Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Surface glycoproteins"”.
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Characterization of Metastasis-Associated Cell Surface Glycoproteins in Prostate Cancer
… at a site distal to the primary tumors. Cell surface glycoproteins play pivotal roles as recognition molecules in a range of cell communication and adhesion events. Aberrant cell surface glycosylation has been reported in various cancers including PCa, and strongly correlated with prognosis …
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Rat Lymphocyte Surface Glycoproteins Mediating Mitogenesis by Periodate or Neuraminidase Plus Galactose Oxidase
… and characterization of rat lymphocyte surface components involved in mitogenic stimulation by the oxidative agents periodate and neuraminidase plus galactose oxidase (NGO). Lymph node cell blastogenesis induced by these oxidative agents was inhibited by reduction with borohydride or …
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Investigation of the interactions between Trypanosoma congolense invariant surface glycoproteins and components of the mammalian immune system
… extracellular in vertebrate hosts, their cell surface forms the primary host-pathogen interface. Invariant surface glycoproteins (ISGs) are a large family of cell surface proteins with recent expansion and diversification in *Trypanosoma congolense*. *Trypanosoma brucei* ISG65 is known to be a …
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Isolation and partial characterization of host cell wall surface glycoproteins: their involvement in agglutination, attachment and appressorium formation by piptocephalis virginiana
Cell surface proteins obtained by alkaline extraction from isolated cell walls of Mortierella pusilla and M. candelabrum, host and nonhost, respectively, to the mycoparasite, Piptocephalis virginiana, were tested for their ability to agglutinate mycoparasite spores. The host cell wall protein …
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MS-Based Chemical Proteomics Studies of Extracellular Glycoproteins: Identification, Quantification, and Dynamics
Extracellular proteins, including cell-surface and secreted proteins, play crucial roles in cell-cell communication, cell-matrix interactions, and the regulation of most extracellular biological processes. The majority of these proteins, if not all, are glycosylated, which affects their functions, …
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Investigation of conventional and unconventional protein secretion using galectin-3
… does not require unfolding or binding to cell surface glycoproteins to be secreted. Galectin-3 was also used to assess protein secretion using a genome-wide CRISPR screen. As galectin 3 binds to cell surface glycoproteins, galectin-3 on the cell surface was used to assess secretion of these …
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UNDERSTANDING THE MOLECULAR BASIS OF CELL DEATH MEDIATED BY ONCOSIS-INDUCING CYTOTOXIC ANTIBODIES
… TO BLOOD GROUP H TYPE-1 EXPRESSED ON MULTIPLE GLYCOPROTEINS ON THE PLASMA MEMBRANE. MECHANISM OF CYTOTOXICITY WAS FOUND TO INVOLVE DETACHMENT OF THE PLASMA MEMBRANE FROM THE UNDERLYING CYTOSKELETON THROUGH INACTIVATION OF EZRIN, RADIXIN AND MEOSIN, AND PERTURBATION TO CYTOSKELETON ORGANIZATION …
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EXAMINATION OF CD133 AND CD147 AS CANCER STEM CELL MARKERS
… tumor stem cells is thus paramount. The cell surface glycoproteins CD133 and CD147 were examined as potential markers of cancer stem cells found in glioblastoma. Here we found evidence which shows that formation of neurospheres with U87MG glioblastoma cells may be driven by increased …
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Dynamics of Agglutinin -Like Sequence (Als) Protein Localization on the Surface of Candida Albicans
The ALS gene family encodes large cell-surface glycoproteins associated with C. albicans pathogenesis. Als proteins are thought to act as adhesin molecules binding to host tissues. Wide variation in expression levels among the ALS genes exists and is related to cell morphology and environmental …
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Dynamics of Agglutinin-Like Sequence (Als) Protein Localization on the Surface of Candida Albicans
The ALS gene family encodes large cell-surface glycoproteins associated with C. albicans pathogenesis. Als proteins are thought to act as adhesin molecules binding to host tissues. Wide variation in expression levels among the ALS genes exists and is related to cell morphology and environmental …
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Characterization of CEACAM1 Spatial Distribution, Self-association and Dynamics using High-resolution Microscopy Techniques
CEACAMs are cell surface glycoproteins involved in homo- and heterophilic intercellular interactions that control cellular growth, differentiation, tumourigenesis, inflammation and infection. There is growing evidence that CEACAM1 isoforms regulate the cellular response to CEACAM1-mediated …
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Mechanisms underlying cell-to-cell diversity in clonal populations of yeast
… genes regulated by these promoters encode cell-surface glycoproteins that mediate a range of cell-to-cell and cell-to-surface adhesions. Phenotypic diversity in clonal populations of yeast cells is mediated in part by epigenetic silencing of the FLO10 and FLO11 promoters. Silencing of the FLO …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
… action of at least four HSV-1 envelope glycoproteins: gB, gD and the heterodimer gHgL. Dendritic cells (DC) are the most potent antigen presenting cells and are likely to encounter the virus early after entry into the host. HSV-1 readily infects DC leading to a series of both …
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Dissecting Human Antibody Responses Against Influenza A Viruses And Antigenic Changes That Facilitate Immune Escape
… continuously acquire substitutions in the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). These substitutions prevent the binding of pre-existing antibodies, allowing the virus to escape population immunity in a process known as antigenic drift. Due to antigenic drift, …
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Cellular and Molecular Biological Investigations Into the Interaction Between Candida Albicans and the Vaginal Epithelium
… tissue model. The ALS genes encode large cell-surface glycoproteins that are candidates for aiding C. albicans colonization of the vaginal epithelium and/or for promoting development of vaginal disease. Vaginal-specific patterns of ALS gene expression were detected using reverse …
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Histone Modifications in Trypanosoma Brucei
… infection in its mammalian host by switching its surface antigen, thus evading host antibodies, in a process known as antigenic variation. Variant surface glycoproteins (VSG), the surface antigen, are expressed from genes located at as many as 20 Expression Sites (ES), which are present in …
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Imaging studies of glycan mediated breast cancer epithelial cell-endothelial cell interactions
… in the body. Aberrant glycosylation of cell surface glycoproteins in cancer cells has been implicated in promoting cancer metastasis and consequent poor survival of cancer patients. In particular, aberrant glycans terminating in α-N-acetylgalctosamine (GalNAc), specifically recognized by the …
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Telomere Structure and Shortening in Telomerase-Deficient Trypanosoma brucei: Implications for Anitgenic Variation
… host through sequential expression of variant surface antigens. Intriguingly, the genes encoding these antigens are frequently found adjacent to the telomeres. Telomeres are nucleoprotein complexes consisting of tandem DNA repeats and proteins that bind to them. Their function is to protect …
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Sphingomyelinases and Lysosomal Trafficking in Ebolavirus Entry
… are needed to proteolytically cleave the virus surface glycoprotein. This action facilitates fusion between the virus and cell membranes prior to infection. However, it is unclear where fusion occurs in the cell. Furthermore, although EBOV colocalizes with early endosomes and late endosomes, the …
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Characterisation of TAPBPR in immune cells
… or malignant cells. This is aided by cell surface glycoproteins called the major histocompatibility complex (MHC). MHC class I (MHC-I) molecules are polymorphic structures that can display a large repertoire of peptides. Peptide loading occurs in the context of a multi-protein machinery …
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