Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Switch-II"”.
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Röntgenstrukturanalyse der GTPase-Domäne von Dynamin 1 und der Motordomäne von Myosin II
… norvegicus sowie der Motordomäne von Myosin II aus Dictyostelium discoideum in atomarem Detail aufgeklärt werden. Die vorgelegte Kristallstruktur der nukleotidfreien GTPase-Domäne von Dynamin 1 zeigt, daß die GTPase-Domäne in Säugerdynamin sehr ähnlich gefaltet ist wie in Dynamin A aus D. …
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Transition Networks : Computational Methods for the Comprehensive Analysis of Complex Rearrangements in Proteins
… Diese sind jeweils mit der Umordung der Switch I und Switch II Bereiche im Protein assoziiert. Basierend auf den Ergebnissen werden drei konkurrierende Mechanismen für den Übergang von Switch I identifiziert. In all diesen Mechanismen bewegt sich die Seitenkette von Tyr32 unterhalb des …
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Regulation of Guanine Nucelotide Exchange in Inhibitory G Protein Alpha Subunit by Activator of G Protein Signaling 3 and Novel Regulatory Peptides
… structure of Gai1 GDP:R6A complex shows that switch II region of Gai1, which is disordered in the GDP bound state, adopts an ordered structure through its direct interactions with R6A. Binding of R6A orients residues 202 to 204 of switch II (GG-loop) towards the nucleotide binding pocket and …
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Design and analysis of a scalable terabit multicast packet switch : architecture and scheduling algorithms
… demand for core network capacity. Existing switches/routers, due to the bottleneck from either switch architecture or arbitration complexity, can reach a capacity on the order of gigabits per second, but few of them are scalable to large capacity of terabits per second. In this dissertation, …
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Discovery of the First Endogenous Gain of Function Mutation in Drosophila RAS1 as a Dominant Suppressor of Apoptosis
… allele, rasR68Q, contains a mutation in the Switch II region of Ras and that it produces a GTPase protein with diminished enzymatic activity. RasR68Q is the first endogenous gain-of-function ras1 allele to be identified in Drosophila and represents one of very few hypermorphic Ras mutations …
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Structural Characterization of the Switch domain regions of Schistosoma mansoni druggable Adenylate cyclase-stimulating Gα-protein
… to praziquantel treatment, the two molecular switch domain regions (switch I and switch II) of S. mansoni has been identified as a promising druggable target against the parasite. The broad focus of this study was to explore the solubility, stability and druggability of the Gα protein from the …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… surface of the CNH domain and an α-helix in the switch II region of <i>Af</i>Rho1 may form the potential interaction surface. My work provides both genetic evidence and the molecular basis that the <i>A. fumigatus</i> Rom2 CNH domain regulates cell wall synthesis, therefore validate it as a …