Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1145 for “"Synaptic"”.
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Exploring Synaptic Vesicle Exocytosis
… optical techniques to study determinants of presynaptic efficiency. Our methods are largely based on a chimera of a pH-sensitive variant of the green fluorescent protein and the vesicular glutamate transporter. This reporter is incorporated into synaptic vesicles and increases its fluorescence …
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Dissecting Synaptic Vesicle Endocytosis
<p>Synaptic vesicle endocytosis is critical for ensuring rapid local recycling of synaptic vesicles to enable ongoing neuronal activity. We utilized the sensitivity and robustness of the pHluorin assay of synaptic vesicle recycling to probe the control of endocytosis spatially and in response to …
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Ca2+ dependant synaptic modification
… LTP have been 1. tetanic stimulation of presynaptic cell, 2. theta burst stimulation of presynaptic cell, and 3. correlated stimulation of pre- and post-synaptic cells. However, the effects of different Ca2+ influx can not be precisely dissected with the conventional protocols for the …
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An investigation into the synaptic conditions and celluar mechanisms underlying cerebellar synaptic plasticity
The direction of synaptic plasticity at the connection between parallel fibres (PFs) and Purkinje cells can be modified by PF stimulation alone. Strong activation (Hartell, 1996) or high frequency stimulation (Schreurs and Alkon, 1993) of PFs induced a long-term depression (LTD) of PF-mediated …
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Molecular mechanisms of synaptic proteins
Synaptic adhesion molecules (SAMs) are critical for regulating synapse development and synaptic plasticity. Many studies have linked their putative roles in neuropsychiatric and neurodevelopmental diseases, such as schizophrenia and autism spectrum disorder. Here, the structure-function …
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Calcium Triggered Synaptic Vesicle Exocytosis
… questions in neuroscience is how Ca 2+ promotes synaptic vesicles from rest to fusion leading to release of neurotransmitters. In this thesis, I first addressed if synaptogmin-1/SNARE binding is important for synaptic vesicle release. Using two knock-in mouse lines each with single amino-acid …
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Molecular mechanisms of synaptic proteins
Synaptic adhesion molecules (SAMs) are critical for regulating synapse development and synaptic plasticity. Many studies have linked their putative roles in neuropsychiatric and neurodevelopmental diseases, such as schizophrenia and autism spectrum disorder. Here, the structure-function …
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Immunological investigations into synaptic plasticity
Antibody technology was applied to the study of synaptic plasticity resulting from passive avoidance training in the chick and long-term potentiation in the rat. These studies fell into three categories: 1) the disruption of memory for a one-trial passive avoidance task by intracranial injection of …
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Visualizing Synaptic Specificity with GRASP
… precision as it selects a unique ensemble of synaptic partners from a vast array of potential targets. Visualization of individual synapses in the central nervous system is difficult in some contexts and impossible in others, and the ability to rapidly monitor connectivity in living animals …
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Molecular mechanisms of synaptic plasticity
Synaptic plasticity serves as a central molecular mechanism underlying learning and memory formation in the brain. An increase in intracellular calcium concentrations triggered by neuronal activity induces synaptic plasticity, and calmodulin is a key protein that detects the elevated calcium levels …
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Genetic Dissection of Synaptic Vesicle Endocytosis
Synaptic transmission is mediated by the quantal release of neurotransmitters through the fusion of discrete synaptic vesicles with the presynaptic membrane. To maintain reliable transmission, synaptic vesicles and proteins must be recycled after release of neurotransmitters. A key protein in this …
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Induction and Maintenance of Synaptic Plasticity
Synaptic long-term modifications following neuronal activation are believed to be at the origin of learning and long-term memory. Recent experiments suggest that these long-term synaptic changes are all-or-none switch-like events between discrete states of a single synapse. The biochemical network …
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Molecular Mechanisms Controlling Synaptic Vesicle Fusion
… But, in certain circumstances, such as in synaptic vesicles, spontaneous fusion is not desired, so a clamp protein is necessary to prevent this fusion until signaled to do otherwise. In synapses, this protein is called Complexin and a second protein, called Synaptotagmin, releases the clamp …
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Molecular Mechanisms Controlling Excitatory Synaptic Transmission
… neurotransmitter is released from the presynaptic cell and binds to postsynaptic receptors on another. In the case of excitatory synapses, the predominant neurotransmitter, L-glutamate, binds to postsynaptic AMPA receptors (AMPARs). Crucially, synaptic strength is plastic, and control of …
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EGFR signaling regulates synaptic connectivity via Gurken
… or epilepsy. To identify novel regulators of synaptic development, I screened for mutants with defects in synaptic morphology and growth at the Drosophila larval neuromuscular junction: NMJ). My screen identified several mutants with defects in various aspects of synaptic development. I …
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Differential Regulation of Synaptic Plasticity In Epilepsy
… comorbidities. Examining alterations in synaptic plasticity can give us insight into the epileptogenic phenotype as well as accompanying conditions like cognitive decline and psychosis that may be observed in subjects with TLE. We decided to investigate changes in long term potentiation …
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NOVEL DOPAMINERGIC SIGNALING MODULATING HIPPOCAMPAL SYNAPTIC TRANSMISSION
… of the VTA-dopamine system on hippocampal synaptic transmission are largely under-explored and the underlying mechanisms are unclear. The goal of this project was to investigate mechanisms involved in dopaminergic modulation of hippocampal neurophysiology. Specifically, I (1) examined if …
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Modulation of synaptic transmission by TRP channels
… is the site where sensory afferent fibers make synaptic connections with second order neurons. Somatic and craniofacial afferents terminate in spinal cord dorsal horn (SDH) and caudal spinal trigeminal nucleus (CSTN). Neurotransmitter release from first order nerve terminals regulates ascending …
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