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Showing 1 to 13 of 13 for “"Suzuki-Miyaura reaction"”.
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Studies In the Optimization of the Suzuki-Miyaura Reaction
… have been made to optimize the Pd-catalyzed Suzuki-Miyaura reaction, but there is to date no generally useful protocol and forcing conditions are often required. One reaction variable that has often been neglected is the extent to which the supposed catalysts, bisphosphinepalladium(0) …
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Pre-transmetalation intermediates in the Suzuki-Miyaura reaction revealed: the missing link
The Suzuki-Miyaura reaction is currently the most practiced cross-coupling reaction due to its broad applicability, low toxicity of the metal (B), and the wide variety of commercially available boronic acid substrates. Despite the popularity of the Suzuki-Miyaura reaction, the precise manner in …
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Transmetalation from boronic esters to arylpalladium complexes without prior hydrolysis – mechanistic studies and preparative applications in the anhydrous, Suzuki-Miyaura cross-coupling reaction
… of transition-metal catalyzed, cross-coupling reactions has fundamentally changed the way chemists think about C–C bond formation. Within the class of transition-metal catalyzed, cross coupling reactions, the Suzuki-Miyaura reaction has emerged as the most popular method because of the relative …
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METAL-CATALYSED CROSS-COUPLING REACTIONS OF NITROGEN HETEROCYCLES
… imidazole and pyrrole. The products of these reactions then undergo palladium-catalysed C-C cross-couplings with aryl or heteroarylboronic acids under Suzuki-Miyaura conditions to provide a rapid entry to tris(hetero)aryl scaffolds comprising two or three N-heterocyclic rings. The sequential …
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Recent advances in palladium-catalyzed carbon-carbon and carbon-boron bond forming processes
… precatalysts and monophosphine ligands for the Suzuki-Miyaura cross-coupling reaction of heteroaryl boronic acids and esters has been developed. This method allows for the preparation of a wide variety of heterobiaryls in good to excellent yields and displays a high level of activity for the …
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Study of Bis-Imidazol-2-Ylidines as Ligands for Transition Metal Catalyzed Coupling Reactions
… was employed with the same results. A variety of reaction conditions and reagents were investigated including solvents, N-heterocyclic carbene species, palladium source, alkoxide base, palladium to ligand ratio and reaction time. Reactivity of the individual N-heterocyclic carbenes as ancillary …
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Development and investigation of novel chemoselective processes in Pd and Cu catalysis
… chemoselective processes across two cornerstone reactions in organic chemistry. Chapter one will describe the development of dual nucleophile/electrophile chemoselectivity in the Suzuki-Miyaura reaction. Chemoselectivity in this key crosscoupling reaction has previously only been achieved at …
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Controlling Site-Selectivity in Palladium-Catalysed Cross-Coupling Reactions using Non-Covalent Interactions Between Ligand and Substrate
Controlling selectivity in chemical reactions is a fundamental challenge in organic synthesis. This thesis explores controlling the site-selectivity of palladium-catalysed cross-coupling reactions by using a non-covalent interaction between a ligand and substrate. A library of phosphine ligands …
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I. Reaction mining—a next-generation platform for reaction discovery II. Rapid, anhydrous, homogenous Suzuki-Miyaura cross-coupling of aryl and alkylboronates
… areas of research and development on: (1) a reaction discovery platform enabled by the merger of high-throughput experimentation (HTE) and data science, and (2) preparative methods for aryl-aryl and B-alkyl Suzuki-Miyaura cross-coupling of boronic esters and boronates. Chapter 1 describes …
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Part I: synthesis and cross-coupling of the C1-C12 primary organoborane building block of amphotericin B; Part II: site- and stereoretentive cross-coupling of unactivated secondary boronic acids inspired by amphotericin B
… assembled using only a single cross-coupling reaction repeatedly. Such an iterative cross-coupling (ICC) strategy has been applied in our proposed total synthesis of clinically valuable polyene natural product amphotericin B (AmB). In our retrosynthetic analysis, AmB is disconnected into four …
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I. Development of three-component alkene carboamination reactions II. Palladium-catalyzed anti-Markovnikov oxidative amination of alkenes III. Chloroform as a carbon monoxide precursor: in or ex situ generation of co for pd-catalyzed carbonylations IV. Hydroalkylation of alkenes via photoredox catalysis
… progress in these critical fields is made, and reaction development lies at the core. In assessing compound classes found in the fields of medicinal chemistry and agrochemistry, it was recognized that nitrogen functionalities play an important role in imparting function to molecules. In a survey …
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Mechanistic studies on palladium-catalyzed coupling reactions
… individual steps of palladium-catalyzed coupling reactions. In one case, the oxidative addition of PhX (X = I, Br, Cl) to the complexes Pd(PtBu3)2 (1), Pd(1-AdPtBu2)2(2), Pd(CyPtBu2)2 (3), and Pd(PCy3)2 (4) (1-Ad = 1-adamantyl, Cy = cyclohexyl) was studied to determine the effect of steric …
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Dai polifenoli naturali agli analoghi sintetici bioattivi.
L’obesità è una patologia caratterizzata da un eccesso di grasso corporeo ed è associata ad un aumento del rischio di disturbi cronici e malattie cardiovascolari, cancro, osteoartrite e ipertensione. L’incidenza dell’obesità è spesso correlata a quella del diabete di tipo 2, una malattia …