Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Synaptic plasticity and memory"”.
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… is a major brain modulatory system that controls memory and learning mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic plasticity and behavior. CB1 …
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A role for the SHANK1 scaffold protein in experience-induced synaptic plasticity and memory consolidation
… processes by which the brain acquires, stores, and retrieves external information has been an extensively researched field in psychology. Findings from these studies have overwhelmingly suggested that plasticity of neuroanatomical networks across development and during various experiences …
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A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… neurodegenerative disorder affecting the elderly and characterized by memory loss, personality changes and cognitive dysfunction leading to dementia. I will discuss the main projects in which I participated aimed at understanding the role of the main molecular interactors involved in AD …
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Amyloid-beta signaling in physiology and pathology: from astrocytes to SUMO
… characterized clinically by progressive dementia and histopathologically by amyloid plaques and neurofibrillary tangles. The primary molecular culprit in AD is the amyloid-beta (Abeta) peptide, aggregates of which are the main components of the plaques. Numerous studies have implicated soluble …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… of evidence that Cdk5 plays a critical role in synaptic function and plasticity. First, we characterized the function of Cdk5 in learning and memory by region-specific Cdk5 ablation. From multiple Cdk5 conditional knockout mouse models, we determined that Cdk5 is essential for memory formation …
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Alpha Synuclein Oligomers in Human Pathology: Significance of Nitrative Alpha Synuclein Modifications
… synucleinopathies such as Parkinson disease (PD) and dementia with Lewy bodies (DLB), which are clinically characterized by motor and cognitive dysfunction. Recent evidence indicates that αSyn oligomer intermediates are the most neurotoxic species. However, the mechanism of action of αSyn …
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Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
… connectivity between prefrontal-amygdala and hippocampus, all of which is associated with an increased risk of experiencing a traumatic event again later in life. While clinical research has increasingly stressed the importance in addressing the long-lasting consequences of ELA, treatment …
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Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
… acid receptors (AMPARs) are ligand-gated glutamatergic ion channels that mediate most excitatory neurotransmission in the brain. Alterations in AMPAR synaptic accumulation mediate synaptic plasticity, including long-term potentiation, long-term depression and homeostatic synaptic …