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Showing 1 to 10 of 10 for “"Suzuki reaction"”.
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Modifications to the Suzuki reaction and mechanistic insights on the NBS mediated cleavage of benzylidene acetals /
… with modifying the carbon-carbon bond forming Suzuki reaction, which is utilized quite often as a means of combining molecular sub units in total synthesis applications. As previously stated the first area of the project was to develop high value chirons from D-glucose, but the mechanism of …
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Application of a palladium/tri-tert-butylphosphine catalyst system towards mild and general methods for carbon-carbon bond formation
… palladium-catalyzed carbon-carbon bond forming reactions utilizing the bulky and electron-rich trialkylphosphine, tri-tert-butylphosphine (P(t-Bu)3). We have concentrated on the utilization of aryl chlorides as substrates due to their lower cost and greater availability compared to traditionally …
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Computational study on the origins of asymmetric induction in Pd-catalyzed cross-coupling reactions and suggestions for improvements thereupon
The origins of asymmetric induction in the Suzuki-Miyaura cross coupling reaction are investigated computationally with density functional theory. Monophosphine-bound palladium complexes are analyzed in the context of oxidative addition to aryl halides, and ligands are explored in terms of steric …
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Synthetic and spectroscopic studies of 6-substituted chromone derivatives
… were also synthesized. The Suzuki cross-coupling reaction was also utilized, inserting a benzene ring in the chromone moiety of several chromone-2-carboxamides. The compounds synthesized were purified either by flash chromatography or recrystallization using ethanol-water. …
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Total synthesis of ulocladol A and analogues alternariol 0-methyl ether and alternariol
… elucidated.<br/>This report details the use of Suzuki coupling methodology to prepare ulocladol A and eighteen analogues. Several different catalyst systems are reported due to the steric and electronic effects of the substrates used in the Suzuki reaction; also included in the report are the …
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Towards the Design and Syntheses of Novel Triads Comprising Single Robson-Type Macrocyclic Dicopper(II) Cores Flanked by Two Terminal Polypyridyl Ruthenium(II) Complexes.
… complex was formed by the 2:2:2 condensation reaction of 4-bromo-2,6-diformylphenol and 1,3- diaminopropane with cupric chloride. Similarly, a new dibrominated dizinc(II) was synthesized from zinc tetrafluoroborate and the same diamine and dialdehyde. The new dicopper(II) complex did not …
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Synthesis of α, β-Substituted Alkenylphosphonates from α-Phosphonovinyl Triflates: I) Palladium Catalyzed Suzuki-Miyaura Cross-coupling with Aryl Boronic Acids II) Palladium Catalyzed Reduction
… substitutions and transition metal-mediated reactions. There is a growing interest in using α-phosphonovinyl pseudo-halides in transition metal-mediated cross-coupling reactions as a means to synthesize α, β-substituted alkenylphosphonates. Over the past three years, our group has developed a …
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1. Reinvestigation of a catalytic, enantioselective alkene dibromination and chlorohydroxylation, 2. Double cross-coupling reactions of siloxaborolates, 3. The enantioselective synthesis of 3-substituted morpholines using computer-guided catalyst design
… dibromination and chlorohydroxylation reactions from oft-cited literature studies are described. The reactions were performed with full fidelity to the original report wherever possible. Analysis of the enantiomeric composition was performed by CSP-HPLC or CSP-SFC, as opposed to the …
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Dearomative transformations in synthesis: I. Dearomative dihydroxylation with arenophiles II. Total synthesis of lycoricidine and narciclasine III. Towards the total synthesis of collybolide
Dearomatization reactions represent a powerful tool for the conversion of readily-available arenes into structurally complex, high-value intermediates in synthesis. Although there are many classic and modern approaches for overcoming the resonance stability inherent in these compounds, the …
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Supported catalysts, from polymers to gold nanoparticles supports
… advantage of being soluble under the catalytic reaction conditions but also, to be removable by changing the conditions of the surrounding media. Despite the great potential of these soluble supported catalysts, their use is very limited in today s synthesis. In addition, no set of rules have …