Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Survival studies"”.
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Aspects of Hylotrupes bajulus (L.) biology in Virginia (Coleoptera: Cerambycidae)
… different than European beetles; 2) Outdoor survival studies of the larvae indicate that H. bajulus can live under natural conditions in Virginia's varied climatic regions. Over the course of two years 27 adults have been collected in such field conditions as fence posts, outhouses, screen …
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Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria
… from many foreign stress factors and secures its survival. Studies have shown the mycothiol-deficient bacteria are hypersensitive to external stresses and hence inhibition of the biosynthesis of mycothiol could be a drug lead against TB.
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Cure Rate Models with Nonparametric Form of Covariate Effects
… for cure rate data. Such data can be found in survival studies with long term survivors. Consequently, the population consists of the susceptible and non-susceptible sub-populations with the latter termed as "cured". The modeling of both the cure probability and the hazard function of the …
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Response Adaptive Design using Auxiliary and Primary Outcomes
… observed. This presents difficulties for survival studies, which may require long durations to observe the primary endpoint. Therefore, we introduce auxiliary endpoints to assist the adaptation with the primary endpoint, where an auxiliary endpoint is generally defined as any measurement …
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Oxygen toxicity in Campylobacter jejuni: physiological comparison of a microaerophilic wild-type strain with an aerotolerant mutant
… times when cells were cultured under 21% oxygen. Survival studies revealed that MC711-01 was significantly more E resistant to H₂O₂ when cultured under either 6% or 21% oxygen. However, both MC711-01 and H84O were more susceptible to H₂O₂ when grown under 21% oxygen, indicating that both strains …
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Carbon fiber electrodes for in vivo neural recording
… in mobile parts of the CNS. Although there are studies showing carbon fibers’ superior qualities as a potential electrode material, these studies are mostly restricted to the brain cortex. There is a need for microelectrode designs that can survive long implantation times in the moving parts of …
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Rapid, Quantitative Assessment of Antimycobacterial Water Disinfection based on the Firefly Luciferase Reporter Gene
… luciferase as a reporter gene for disinfection survival studies. Derivatives of M. avium strains MD1 and A5, Mycobacterium smegmatis strain VT307 and Mycobacterium bovis BCG strain Pasteur carrying the firefly luciferase gene (pLUC10) were constructed. In pLUC10-carrying strains of M. avium …
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Novel genotoxins that target estrogen receptor- and androgen receptor- positive cancers : identification of DNA adducts, pharmacokinetics, and mechanism
… ligands for the ER and AR, respectively. Clonal survival studies have shown that hormone receptor expressing malignant cell lines are more sensitive to our compounds than a corresponding receptor deficient line. [¹⁴C]-E2-7[alpha] and [¹⁴C]- 11[beta] have been formulated in Cremophor-EL and …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… (Cysltr1-/-) mice, we conducted time course and survival studies on both C57BL/6 and Balb/C genetic backgrounds. Our findings revealed that the function of CysLTR1 in bacterial infections is influenced by the host's genetic background and gender. Interestingly, CysLTR1 deletion did not impact …
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Role of Extracytoplasmic Function Sigma Factors in Porphyromonas gingivalis
… SigG deficient mutant designated as V3085. Our survival studies showed that both SigH and SigG are essential for P. gingivalis to grow in host cells. Collectively our studies demonstrate that SigH is a positive regulator of gene expression required for survival of the bacterium in the presence …
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The molecular effects of low dose fractionated radiation treatment on Ovarian Adenocarcinoma
… there has not been a marked improvement in survival. These therapies often fail because tumour cells acquire resistance to therapy through mutation: and altered expression of cellular genes. The aim of this project was to investigate a radiation treatment regime that could overcome the …
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Egg quality and fecundity in rainbow trout: the determining factors and mechanisms of control
… R) • Measurements of egg quality, ie. percentage survivals of eggs and fry, from the production batches of eggs of seven fish farms, showed mean survivals of 70% to eying but levels of only 35% to 4.5g fry (approx. 130 days post-fertilisation). Under optimum conditions survivals may reach 85% …
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Enhancement of the An1 Population by BAFF: Potential Role in Autoimmune Disease
… for the homeostasis of B cells. Numerous studies have shown BAFF to be involved in the pathogenesis of autoimmune diseases, including Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis. In an effort to understand the role of BAFF in the pathogenesis of autoimmune diseases, …
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Nesting Ecology Of Red-Headed Woodpeckers (Melanerpes Erythrocephalus) In Central Minnesota
… anywhere in the species’ range, and the few studies that have addressed nest success have not monitored nests through the entirety of the nesting cycle. The objectives of my study include estimating nest success, documenting the extent and timing of brood reduction, and detailing …
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Rheological Studies of Injectable Thermoresponsive Biodegradable Hydrogels and Porcine Ocular Tissues
… a concentration up to 15 mg·mL-1, and in vitro survival studies using MTT and DAPI indicated that both DPSCs and ADSCs have favorably adhered and proliferated within the dextran and HA-based hydrogels. Survival of the DPSCs/ADSCs in the hydrogels, growth and morphology make these scaffolds a …
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Detection and survival of Escherichia coli O157:H7 in cattle water troughs and the effects of cetylpyridinium chloride against Escherichia coli O157:H7 biofilms on the surface of stainless steel
… cattle farms in Louisiana and also to study the survival and growth characteristics of different strains of E. coli O157:H7 in cattle water trough sediments using experimental microcosms. Escherichia coli O157:H7 can form biofilms on food contact surfaces and is responsible for several outbreaks …
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Effect of Storage on the Elastic Properties of the Red Cell Membrane
… for the preservation of blood is the optimal survival and function of the stored blood after reinfusion. In vivo means of assessing viability after storage would be ideal but these survival studies are expensive, involved, and not without danger. Thus, in vitro means have been sought to …
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Phylogenetic studies into the development of foetal tissues and their neoplastic derivatives
… exposure to mutagens and strategy for optimising survival. Studies into normal and neoplastic tissues in adults have delineated clonal architecture and oncogenesis at an exquisite resolution. However, for over a century, data have indicated that childhood cancer is rather different, most likely …
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Local exposure and efficacy of a reservoir-based drug delivery device
… radiotherapy or chemotherapy, and improve median survival time by only a few months. Efforts to develop local treatment modules are motivated by the fact that patients experience systemic toxicities during conventional treatment. Implantable Gliadel® BCNU wafers were approved by the FDA, but …
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Investigation of the Efficacy of a Novel CsA Formulation Alone or in Combination with Cell Therapy in a Humanised Mouse Model of GvHD
… shown this enhanced efficacy using pre-clinical survival studies, histopathology and cytokine analysis and hypothesise that this enhancement over these conventional CsA drugs is mediated through targeted delivery to systemic and GI tissues. Therefore, making it a highly attractive candidate for …
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