Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Switch-I"”.
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Röntgenstrukturanalyse der GTPase-Domäne von Dynamin 1 und der Motordomäne von Myosin II
… Im Gegensatz zu anderen GTPasen ist das switch I-Threonin, das für die GTP-Koordination wichtig ist, in Dynamin 1 in seiner katalytisch aktiven Konformation gehalten. Desweiteren konnte anhand des Strukturmodells für Arg59 eine Funktion als Beschleuniger der GTP-Hydrolyse vorgeschlagen …
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Design and analysis of a scalable terabit multicast packet switch : architecture and scheduling algorithms
… demand for core network capacity. Existing switches/routers, due to the bottleneck from either switch architecture or arbitration complexity, can reach a capacity on the order of gigabits per second, but few of them are scalable to large capacity of terabits per second. In this dissertation, …
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Biophysical and computational insights into the stability of RhoB and its cancer-associated variants
… G proteins, that act as cellular signalling switches. RhoB is involved in regulating the cytoskeleton, angiogenesis, cell death, endosome trafficking and DNA damage repair. Unlike other small GTPases such as K-Ras, RhoA and Cdc42, RhoB is understudied in terms of its structure, dynamics, and …
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Single Molecule Förster Resonance Energy Transfer and Super Resolution Force Spectroscopy Study of Elongation Factor G Evolution, Conformation, and Function
… unknown. Cryo-EM studies indicated that the switch I region of EF-G undergoes major conformational changes following GTP hydrolysis, which may drive tRNA translocation. Multiple sequence alignment (MSA) of switch I identified a highly conserved threonine (Thr48) in prokaryotes, which may be …
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Transition Networks : Computational Methods for the Comprehensive Analysis of Complex Rearrangements in Proteins
… Diese sind jeweils mit der Umordung der Switch I und Switch II Bereiche im Protein assoziiert. Basierend auf den Ergebnissen werden drei konkurrierende Mechanismen für den Übergang von Switch I identifiziert. In all diesen Mechanismen bewegt sich die Seitenkette von Tyr32 unterhalb des …
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A sexually dimorphic circuit switch in higher olfactory centres
A sexually dimorphic circuit switch in higher olfactory centres In Drosophila the male sex pheromone cis-vaccenyl acetate (cVA) elicits different behaviours in males and females: while males are repelled by cVA, it stimulates female receptivity. However, olfactory receptor neurons and their …
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Global dynamics of Bordetella pertussis and implications for control
… genotypes and the impact of vaccine type switch. I developed an analytical framework that quantifies the relative fitness of different circulating genotypes through time. I found that the implementation of acellular vaccines was associated to large-scale changes in fitness and can explain …
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Theoretical Studies of Protein-Protein Interactions
… disruption of interactions between α-helix and switch I and loop L11 of kinesin.
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Biochemical and Biophysical Studies of Novel Features of Ras-related Protein Interactions
… among proteins as they act as molecular switches in the regulation of various biochemical reactions in the cell. They are regulated by protein-protein interactions targeted to the highly flexible switch regions. Mutations in G-proteins or their effectors may cause alterations in structure …
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Regulation of Guanine Nucelotide Exchange in Inhibitory G Protein Alpha Subunit by Activator of G Protein Signaling 3 and Novel Regulatory Peptides
… structure of Gai1 GDP:R6A complex shows that switch II region of Gai1, which is disordered in the GDP bound state, adopts an ordered structure through its direct interactions with R6A. Binding of R6A orients residues 202 to 204 of switch II (GG-loop) towards the nucleotide binding pocket and …
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Requirement and regulation of actin polymerization during endocytosis
… In this thesis I report the discovery of a switch that regulates the timing of actin polymerization during endocytosis. I characterize a novel component of the endocytic machinery, dip1p, which is involved in regulating this switch. I highlight additional modes of activation of actin …
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Investigating K-Ras inhibition by α-helical peptides
… revealing a novel binding pose between switch I and II of K-Ras(G12D). In addition to de novo screening, design of a K-Ras-binding α-helical peptide from RLIP76 RBD was attempted. RLIP76 RBD variants previously selected to bind K-Ras were validated biochemically, however their …
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Structural Characterization of the Switch domain regions of Schistosoma mansoni druggable Adenylate cyclase-stimulating Gα-protein
… to praziquantel treatment, the two molecular switch domain regions (switch I and switch II) of S. mansoni has been identified as a promising druggable target against the parasite. The broad focus of this study was to explore the solubility, stability and druggability of the Gα protein from the …