Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Synaptic depression"”.
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Potential for change: Characterizing synaptic plasticity following visual discrimination learning in adult rats.
Synaptic plasticity (long-term potentiation, LTP and long-term depression, LTD) plays an important role in processes of learning and memory formation. In order to provide a link between these neurophysiological and cognitive processes the following experiments were performed using behavioral, …
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Dopamine and the Temporal Dependence of Learning and Memory
… signals is encoded at the molecular, synaptic, and circuit level to give rise to learned odor associations. I show that in Drosophila, opposing olfactory associations can be formed and updated on a trial-by-trial basis depending on the temporal relationship between an odor cue and …
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The role of short term synamptic plasticity in temporal coding of neuronal networks
Short term synaptic plasticity is a phenomenon which is commonly found in the central nervous system. It could contribute to functions of signal processing namely, temporal integration and coincidence detection by modulating the input synaptic strength. This dissertation has two parts. First we …
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A Study on an FMRP-Mediated Translational Switch in the MGluR-Triggered Translation of Arc and Synaptic Plasticity
… protein synthesis and long-term synaptic depression (mGluR-LTD) are altered in a mouse model of Fragile X Syndrome, Fmr1 knockout (KO) mouse. Fmr1 encodes the Fragile X mental retardation protein (FMRP), a dendritic RNA-binding protein that functions, in part, as a translational …
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Mechanisms Mediating Adaptive Presynaptic Muting Induction
… excitatory neurotransmitter release from presynaptic terminals. The mechanisms responsible for inducing this presynaptic silencing: or "muting"), however, have been elusive. In order to elucidate the signals responsible, I used molecular techniques in defined networks of cultured neurons from …
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Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome
… receptors (mGluR1, mGluR5) induces long-term synaptic depression (LTD) that requires rapid, dendritic protein synthesis. The significance of protein synthesis-dependent mGluR LTD to cognitive function is highlighted by the recent finding that mGluR-dependent LTD is enhanced and protein …
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Using feed-forward networks to infer the activity of feedback neuronal networks
… coupled heterogenous neurons, A and B, with synaptic depression from neuron A to neuron B. Suppose we are given two pieces of feed-forward information, the effect of neuron A on the activity of neuron B in the feed-forward network of A entraining B and vice versa. Moreover, suppose these …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… responses rapidly weaken through homosynaptic long-term depression (LTD). As the period of deprivation progresses, the modification threshold determining the boundary between synaptic depression and synaptic potentiation becomes lower via a decrease in the ratio of NR2A to NR2B …
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Age-dependent regulation of hippocampal excitatory synaptic transmission by leptin
… leptin is a diverse regulator of hippocampal synaptic function (Irving and Harvey, 2014). Previous studies demonstrate that leptin can regulate hippocampal excitatory synaptic transmission in an age-dependent manner at Schaffer collateral (SC)-CA1 synapses (Moult and Harvey, 2011). In …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… nervous system, mediating fast excitatory synaptic transmission. Their distribution and activity are regulated by post-translational modifications, such as ubiquitination and phosphorylation. Studies have shown that GluA1 ubiquitination contributes to its internalization, which, as part of …