Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Sustained Drug Delivery"”.
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Development of biodegradable implants for sustained drug delivery
The advent of sustained drug delivery has resulted in many patient benefits including reduced frequency of drug administration and reduced side effects. Implantable drug delivery benefits from these advantages, but importantly, can be removed if adverse effects necessitate it. In this thesis, …
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Controlled Release System for Localized and Sustained Drug Delivery Applications
… such as excess of initial burst release, low drug efficiency, non-degradability of the system and low reproducibility. The present project aims to offer an alternative by developing a technique to prepare uniform, biodegradable particles (~19 µm) that can sustainably release a drug for a …
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Ocular Iontophoresis of Nanocarriers for Sustained Drug Delivery to the Eye
… as a viable modality to deliver therapeutic drugs for the treatment of eye diseases. Although several studies have been conducted to examine the utility of iontophoresis for both charged and neutral molecules, the understanding of the mechanisms controlling the iontophoretic delivery of …
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A Novel IN SITU Gel for Sustained Drug Delivery and Targeting
… have also been used as matrix material for sustained drug delivery of both hydrophilic and hydrophobic drugs. GMO forms liquid crystalline cubic phases in excess of water. This unique property of GMO is responsible for its bioadhesive property along with its ability to serve as a sustained …
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Biodegradable dextran and PEG micro- and nanogels: physicochemical properties and sustained drug delivery features
De laatste jaren is de ontwikkeling van macromoleculaire geneesmiddelen in de strijd tegen erfelijke ziekten, kanker of hart- en vaatziekten enorm toegenomen. Het potentieel van deze peptiden, eiwitten of (oligo)nucleotiden zou haast oneindig zijn, ware het niet dat er zich nog verschillende …
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Biodegradable in situ forming photocrosslinked implants for sustained protein delivery to the posterior segment of the eye
Drug delivery to the posterior segment of the eye is a significant challenge, particularly in the context of sustained drug delivery for the treatment of chronic ocular conditions. The challenge is further increased due to the fact that the anti-VEGF agents, used to treat two of the most pertinent …
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Injectable in situ Gelling Metronidazole System for Treating Jawbone Infections
… there is a need for developing a metronidazole delivery system capable of releasing the drug at the site of jawbone infections at a sustained rate over a period of one week. Hence, this study addresses the development and characterization of an in situ gel forming formulation loaded with …
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Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration
… territory for the development of novel drug delivery systems. New methods for drug delivery are being investigated exploring the use of nanoparticles and other polymeric materials. The goal of this project is to study the potential use of poly(lactide-co-glycolic acid)-polyethylene …
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Charge-based transport and drug delivery into cartilage for localized treatment of degenerative joint diseases
… and therapeutics to tissue chondrocytes. No OA drug has yet passed the safety criteria of clinical trials due to ineffective intra-articular (i.a.) delivery methods, which require very high drug doses that cause systemic toxicity. There is a need to design local delivery mechanisms that can …
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Development of versatile drug delivery strategies using PLGA nanoparticles
Nanoparticle-mediated drug delivery is a promising approach for the delivery of various drug types to the site of disease in an effort to improve efficacy. Development of polymeric nanoparticles (NP) with slow drug-release kinetics coated with targeting ligands enables cell-specific sustained drug …
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Incorporation and release of macromolecules from biodegradable polymer vehicles
… for the generation of microparticulate sustained drug delivery devices. In order to overcome this low encapsulation efficiency, a W/0 single emulsion technique was developed and evaluated in an attempt to minimise the loss of the macromolecule into the continuous aqueous phase and …
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Immunospecific albumin microspheres as a drug delivery system for cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma
… to the malignant cells. This mode of targeted delivery allows for efficient tumour cell kill whilst sparing surrounding normal tissue and substantially reducing side-effects. This project examined the possible therapeutic role of a targetable sustained drug delivery system, albumin …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… the aim to improve the Triiodothyronine (T3) delivery to hepatic cancer cells and nanosuspensions were proposed to enhance dermal bioavailability of Diclofenac acid, a potent nonsteroidal anti-inflammatory drug (NSAID) with a very low aqueous solubility. T3, is a thyroid hormone normally …
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Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
… have been successfully synthesized for long term delivery in the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA approved biodegradable polymer such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB …