Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Surface attachment"”.
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Graphitic Surface Attachment by Single-Stranded DNA and Metal Nanoparticles
… X-ray reflectivity shows that DNA on a graphite surface forms an inhomogeneous layer around 1.6 nm thick. The differences between the various thicknesses of few-layer graphene are substantial though often underappreciated. These differences are highlighted in the system of several-nanometer metal …
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Fundamental study of pulse electric field effects on hela cell cultured over extracellular matrix protein micro-patterned surface
… study focused on the effect of protein coated surface, combined with the pulse parameter mentioned above, to look at its effect on HeLa cell when exposed to high voltage. Thus, will lead towards cell surface attachment factors interrogation plus the presence of electric field as the stimulator …
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Bacterial adhesion in structured environments
Biofilms-surface-bound communities of microbes-are a major medical concern, as they can be sources of infection that are difficult to eradicate. Their formation starts with the attachment of bacteria to available surfaces-often implantable biomaterials. The development of materials that prevent …
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Using rigging and transfer to animate 3D characters
… character to associate points on the character surface with bones. For this problem, we present a fully automatic rigging algorithm based on the geometry of the target mesh. Given a generic skeleton, the method computes both joint placement and the character surface attachment automatically. For …
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Phase transfer in a collision between a droplet and solid spheres
… The targeted phase transfer includes the surface attachment, mass of vaporization, heat transfer to droplet and its partition between vaporization and droplet heat-up. Specific experiments were designed and performed to partially validate the model predictions on the droplet-solid phase …
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Understanding PilB, The Type IV Pilus (T4P) Assembly ATPase
… (T4P) is a dynamic long thin fiber found on the surface of many bacterial groups. T4P is a versatile nanomachine; it plays many important roles such as for surface attachment, virulence factor, and surface motility apparatus. This research focuses on understanding the kinetics of PilB, the T4P …
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A bacterial biofilm study: from molecular regulation mechanisms in Escherichia coli to the role of biofilms in mammalian colon cancer development
… regulation of FimE via IscR leads to decreased surface attachment and biofilm dispersal under iron-limiting conditions.</p> <p> Bacterial biofilms also tightly interact with higher organisms. The mammalian gastrointestinal tract harbors a huge number of bacterial cells, with numerous species. …
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Response of indigenous heterotrophic groundwater bacteria to low organic substrate availability
… planktobacteria, they may have no affinity for surface attachment and may rely on dissolved low molecular weight organic substrates in dilute solution for their nutrition. Periods of metabolic dormancy may occur when natural substrate concentrations drop below the level required to sustain …
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Attachment of polyelectrolyte multilayers to cells and the implications on cell behavior
… hundreds of nanometers thick, attached to the surface of a cell. Unlike passive delivery systems, cells have the ability to use signaling and trafficking to actively target a disease site. Cells carrying drug-loaded backpacks would thus be able to efficiently carry drugs to unhealthy cells. The …
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Mucin and mucin glycans alter behaviorof mucosal pathogens
… I determine that mucin decreases K. pneumoniae surface attachment and biofilm formation, major sources of persistent and antimicrobial tolerant infections especially on implanted medical devices. Additionally, I discover that the glycans cleaved from the mucin protein backbone also block K. …
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Impacts of mucins on microbial physiology and interactions
… Many of these organisms inhabit mucosal surfaces, with most found in the large intestines, but many also dwell in the respiratory and urogenital tracts. Despite the enormous microbial population inhabiting the body, some of which are opportunistic pathogens, most people harbor these …
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Modification and Translocation of the Biofilm Exopolysaccharide Poly-β(1,6)-N-acetyl-D-glucosamine
… play an important role in bacterial aggregation, surface attachment, and serve as a protective barrier against antibiotics and host defenses. A key exopolysaccharide required for biofilm formation by a number of pathogenic bacteria is poly-beta(1,6)-N-acetyl-D-glucosamine (PNAG). The modification …
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The influence of mucins on bacterial communities
… In Chapter 2, 1 study the ability of mucin surface coatings to suppress bacterial surface attachment, the first step in biofilm formation, for Streptococcus pneumoniae and Staphylococcus aureus. Mucin-bound glycans were identified as a critical structural component of mucin coatings that are …
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Designing surface chemistries for in situ AFM investigations of biomolecular reactions with proteins at the nanoscale
… self-assembled monolayers, to form a robust surface attachment for sustained contact-mode AFM imaging during biochemical reactions. Staphylococcal protein A (SpA) furnishes a generic foundation for binding immunoglobulins for nanometer scale sandwich assays. The self-assembly of …
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On the depolymerization of actin filaments
… structural transitions of the whole filament to surface attachment of the filament ends. The key issue of this thesis is to elucidate the unexpected interruptions of depolymerization by a combination of experimental and theoretical studies. In new depolymerization experiments on single filaments, …
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Ultrasensitive quantification of circulating disease biomarkers through enzymatic labeling and single molecule counting
… probes as well as the optimization of surface attachment and probe labeling methods. Ultimately this research concludes with the successful detection of labeled miRNA, establishing a framework for advancing the sensitivity of this method toward the fundamental level of digital single …
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Sensing in biological systems
… readily functionalised for analyte selectivity, surface attachment, and tuning of the photochromic properties. Photo-controlled switching between the weakly fluorescent spiropyran (SP) and highly fluorescent merocyanine (MC) isomers occurs on irradiation with UV light or in the presence of the …
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The Type IV Pilus Assembly ATPase PilB as a Regulator of Biofilm Formation and an Antivirulence Target
Bacterial type IV pili (T4P) are filamentous surface appendages with a variety of functions including motility, surface attachment, and biofilm formation. In many species of bacteria a clear understanding of how the functions of T4P in lifestyle switching are regulated remains to be elucidated. …
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Functional Studies of Novel Bioactives From Complex Host-Microbiomes as Drug Leads for Cancer, Infectious Disease, Depression and Pain
… of the oil was evaluated by its effects on surface attachment of a Gram negative bacterial model using confocal fluorescence microscopy as well as its effects on the attachment of Dreissena polymorpha (zebra mussel). The ketone ( n-decan-2-one) inhibited attachment of the bacteria and zebra …
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Cell engineering of human bone monolayers and the effect of growth factors and microcontact printed ECM proteins on wound healing. The role of ECM proteins, TGF¿-1, 2 and 3 and HCl/BSA in cellular adhesion, wound healing and imaging of the cell surface interface with the widefield surface plasmon microscope.
… (HCl and BSA, respectively) effected cell surface interactions, cell morphology, cell proliferation and integrin expression. Finally, this study also aimed at examining how the TGF-¿s and their solvent and carrier influenced wound closure in an in vitro wound closure model and how TGF-¿s …
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