Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Surface antigen"”.
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Structural and antigenic components of Hepatitis B surface antigen
… tests for the detection of hepatitis B surface antigen there is still comparatively little basic inf creation available on the protein, lipid and carbohydrate composition of these particles, and on the arrangement of these components into a stable quaternary structure. In the present …
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Characterization of the Staphylococcus aureus Immunodominant Surface Antigen B, IsaB
… Lorenz et al first described the Immunodominant Surface Antigen B, IsaB, because it was 1 of 4 unique proteins immunogenic during septicemia and not colonization, suggesting that IsaB may be a virulence factor and a possible novel therapeutic target. Interestingly, IsaB has no homology to …
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Identification and characterization of a novel capsule-like complex surface antigen of Francisella tularensis
… and characterize the capsule-like complex (CLC) surface antigen of F. tularensis, and to determine its role in virulence and immunoprotection in a mouse model. In addition, I have investigated the role of CLC in biofilm formation. The CLC appears as a negatively staining material surrounding F. …
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Molecular characterization of a gene that is associated with Listeria monocytogenes serotype 4b-specific surface antigen expression
… found to be involved in serotype-specific surface antigen expression of L. monocytogenes serotype 4b. One mutant, 27B6, derived from L.monocytogenes serotype 4b strain 2381L (Jalisco cheese outbreak), was found to be negative in immunoblot reactions with all three serotype 4b-specific MAbs …
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Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment
… treatment outcomes. The rITs were targeting cell surface biomarkers, Trophoblast cell surface antigen 2 (TROP2) and mesothelin (MSLN), which are overexpressed in cervical cancer cells. Targeting TROP2 and MSLN presents a promising therapeutic approach. The study aimed to develop novel recombinant …
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Epidemiology, molecular characterisation and tropism of the Hepatitis G Virus / GBV-C
… of antibodies to hepatitis A lgG, hepatitis B surface antigen and antibodies to hepatitis B surface antigen were 98%, 4.3% and 61.1 % respectively. The mean prevalence of antibodies to hepatitis C was 1.8%. No significant differences in prevalence were shown between the urban and rural regions …
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Histone Modifications in Trypanosoma Brucei
… infection in its mammalian host by switching its surface antigen, thus evading host antibodies, in a process known as antigenic variation. Variant surface glycoproteins (VSG), the surface antigen, are expressed from genes located at as many as 20 Expression Sites (ES), which are present in …
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T-cell-directed bioorthogonal catalysis for localised prodrug activation in cancer therapy
… in which T-cells, engineered to express a surface protein upon cancer recognition, are used as an inducible antigen to recruit antibody-catalysts that facilitate drug activation in tumour proximity. To demonstrate this concept, we integrated a bioorthogonal catalyst with a single-domain …
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Synthesis of fragments of the capsular polysaccharide of <i>Neisseria meningitidis</i> (serogroup A) suitable for bioconjugation
… (CPS) and apart from being an important surface antigen, also protects the bacteria cells against phagocytosis by the host’s immune defense. The CPS structure of the serotype A is the (1-6)-linked poly(3-O-acetyl-2-acetamido-2-deoxy-a-D-mannosyl phosphate):<br/>A potential route towards a …
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Experimental infection with Sarcocystis neurona alters the immune response: the effect on CD4+, CD8+, B-cell, monocyte and granulocyte populations in horses
… neurologic examinations, SnSAG1 (S. neurona Surface Antigen 1) ELISAs on cerebrospinal fluid (CSF) and serum, and baseline immune function assays were performed. Horses were randomly divided into groups. Five horses were challenged for ten days via intravenous injection of autologous …
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Modelling hepatotoxicity in HIV/TB co-infected patients: extensions of the Cox Proportional Hazards Model
… bilirubin and a positive baseline Hepatitis B surface antigen status, were associated with a higher risk of developing the first occurrence of hepatotoxicity. The extended Cox models (AG model, Shared frailty model, PWP TT model and PWP GT model) in combination identified that: time-varying …
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Targeting the B-Cell Receptor in Diffuse Large B-Cell Lymphoma
… express a B-cell receptor (BCR), which is a cell surface antigen receptor of immunoglobulin in tandem with the signalling adapters CD79A and CD79B. Over the last 2 decades, the importance of signals emanating from the BCR have gained prominence in how we understand oncogenic signalling in DLBCL. …
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Modelling biological networks : topology, dynamics and generation
… to be associated with the lengths of a family of surface antigen genes. This dynamic behaviour was interpreted as a ‘feint attack’ diversion tactic utilised during infection by these persistent parasites, allowing the infection to out-maneuver the host immune system. In addition to investigating …
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To Stop or Not to Stop: Response After Nucleos(t)ide Analogue Withdrawal Among Patients With Chronic Hepatitis B
… require lifelong treatment, and hepatitis B surface antigen (HBsAg) loss, or “functional cure” is rare on therapy. NA withdrawal results in higher rates of HBsAg loss but remains controversial because of the possibility of HBV flares. This thesis aims to investigate long-term outcomes after …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
… One such strategy is DNA vaccination whereby the antigen is synthesized in vivo after direct introduction of its encoding sequences. In this thesis, we show that the route of administration of plasmid DNA encoding the hepatitis B surface antigen (HBsAg) influences the strength and nature of immune …
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Modulation of Immunity via Antibodies Displayed on in situ Forming Peptide Co-assemblies
… Monoclonal antibodies (mAb) targeting soluble antigens or immune cell surface molecules have been developed to modulate immunity. However, systemic administration can lead to severe immune related side effects. This dissertation investigated a versatile platform to display antibodies locally in …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… Simultaneous cell cycle and cell surface antigen analysis showed that the CD11b marker is expressed in all phases of the cell cycle. Similarly, analysis of CD11b coupled with the intranuclear proliferation antigens, PCNA and Brdu, revealed that proliferation antigens are also …
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Functional characterization of mobilized tumor cells
… delineates the tumorigenic population with surface markers using MPEs. A total of 35 surface antigens were screened from four categories: 1) cancer stem cell 2) epithelial-mesenchymal transition 3) metastatic signature and 4) tyrosine kinase receptors. Surface antigen CD24 was found to be …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
… phenotypic changes detected by CD4 and CD8 surface antigens, and progenitor T-cell targeting in the fetal mouse. We hypothesized that gestational exposure to these two compounds may lead to comparable histologic and gene expression alterations in the fetal mouse thymus and liver. Treatment …
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