Global ETD Search
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Showing 1 to 5 of 5 for “"Suzuki coupling reaction"”.
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IMPROVING THE SCOPE AND UNDERSTANDING OF THE SYMMETRIC AND ASYMMETRIC SUZUKI COUPLING REACTION
Investigations into the Symmetric and Asymmetric Suzuki cross-coupling reaction have been described. A new reaction protocol has been developed in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and …
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Development of Novel Nicotinic Receptor Mediated Therapeutic Agents: Synthesis and Biological Evaluation of Novel Epibatidine Analogs and the First Total Synthesis of Anabasamine and Related Analogs
… was formed via a [4+2] Diels-Alder cyclization reaction between the acetamidoacrylate and Danishefsky's diene. These 1- (pyridyloxymethyl)-7-azabicyclo[2.2.1]heptane ring systems were then tested in vitro as potential á4â2 nicotinic acetylcholine receptor ligands with high potency and …
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Studies Towards the Total Synthesis of Patellazole B
… union and formation of the macrocycle. A Heck coupling reaction has been employed to construct the C19-C20 bond and a Suzuki coupling reaction has been developed to facilitate the C12-C13 bond formation. These two cross couplings have delivered the C1 - C25 fragment, 360, the final compound …
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Novel small molecules for modulation of bacterial signaling pathways
… by applying EDC, DCC or EDC/HOBt mediated amide coupling methods. On docking study, the indole-based AHL mimics showed strong binding affinity with P. aeruginosa LasR receptor, with compound 146d having highest docking scores of 61.58. The reactions of brominated furanones with hydrazines have …
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Further Exploring the Structure Activity Relationship (SAR) of MMV008138 and MMV1803522
The war between human and malaria has never stopped, and the development and application of antimalarial drugs has not eradicated this terrible disease. To fight drug-resistant malaria, many leads have been studied over the years. (1S,3R)-MMV008138 and MMV1803522 are two compounds that have been …