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Showing 1 to 20 of 26 for “"Suzuki cross-coupling"”.
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Development of Palladium(0)-Catalyzed Suzuki Cross-Coupling Polymerizations
… and reaction conditions, palladium(0)-catalyzed cross-coupling reactions would give us a good chance to achieve the goal. Thus, my Ph. D dissertation research projects focused on developing Pd(0)-catalyzed Suzuki cross-coupling polymerization reactions including controlled ones.</p> <p>My …
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Synthesis Of 2-Boron Substituted-1,3-Dienes And Their Diels-Alder/Suzuki Cross Coupling Reactions
Dissertation under the direction of Mark E. Welker, Ph.D., Professor of Department of Chemistry, Wake Forest University
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A Stereospecific Pd-Catalyzed Suzuki Cross-Coupling Reaction and a Statistical Study of the Ligand's Role in Stereoselection
… development of palladium-catalyzed carbon-carbon cross-coupling reactions has profoundly influenced the manner through which we approach the synthesis of complex organic molecules. Among established cross-coupling reactions, which include Kumada, Negishi, and Stille reactions, the Suzuki …
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Synthesis and Characterization of Model Compounds For Self-Assembled Dithienophosphole-Based Phosphamides
… core, the emitter compounds were synthesized via Suzuki cross-coupling reactions. The model compounds, incorporating hydrogen-bonding moieties, were prepared through substitution at the phosphorus center. Comprehensive characterization was performed, including optical and spectroscopic analyses, …
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Nickel-catalyzed cross-couplings of unactivated secondary and tertiary alkyl halides and photoinduced copper-mediated asymmetric C-N cross-couplings
… the development of two nickel-catalyzed Suzuki cross-coupling methodologies that employ alkyl halides as electrophiles. In Section 1.1, asymmetric [gamma]-alkylation relative to a carbonyl group is achieved via the stereoconvergent cross-coupling of racemic secondary [gamma]-chloroamides …
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Total Synthesis of Marine Macrolide Mangrolide D
… and interchangeable bond forming reactions: Suzuki cross coupling, ring closing metathesis and α-selective glycosylation reaction. The convergent assembly of chemical building blocks enabled the quick access to mangrolide D and served as a potential pathway to other glycosylated macrolide …
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Synthetic and spectroscopic studies of 6-substituted chromone derivatives
… were also synthesized. The Suzuki cross-coupling reaction was also utilized, inserting a benzene ring in the chromone moiety of several chromone-2-carboxamides. The compounds synthesized were purified either by flash chromatography or recrystallization using ethanol-water. …
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Synthesis and biological evaluation of functionalized benzoxaboroles as potential antimicrobial agents
… medicinal, and materials chemistry, and also as cross-coupling agents in synthetic chemistry. Boronic acids often function as inhibitors for various enzymes due to their unique electronic and physicochemical properties. B-hydroxy-1,2-oxaborolanes (benzoboroxoles) are a class of cyclic boronic …
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The use of chiral auxiliaries in the synthesis of chemically and biologically important chiral compunds
… reaction to construct the Evans syn-adduct, a Suzuki cross-coupling for the (E,Z)-diene construction, and an intramolecular Horner-Wadsworth-Emmons olefination for construction of the E-enone of the macrolide.
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Development of New Synthetic Methods for Transition Metal-Catalyzed Organic Reactions and Synthesis of Curcumin-Based Adducts
… carbon-carbon bond-forming reactions, such as Suzuki coupling reactions and addition reactions, are among the most powerful and versatile transformations in organic synthesis. My work is centered on integrating these highly efficient reactions in a sequential or tandem fashion and aims to …
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Novel titanium carbenoid reagents: diversity orientated synthesis of indoles and spirocycles
… boronate functionality in enol ethers, Suzuki cross-coupling reactions were performed with 12 aryl iodides to give a 96-member library after cleavage from resin with mild acid. 79 members of the library were confirmed to be 2,5-disubstituted indoles. Also reported is the use of tertiary …
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IMPROVING THE SCOPE AND UNDERSTANDING OF THE SYMMETRIC AND ASYMMETRIC SUZUKI COUPLING REACTION
Investigations into the Symmetric and Asymmetric Suzuki cross-coupling reaction have been described. A new reaction protocol has been developed in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and …
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Synthesis of contorted nanographenes via multi-fold alkyne benzannulation reactions
… core to get a variety of π-extended HBC NGs. The Suzuki cross-coupling of the halogen(s) substituted smaller polycyclic aromatic hydrocarbons with diyne boronic ester gave polyalkyne precursors, which were subjected to multi-fold alkyne benzannulation reaction to af-ford larger, highly soluble …
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Graphene-Supported Metal Nanoparticles For Applications in Heterogeneous Catalysis
… materials were successfully used to investigate Suzuki cross-coupling reaction as an important reaction in the field of pharmaceutical applications. In this research, nanostructured materials were used as solid support catalysts which showed remarkable improvements in the aspects of size, surface …
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Design and stereoselective synthesis of novel bicyclicbeta-turn dipeptide mimetics and cis-4-substitutedproline analogues for peptides and peptidomimetics
… of dehydroamino acid intermediates followed by Suzuki cross-coupling.
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The Modified Stereospecific Stille Reaction: Palladium-Catalyzed Cross-Coupling Reactions Involving Secondary and Tertiary Alkyl Carbastannatranes
… introduction of transition metal-catalyzed cross-coupling reactions is given. While the formation of C(sp<sup>2</sup>)–C(sp<sup>2</sup>) bonds has been studied extensively, C(sp<sup>3</sup>)-C(sp<sup>2</sup>) bond formation still presents a challenge due to competitive β-hydride elimination …
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The versatility and utilization of phosphorus based compounds in classic carbon-carbon bond forming and esterification reactions
… reusable media for the palladium catalyzed Suzuki cross-coupling reaction of aryl halides, including aryl chlorides, under mild conditions. The cross-coupling reactions were found to proceed in THPC containing small amounts ofwater and toluene (single phase) using potassium phosphate and 1% …
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Modifications to the Suzuki reaction and mechanistic insights on the NBS mediated cleavage of benzylidene acetals /
… with modifying the carbon-carbon bond forming Suzuki reaction, which is utilized quite often as a means of combining molecular sub units in total synthesis applications. As previously stated the first area of the project was to develop high value chirons from D-glucose, but the mechanism of …
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New Carbazole Based Materials for Optoelectronic Applications
… to the core molecule as side arms via a trifold Suzuki cross coupling reaction. The target compounds were highly purified by medium pressure liquid chromatography (MPLC) as purity is an important prerequisite for organic materials to be used for optoelectronic applications. Before the new …
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