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Showing 1 to 20 of 35 for “"Suzuki Coupling"”.
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IMPROVING THE SCOPE AND UNDERSTANDING OF THE SYMMETRIC AND ASYMMETRIC SUZUKI COUPLING REACTION
Investigations into the Symmetric and Asymmetric Suzuki cross-coupling reaction have been described. A new reaction protocol has been developed in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and …
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The synthesis and applications of a biaryl-based asymmetric phosphine ligand
… of the chiral phosphine ligand to the asymmetric Suzuki-Miyaura cross-coupling reaction was also investigated. This phosphine ligand has yielded promising results in the asymmetric Suzuki-coupling of hindered boronic acids with the electron-rich aryl bromide, 1-bromo-2- methoxynaphthalene, to …
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Substituované oligothiofeny pro přípravu supramolekulárních struktur
… bromace, borylace a v neposlední řadě Suzuki coupling. Dále se předkládaná práce zabývá tématikou komplexace syntetizovaného oligomeru se zinečnatými kationty, zahrnuty jsou také UV-VIS spektra a emisní spektra fluorescence titrační řady.
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Late transition metal catalyzed C-N and C-C bond forming reactions
… exceptionally effective in the C-N, C-0, and C-C coupling procedures. For some substrate combinations, these palladium catalysts are effective for the room-temperature catalytic amination of aryl chlorides. These palladium catalysts are also highly effective for Suzuki coupling reactions of aryl …
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Controlling Site-Selectivity in Palladium-Catalysed Cross-Coupling Reactions using Non-Covalent Interactions Between Ligand and Substrate
… site-selectivity of palladium-catalysed cross-coupling reactions by using a non-covalent interaction between a ligand and substrate. A library of phosphine ligands were synthesised that incorporate an anionic or hydrogen bond acceptor group. They were first evaluated in the Mizoroki-Heck …
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Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling
… on the synthesis of pinane thromboxane A₂ via a Suzuki-Miyaura coupling. Advantages of this route include the first example of the use of the Suzuki coupling with this compound, fewer steps within the synthesis and the use of less-toxic chemicals. Accomplishing the Suzuki-Miyaura coupling has …
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Total synthesis of lycoricidine via photochemical dearomative dihydroxylation
… nucleophile for an unprecedented transpositive Suzuki coupling. Hetero-Diels-Alder cycloaddition is used to form the syn-1,4-amidoalcohol functionality. This new route completes the total synthesis of lycoricidine in eight steps, shorter than any previously completed synthesis.
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POLYMER ORGANIC SEMICONDUCTORS AND THEIR DEVICES
… devices. Firstly, synthetic methodology based on Suzuki coupling for generation of high molecular weight polymers is discussed using well-known fluorene-containing-polymers. Next, different molecular weight high-performance diketopyrrolopyrrole-based co-polymer was synthesized; their field-effect …
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Synthesis and Optical Properties of Four Oligothiophene-Ruthenium Complexes and Synthesis of a Bidentate Ligand for C-F Bond Activation
… compounds were synthesized through Stille and Suzuki coupling of commercial reagents. Ligands were then bound to tungsten to form the tetracarbonyl complexes.
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… via reductive amination and Buchwald-Hartwig coupling reactions, giving four new examples of porphyrin-cyclen conjugates.A Suzuki coupling methodology has been used to synthesise a porphyrin-cyclen conjugate with an aryl-aryl linkage which exhibits enhanced stability towards acidic …
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Total synthesis of ulocladol A and analogues alternariol 0-methyl ether and alternariol
… elucidated.<br/>This report details the use of Suzuki coupling methodology to prepare ulocladol A and eighteen analogues. Several different catalyst systems are reported due to the steric and electronic effects of the substrates used in the Suzuki reaction; also included in the report are the …
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Low-temperature protonation studies of an electron-poor osmium methyl complex, and molecular precursors for the construction of graphene nanostructues with atomically precise edge structures
… a binomial quintet in the 13C NMR with a coupling constant (127 Hz) almost identical to that of free methane (125 Hz). Kinetic analysis revealed that the enthalpy and entropy of activation for methane loss was ΔH‡ = 14.9 ± 1.5 kcal mol-1 and ΔS‡ = 12.3 ± 8.8 cal mol-1 K-1, respectively, …
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Synthesis and application of sterically flexible and water-soluble phosphine ligands in palladium catalysis
… on catalyst activity, particularly for the Suzuki coupling of sterically hindered substrates. I have also synthesized two new water-soluble phosphine ligands that utilize two sterically hindered, electron-rich alkyl groups (di-tert-butyl or di-1-adamantyl) in conjunction with a flexible …
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Calixarene Linked Bis-Porphyrin Hosts for Fullerenes and the Assembly of Supramolecular Ferrocene-Porphyrin-Fullerene Triads
… different substituents at the meso-positions. Suzuki coupling has been employed with various boronic acids to form A2BC substituted porphyrins with aminophenyl at the 5-position, 3,5 ditert- butyl phenyls at the 10 and 20-positions and various substituents at the 15-position. These porphyrins …
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A dynamic knowledge graph approach to self-driving chemical laboratories
… graph approach is also applied to optimise two Suzuki coupling reactions for efficient synthesis of challenging molecules, obtaining 82 mg of the final product from a 40 mL scale-up that would be otherwise difficult to access without extensive process redesign and manual synthesis efforts.
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Development of Novel Nicotinic Receptor Mediated Therapeutic Agents: Synthesis and Biological Evaluation of Novel Epibatidine Analogs and the First Total Synthesis of Anabasamine and Related Analogs
… provided the piperidine ring moiety and a Suzuki coupling reaction introduced the bipyridyl moiety to anabasamine in five steps and 23% overall yield. In addition, this methodology was applied successfully to the synthesis of nicotine and other related analogs. In particular the synthesis …
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The search for small molecule inhibitors of histone acetylation
… details the synthesis of<br/>anacardic acid by Suzuki coupling and the application of the Mitsunobu synthesis to generate a<br/>series of anacardic acid analogues. In vitro biological assays were used to assess the potency of<br/>anacardic acid and forty four analogues towards cancer cell growth …
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Synthesis, Characterization, and Evaluation of Novel BODIPY Dyes With Theranostic Applications
… The use of highly efficient palladium-catalyzed Suzuki coupling yielded two carboranyl-BODIPYs of varying optical properties in good yield. The photophysical properties and blood brain permeability of these novel-carboranyl BODIPYs was reported.
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Synthesis, multiscale-multiphase characterization and applications of thiophene-based biohybrids
… oligomers. Our innovative heterogeneous Suzuki coupling methodology, carried out in EtOH/water or isopropanol under microwave irradiation, allowed us to obtain alkyl substituted oligothiophenes and thiophene based co-oligomers in high yields and very short reaction times, free from …
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Studies into the Biosynthesis and Chemical Synthesis of Indolocarbazoles and Related Heterocyclic Compounds. Metalation of Indole-6-Carboxamide.
… heterocyclic analogues of lycogarubin C. Suzuki coupling of appropriately functionalized 3,4-dibromopyrrole or 3,4-bis(trifluoromethanesulfonyl)pyrrole was effective for numerous π-excessive five-membered heterocyclic-3-boronic acids. The optimized conditions were less effective for …
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