Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 409 for “"Synapses"”.
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Microglial Phagocytosis of Bacteria and Synapses
… pathogens, microglial phagocytosis of synapses is a crucial facilitator of the ‘synaptic pruning’ that occurs in the developing brain, but this regulation is poorly understood. Here, the mechanisms that regulate microglial phagocytosis of synapses were studied. Calreticulin and …
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Epitaxial SiGe synapses for neuromorphic arrays
… associated with existing artificial synapses. Large variation arises in conventional devices due to the stochastic nature of metal movement through an amorphous synapse. Hence, passive arrays have only been demonstrated as small-scale systems. In this thesis, I developed …
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Neurologin Function in Excitatory and Inhibitory Synapses
Neuroligins (NLs) are postsynaptic cell adhesion molecules which by binding to presynaptic neurexins (NRXs) are thought to mediate synapse formation and function. Both NLs and NRXs are discussed in the genetic correlation to Autism. Over-expression of NLs could induce the formation of synaptic …
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Regulation of Molecular Composition at Glutamatergic Synapses
… for the formation of functional glutamatergic synapses. Here I examined the clustering of presynaptic (Brain-Specific L-Proline Transporter, PROT) and postsynaptic (N-Methyl-D-Aspartate Glutamate Receptor, NMDAR) molecular markers in rat hippocampal cultured neurons. PROT localized specifically …
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Regulation of Synaptic Vesicle Trafficking at Central Synapses
Synapses are where electrical information is converted to chemical signaling, allowing for careful regulation of inter-neuronal communication in the brain. At presynaptic terminals, synaptic vesicles fuse with plasma membrane in response to electrical stimulation, followed by rapid retrieval to the …
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Automated detection of ultrastructural features at neuronal synapses
… of vesicles in electron microscope images of synapses. We train a U-Net inspired model to perform pixel-wise segmentation of the vesicles against background pixels. We then use contour detection on the resulting segmentation maps to determine individual vesicle centers and effective diameters. …
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Synaptome mapping of glutamatergic synapses across the mouse brain
Synapses are specialised contacts between neurons. At postsynaptic terminals of glutamatergic synapses, protein complexes process and transmit the information received from the presynaptic terminal. Scaffolding proteins, among which members of the disc large homologue (DLG) family are the most …
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Cannabinoid regulation of excitatory synaptic transmission at hippocampal synapses
… transmission at different hippocampal CA1 synapses.<br/><br/>In this study, standard extracellular recordings were used to examine the effects of different selective CB1R agonists on excitatory synaptic transmission at the temporoammonic (TA) input to CA1 neurons and at the Schaffer …
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Expression and function of PSD-93 isoforms in hippocampal synapses
Die Informationsverarbeitung im Gehirn basiert darauf, dass sich die synaptischen Verbindungen zwischen den Nervenzellen in ihrer Stärke ständig anpassen können. Die Stärke der exzitatorischen Synapsen im Hippocampus hängt von der Anzahl der AMPA Rezeptoren (AMPARs) in der postsynaptischen …
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Super-resolution imaging of glutamate receptors trafficking at live synapses
… system. They communicate with each other via synapses. The synapse is the fundamental structure for signal transmission, which is composed of presynapse, postsynapse and a 20 nm synaptic cleft in between. Located on the tip of postsynapse is the postsynaptic density (PSD) that receives signals …
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Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
… Neurotransmitter Release from Retinal Ribbon Synapses Photoreceptors and bipolar cells in the retina form specialized chemical synapses called ribbon synapses. This type of synapse differs physiologically from “conventional” chemical synapses. While “conventional” synapses exocytose …
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Regulation of ageing by electrical synapses in the Nematode Caenorhabditis elegans
Electrical synapses formed by gap junctions are abundant in nervous systems and critical for brain function. They allow not only the exchange of ions, but also of metabolites and second messengers and have been implicated in the transmission of damage or death signals between cells. However, it was …
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Estrogenic modulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses
… at hippocampal Schaffer-collateral (SC)-CA1 synapses has been described in detail and at these synapses, estrogen can rapidly potentiate excitatory synaptic transmission (Oberlander and Woolley., 2017). The actions of estrogen at the anatomically distinct Temporoammonic (TA)-CA1 synapse is …
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The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)
… of GABA. RPeD1 has been shown to form reciprocal synapses with VD4 both in vivo and in vitro. When perfused with GABA (lmJ'i4), both cells hyperpolarised reversibly. The postsynaptic response could be due to the action of GABA presynaptically inhibiting RPeDI, or directly on postsynaptic GABA …
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Electrical synapses: cellular morphology and identification of connexins in the mouse retina
Das Ziel meiner Dissertation war die Zahl der deplatzierten Amakrinzelltypen (DAZ), die Identifikation der Cx45-exprimierenden Amakrinzellen (AZ) und Cx30.2-exprimierenden Ganglienzellen (GZ) zu erforschen. Außerdem wurde die Lokalisation von Cx57 in den Horizontalzellen (HZ) untersucht. Gefunden …
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Exploring a behavioral role for presynaptic inhibition at spinal sensory-motor synapses
… of sensory input establishes inhibitory synapses directly on the central terminals of sensory neurons. To date, however, the difficulty in gaining selective access to discrete classes of inhibitory interneurons within local microcircuits has left unresolved the contribution of presynaptic …
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Strength and dendritic organization of thalamocortical synapses onto excitatory layer 4 neurons
… of cortical activity, even though cortical synapses onto layer 4 (L4) neurons outnumber thalamic synapses ten to one. Previous in vitro studies have suggested that enhanced efficacy of thalamocortical (TC) relative to corticocortical (CC) synapses explains the effectiveness of the thalamus. …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
… structural dynamics of excitatory and inhibitory synapses in vivo, and their relation to each other, is not well understood. To gain insight into synaptic remodeling in the adult brain in vivo, we used dual- and triple- color two-photon imaging to track the dynamics of all inhibitory and …
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