Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"Susceptibility testing"”.
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A multiplexed microfluidic platform for antibiotic susceptibility testing
Antibiotic susceptibility testing represents a key first step for determining therapeutic regimens to treat bacterial infections. Current technologies are slow and cumbersome, require large sample volumes for analysis, have poor detection sensitivity and limited combinatorial capabilities. These …
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Comparison of Micrscan Identification and Susceptibility Testing Methods for Streptococcus Dysgalactiae to Conventional Biochemical Reactions and Kirby-Bauer Susceptibility Testing Methods
… similar to S. dysgalact iae. The antimicrobial susceptibility of 94 S. dysgalactiae isolates to 16 antibiotics was determined by the MicroScan system. Of the antibiotics tested, each demonstrated greater than 85% susceptibility against the 94 strains of S. dysgalactiae. Of the 16 antibiotics …
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Susceptibility Testing of Pathogenic Fungi With a Radiometric System
A radiomethric method was used to determine the susceptibility of clinical isolates of dimorphic fungi (Histoplasma capsulatum, Blastomyces dermatitidis, Sporothrix schenckii) to selected antifungal agents. Antifungal agents evaluated were Amphotericin B, 5-fluorocytosine, Nystatin, Ketoconazole, …
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Single-cell mass measurements for drug susceptibility testing in cancer
Measuring the size distributions of micron-scale particles is of central importance in the biological sciences and for a wide range of industrial processes. The suspended microchannel resonator (SMR) is a sensor that measures the mass of individual micron-scale particles by detecting a shift in …
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Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
… Africa, little is known about the antifungal susceptibility of local yeast isolates. The aim of this study was therefore to determine the antifungal susceptibility profile of local Candida species and Cryptococcus neoformans isolates and the molecular mechanisms of resistance to different …
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Outpatient Antibiotic Prescribing, Dispensing and Susceptibility Testing in a Primary Care Spinal Cord Injury Cohort
… patterns; 2) determine patterns of urine culture susceptibility testing for UTI indicated antibiotic prescriptions; and 3) identify who prescribes outpatient antibiotics. This was a retrospective cohort study using linked electronic medical records and health administrative databases from Ontario. …
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A Novel High Throughput Platform for Assessing Bacterial Growth and Morphology Enables Rapid Antibiotic Susceptibility Testing
… and calls for tools that enable rapid antibiotic susceptibility testing (AST). This thesis introduces the Multipad Agarose Plate (MAP): an innovative platform that can perform rapid AST in under three hours. The platform comprises 96 agarose pads and relies on single-cell timelapse microscopy to …
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Developing a microfluidic-microwave platform for real-time, non-invasive and sensitive monitoring of pathogens and antibiotic susceptibility testing
… of service is infection diagnosis and antibiotic susceptibility testing. Due to issues with infection diagnosis and outdated antibiotic susceptibility testing (AST) methods, physicians are over-prescribing broad-spectrum antibiotics. This coupled with patients’ non-compliance in antibiotic …
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Elucidation of the Molecular Mechanisms That Contribute to Variation in Susceptibility Testing Show the Need for Alternative Detection Methods of KPC-producing Gram-negative Bacteria
… KPC-producing organisms pose. Although in vitro testing indicates that the KPC β-lactamase can efficiently hydrolyze the carbapenems, multiple studies have reported variability in susceptibility testing of KPC-producing clinical isolates. The first hypothesis tested in this dissertation was that …
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Acinetobacter baumannii : an evaluation of five susceptibility test methods to detect tobramycin resistance in an epidemiologically related cluster
… only therapeutic options. The Vitek2 automated susceptibility testing (AST) is used in the clinical laboratory to determine selected susceptibility profiles. The suspicion of a possible AST-related technical error when testing for susceptibility to tobramycin in A. baumannii precipitated this …
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Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
… the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which these …
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The biochemical and antibiogram characteristics of aerobic gram negative enteric bacilli, with special reference to Escherichia coli, from macaws
… the biochemical activity and antimicrobial susceptibility patterns (antibiograms) of 104 gram-negative bacteria, represented by six species of bacilli, isolated from ten macaws of the genus Ara. Bacterial samples were acquired from fecal matter of six different species of macaws, ages one to …
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Development of Antioxidant Treatments for Asphalt Binders and Mixtures
… tensile strength, fracture energy, and moisture susceptibility testing. The results of the study indicate that asphalt aging could be reduced significantly through the use of antioxidant treatments developed during the research.
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Molecular Characterisation Of Clostridium Perfringens Isolates From Patients At Groote Schuur Hospital
… infections, as only identification and drug susceptibility testing are done in routine laboratories. The main aim of this study was to characterise 19 clinical isolates of C. perfringens (collected between 2017- 2020) using phenotypical and molecular methods such as PCR-based toxin typing, …
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Investigation of the Genetic Basis of Antibiotic Resistance in Mycobacterium tuberculosis
… the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which these …
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CRISPR-integrated Biosensors for Human Health: Novel strategies for pathogen detection and cancer screening
… bacteriophage was used for rapid antimicrobial susceptibility testing in Escherichia coli (E. coli). Second, a CRISPR/Cas12a-based electrochemical sensor was designed for the detection of Salmonella Typhimurium in food samples. Third, a CRISPR/Cas14a system combined with blocker displacement …
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Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections
… and flow cytometry) and killing efficacy (with susceptibility testing) of AMB-IONP in fungal clinical isolates of Candida species were evaluated and compared with standard drug AMB deoxycholate (AMB-D) data. Third, the cellular uptake mechanisms with endocytosis inhibitors and intracellular …
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Assessment of antibiotic resistance phenotypic patern in some commensal bacteria isolated from meat and dairy products
… and dairy products using phenotypic antibiotic susceptibility tests. Antibiotic susceptibility testing was performed by disk diffusion method on Mueller-Hinton agar according to the Clinical Laboratory Standards Institute (2007) standards. A total of twenty eight (28) antibiotics were used to …
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Technological advancements towards paper-based biomolecular diagnostics
… of a paper-based diagnostic for antibiotic susceptibility testing.
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Similaridade genotípica de Salmonella enterica isolada de animais silvestres e exóticos em cativeiro em Ohio, EUA
… the isolates were subjected to antimicrobial Susceptibility testing by disk diffusion method, serotyping and genotyping by macrorestriction of chromosomal DNA. Salmonella was detected in 56/225 (25%) of fecal samples, 6/56 (11%) of environmental samples and 6/38 (16%) of food samples. This …
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