Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Synaptic inhibition"”.
-
Modulation of hippocampal synaptic transmission by the peptide diazepam binding inhibitor and optogenetic manipulation of astrocytes
Hippocampal synaptic transmission is an intricate and flexible entity that can be modulated, both directly and indirectly, by a variety of different signaling molecules and cell types. The peptide diazepam binding inhibitor (DBI) has complex physiological functions and is capable of both enhancing …
-
Circadian Timekeeping of Body Temperature by the Mammalian Suprachiasmatic Nucleus
… of a month in constant darkness. Interestingly, synaptic inhibition of a subpopulation of these Nms neurons co-expressing arginine vasopressin lengthened the circadian period of CRT. Finally, local chemogenetic inhibition of the SCN Nms neurons prevented hypothermia specifically during the late …
-
Exploring the determinants of chloride homeostasis in neurons using biophysical models
Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl ions via activated GABAA and glycine receptors. As a result, changes to the neuronal driving force for Cl- are thought to play pivotal roles in many physiological and pathological brain processes. Established …
-
Cellular and Circuit Properties of Slow Oscillations In The Thalamic Reticular Nucleus
… of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory thalamic nuclei underlie the generation of sleep spindles, the mechanisms regulating slow (<1 >Hz) forms of thalamic oscillations are poorly understood. Under <em>in vitro</em> conditions, in the absence of …
-
Novel roles of the endocannabinoid system in modulating synaptic plasticity
… control these phenomena are largely unknown. Synaptic plasticity, which is the ability of the synapse between two neurons to change in strength based on activity, is believed to be a key process in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as …
-
Novel roles of the endocannabinoid system in modulating synaptic plasticity
… control these phenomena are largely unknown. Synaptic plasticity, which is the ability of the synapse between two neurons to change in strength based on activity, is believed to be a key process in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as …
-
Loss of synchrony in an inhibitory network of type-I oscillators
… of excitable cells coupled by reciprocal inhibition is a topic of significant interest due to the important role that inhibitory synaptic interaction plays in the generation and regulation of coherent rhythmic activity in a variety of neural systems. While recent work revealed the …
-
Endogenous neurosteroid actions at GABAA receptors during neuronal development
… receptors (GABAARs) mediate the majority of fast inhibition in the CNS and as such are crucial to neuronal function. Two distinct modes of GABAAR mediated inhibition exist: “phasic” involves the transient activation of postsynaptic GABAARs following presynaptic vesicular GABA release and “tonic” …
-
Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
… Therefore, the superfamily mediates both fast synaptic excitation and inhibition and is the sole source of fast synaptic inhibition in the nervous system of animals. This phenomenon of charge selectivity has been studied in pLGICs for many years, but the molecular details of how these channels …
-
The risk and severity of preeclampsia secondary to iodine deficiency and iodine deficiency-mediated subclinical hypothyroidism: mechanisms and early cardiovascular consequences
… attenuates GABAB receptor mediated tonic extra-synaptic inhibition resulting in net motor neurone stimulation and increased predisposition to the involuntary tonic-clonic convulsions observed in eclampsia. Conclusion There is still a high prevalence of inadequate iodine intake in pregnancy in …