Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Survivin"”.
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Effects of survivin and survivin inhibition in canine models of lymphoma and osteosarcoma
… need of more effective therapeutic approaches. Survivin, an IAP (inhibitor of apoptosis) family member protein that inhibits apoptosis and drives cell proliferation, is commonly elevated in human and canine cancer. Survivin expression is a negative prognostic factor in both dogs and humans with …
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Modulation of T Lymphocytes by Tumor-Released Survivin
… a role for the Inhibitor of Apoptosis protein Survivin as a secreted protein in the extracellular milieu, where it is capable of entering malignant cells and inducing a more aggressive phenotype. We hypothesized that tumor-secreted Survivin could be responsible for modulation of T lymphocytes …
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Exosomal Survivin-T34A: A Novel, Potential Cancer Therapeutic
… using Gemcitabine could improve survival rates. Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is expressed in virtually all cancer cells, but not detectable in most normal cells outside of development. Mutation of Survivin’s Thre-onine 34 to Alanine (Survivin-T34A) …
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Survivin: Regulation by YY1 and Role in Pancreatic Cancer Combination Therapy
… people of all ages, races, and background. Survivin, the fourth most common transcript found in cancer cells, is a protein that is thought to be involved in the enhanced proliferation, survival, and metastasis of cancer cells. Therefore understanding how this gene is regulated is potentially …
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Regulation of Survivin Gene Expression In The Human Endometrium and Endometrial Cancer
… of EC progression is the cell survival protein survivin.
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Discovery of Novel Tubulin Polymerization Inhibitors and Survivin Inhibitors as Potential Anticancer Agents
… two important cancer targets: tubulin and survivin. Microtubules play important role in mitosis and cell division. Cancer cells divide more rapidly than normal cells, and thus are more sensitive to tubulin targeting agents which disrupt mitosis. Targeting tubulin for anticancer treatment …
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Expression of Survivin : Possible Predictor of Local Recurrence after Curative Resection for Rectal Cancer
… response within same clinicopathologic stage. Survivin, a novel member of IAP protein, is often associated with increasing recurrence risk and poor prognosis. We investigated the expression of survivin in rectal cancer and its potential impact on local recurrence. Retrospective …
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THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN INCREASES P34CDC2 PHOSPHORYLATION AND ENHANCES CELL SURVIVAL AND PROLIFERATION BY PROTECTING THE WEE1 KINASE FROM DEGRADATION BY CASPASE-3
The anti-apoptotic protein Survivin and the cyclin-dependent kinase p34Cdc2 are involved in cell cycle progression and apoptosis. Activation of Cdc2 is required for its pro-apoptotic activity, which can be inhibited by phosphorylation at Tyrosine-15 (Tyr15). In transduced IL-3-dependent murine BaF3 …
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Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors
… we explored for anticancer intervention was survivin. Survivin is the smallest member the inhibitor of apoptosis protein family and its overexpression in tumor cells is been positively correlated with the development of multidrug resistance and radiation resistance. Because it is …
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Discovery of Novel Tubulin Inhibitors and Selective Survivin Inhibitors for Advanced Melanoma and Total Synthesis of Bioactive 20S-hydroxyvitamin D3
… binding site and selective small-molecule survivin inhibitors for treating advanced melanoma. Extensive structure-activity relationship (SAR) studies of lead molecules ABI-231 and UC-112 have been performed.</p> <p>Chapter 1 will introduce the current situation of advanced or metastatic …
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Overcoming Acquired Resistance to BRAF Inhibitors by Novel Synergistic Drug Combination and Discovery of Novel Smac Mimetics as Selective Survivin Inhibitors
… on the discovery of a series of small molecule survivin inhibitors. Inhibitors of apoptosis (IAP) proteins are widely considered as promising cancer drug targets, especially for drug-resistant tumors. Mimicking the IAP-binding motif of second mitochondria-derived activator of caspases (Smac) is …
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Vitrification of Bovine Oocytes
… gene expression (Fas-FasL, Bax, Bcl-2, and survivin) in conjunction with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase assays. Mouse zygotes were exposed to increasing concentrations of ethylene glycol (EG), Ficoll-70 and sucrose in phosphate buffered …
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NEW INSIGHTS INTO PATHOGENESIS AND PROGNOSIS OF CANINE SARCOMAS
… evaluating the immunohistochemical expression of survivin and β-catenin in a series of retrospectively collected surgically excised cPWT samples to investigate their possible involvement in the tumorigenesis and progression of these tumors. Additionally, the study attempted to recognize the …
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Effects of iloprost on embryo development in vitro
… that the mechanism involves the induction of the survivin pathway. In this study, growth patterns of mouse embryos in four different groups were examined: an Iloprost group, a YM-155 (which induces apoptosis) group, a combination of YM-155 and Iloprost group, and a control group which was cultured …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… by targeting three important cancer targets: survivin, MDM2, and tubulin. Survivin, a member of the inhibitor of apoptosis proteins (IAPs) family, serves as both an apoptosis suppressor and a pivotal player in cell division. Its significance as a cancer drug target arises from its heightened …
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An Assessment of Universal Tumour Associated Antigens in Primary Liver Neoplasms
… a digital pathology platform. Telomerase and Survivin, the two targets of these endeavours, have previously been shown to be expressed in numerous cancer types, earning the title ‘universal tumour associated antigen.’ The techniques used in this research project are, mostly, already used in …
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Engineering and characterizing human T cell receptors for cancer immunotherapies
… of a TCR for high-affinity against the survivin/HLA-A2 complex. Survivin is an anti-apoptotic protein overexpressed in a variety of cancers. A TCR isolated from peripheral lymphocytes was stabilized as a single-chain TCR (consisting of variable domains linked by a flexible linker) on the …
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Cellular Coping Mechanisms to Hypoxia in the Longhorn Sculpin (Myoxocephalus octodecemspinosus) Brain
… using RT-QPCR, and HIF-1α, active caspase 3, and survivin, were explored at the protein level using immunohistochemistry and fluorescence microscopy. HIF-2α mRNA levels decreased significantly after hypoxic exposure, compared to normoxic levels, while Hsp70 levels remained unchanged. Using …
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Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds
… studied by quantifying Bcl-2, Bax, Caspase-3, Survivin, EGFR, and VEGF genes expression using RT-PCR. CD spectroscopy analyzed the nsLTP1 conformational changes after thermal treatment for structure stability determination. The RP-HPLC was used to analyze the nsLTP1 degradation rate in human …
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Vergleich der Genexpression im entzündlichen Kolonepithel und im kolorektalen Karzinom im Hinblick auf das erhöhte Tumorrisiko bei chronisch entzündlichen Darmerkrankungen
… noch vor Entstehen der Dysplasie anzeigen soll. Survivin bestätigt sich auch im Kolonepithel als Tumormarker sowohl auf RNA- wie auch auf Proteinebene. Ob die erhöhte Survivin-RNA-Expression in einigen Proben der CU-Gruppe im Sinne eines damit verbundenen Tumorrisikos interpretiert werden kann, …
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