuronetwork requires that precise connections be made between vast numbers of individual cells. Pre- and postsynaptic cells use a variety of molecular cues to recognize one another. Changes in presynaptic cell morphology during encounters with these …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… contact. Motoneurons fail to initiated synaptogenesis in commissureless mutants and resupplying wildtype commissureless back to commissureless null muscles restores motoneuron synaptogenesis. Misexpression of a cytoplasmically truncated commissureless construct in muscles functions as a …
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Membrane-bound Matrix Metalloproteinases Influence Reactive Synaptogenesis Following Traumatic Brain Injury
… and deafferentation, triggering injury-induced synaptogenesis, a process influenced by matrix metalloproteinases (MMP) and their substrates. Here we report results of studies examining the expression and potential role of two membrane-bound MMPs, membrane-type 5-MMP (MT5-MMP) and a disintegrin …
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Ethanol exposure during synaptogenesis in a mouse model of fetal alcohol spectrum disorders: acute and long-term effects on gene expression and behaviour
… a binge-like exposure to ethanol during synaptogenesis, a period of neurodevelopment characterized by the rapid formation and pruning of synaptic connectivity that correlates to brain development during the human third trimester. B6 pups were treated with a high dose (5 g/kg over 2 hours) …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… Growing evidence indicates that deficits in synaptogenesis and impaired signaling mediated by the insulin receptor and insulin-like growth factor 1 (IGF1) receptors underlies the pathogenesis of intellectual disability. NCAM2 is enriched at excitatory synapses and is involved in synapse …
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Effects of MDGA2 Reduction on Synaptic Long-Term Depression and Development in Male Mice
… synapse organizer, restricts excitatory synaptogenesis by inhibiting neurexin-neuroligin adhesion complexes and BDNF/TrkB signaling. Mdga2+/- mice, modeling autism-associated mutations, show increased excitatory synapse density and hyperexcitation in adulthood, resulting in altered …
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Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
… and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP …
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Μελέτη της συναπτογενέσεως του ακουστικού φλοιού in vitro άνευ και κατόπιν ηλεκτρικού ερεθισμού ανάλογου προς τα ηλεκτρικά δυναμικά ενέργειας του κοχλιακού νεύρου
The synaptogenesis and the neuronal interactions of the rat's acoustic cortex were studied in explants cultured in vitro, exposed to a continuous sound of a certain frequency. The morphological findings were correlated morphologically with explants of the same area of the cortex from the same …
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Mechanisms of Synapse Formation and Synaptic Plasticity
… machinery. However, the precise time course of synaptogenesis, and the role of extrinsic factors in synapse formation remains unclear. To examine the time course of synaptogenesis, I developed a novel “growth ball” model to study synapse at the level of isolated growth cones. Specifically, I …
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Regulation of filopodia dynamics is critical for proper synapse formation
Despite the importance of proper synaptogenesis in the CNS, the molecular mechanisms that regulate the formation and development of synapses remain poorly understood. Indeed, the mechanisms through which initial synaptic contacts are established and modified during synaptogenesis have not been …
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INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
… spatial-temporal changes were observed in early synaptogenesis within the FEZ1-null organoids. Thus, we uncover FEZ1’s importance during early forebrain development. These findings potentially contribute to the understanding of neural developmental pathologies and origins of neuropsychiatric …
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Axon Guidance Autonomy and Tensional Requirement for Synaptic Function: Is Learning a Forced Response
… growth cones as they navigate and initiate synaptogenesis, while implicating intercellular tension as a novel ""retrograde"" mechanism to adjust synaptic function."
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Building a Consistent Neuronetwork: Defining Molecular Cues Involved in the Synaptic Target Recognition of Drosophila Melanogaster
"Every synaptogenesis begins with ""synaptic target recognition"", a cell-cell recognition event in which a neuron and its target stably adhere. Herein I describe two transmembrane molecules present on a subset of muscles in the Drosophila embryonic neuromuscular system, Fas3 and Toll, that affect …
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Structural dynamics and synaptic development in the visual system
… excitatory synaptic contacts, during a period of synaptogenesis in the developing mouse cortex. The second study extends these findings and examines the properties of dendritic spines during a period of heightened visual cortical plasticity and describes how manipulations of visual input alter …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… such as dendritic arborization, spinogenesis and synaptogenesis are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel …
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Neuronal filopodia borne along tips and shafts of dendrites comprise two distinct populations as evidenced by differences in structure and dynamics
… studies into their morphogenesis, and into synaptogenesis, brought into the spotlight their putative precursors – the dendritic filopodia. This set off several lines of investigation into filopodial structure and function, notable among which is the work by Portera-Cailliau et al. who showed …
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
… use disorder convergently dysregulates both synaptogenesis and angiogenesis through perturbation of the PI3K/Akt and MAPK/Erk second messenger systems and dysregulation of immediate early genes. The mechanistic insights from these human models may aid the discovery of novel pharmaceutical …
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