Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Supranuclear"”.
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Progression and variation of Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a devastating neurodegenerative disorder with poor prognosis. The development of novel therapeutics has been hindered by long delays from symptom onset to diagnosis, marked heterogeneity, and uncertainty over the optimal outcomes in early-phase clinical …
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Synaptic loss in the primary tauopathies of Progressive Supranuclear Palsy and Corticobasal Degeneration
… in the primary tauopathies of Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD). Both PSP and CBD are associated with an accumulation of 4-repeat tau in cortical and subcortical areas. As well as movement disorders, they impair cognitive function, even where there is …
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The role of tau and neuroinflammation in Progressive Supranuclear Palsy and Alzheimer's Disease
… pathology and neuroinflammation in Progressive Supranuclear Palsy (PSP) and Alzheimer’s disease (AD) ‘in vivo’ and to validate it using post mortem data is critical to develop reliable biomarkers for these disorders, and for tracking the effects of clinical trials using disease-modifying …
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Digitally quantified neuropathological correlates of structural and functional imaging biomarkers in progressive supranuclear palsy
… different tauopathies. With this, progressive supranuclear palsy (PSP) is a prime disease for investigating the relationship between imaging changes and tau burden. Early studies have revealed that semi-quantitative pathological tau measures are predictive of *in vivo* atrophy but is less …
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Análises de redes modulares de co-expressão gênica revelam vias importantes na doença de Alzheimer e paralisia supranuclear progressiva
… diseases (Alzheimer or Progressive Supranuclear Palsy) and two animal models, 5XFAD of amyloidopathy and TauD35 of tauopathy, we performed an integrative analysis at the gene/transcript level combined with a co-expression analysis to identify similarities and discrepancies in the …
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Imaging Correlates of Heterogeneity in the Syndromes Associated with Frontotemporal Lobar Degeneration
… two multi-site collaborations, the Progressive Supranuclear Palsy Corticobasal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M-UK) and the Genetic Frontotemporal Dementia Initiative (GENFI). I describe characteristic differences in markers derived from task-free functional MRI …
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Apathy and Impulsivity in Frontotemporal Lobar Degeneration Syndromes
… including frontotemporal dementia, progressive supranuclear palsy and corticobasal syndrome. They cause substantial patient morbidity and carer distress, often coexist and are undertreated. Using data from the Pick’s disease and Progressive supranuclear palsy Prevalence and INcidence (PiPPIN) …
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Genetic Characterisation of Neurodegenerative disorders
… (AD), Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). On strong evidence that several genes may influence the development of sporadic neurodegenerative diseases, the genetic association approach was used in the work of this thesis to …
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Characterization of Tau Oligomeric Strains: Implications for Disease Phenotypes
… toxic tau oligomers are elevated in progressive supranuclear palsy, traumatic brain injury and synucleinopathy models and reversal of toxicity can be achieved with treatment of a tau oligomer-specific monoclonal antibody. Tau oligomers have prion-like properties, enabling them to seed the …
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Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
… disease, PiD), four repeats (4R, Progressive supranuclear palsy, PSP; corticobasal degeneration, CBD; others), or a combination of 3R/4R tau aggregates (Alzheimer disease, AD; chronic traumatic encephalopathy, CTE; primary age-related tauopathy, PART). This work details several methods for the …
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Behavioural disinhibition in the syndromes associated with frontotemporal lobar degeneration
… of primary progressive aphasia, progressive supranuclear palsy and corticobasal syndrome. Multivariate analyses of clinical features and brain morphometry identified components that showed considerable overlap across the diagnostic groups. The transdiagnostic components of clinical features …
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Connectivity biomarkers in neurodegenerative tauopathies
… cognition. In this thesis I study Progressive Supranuclear Palsy (PSP) and the Corticobasal Syndrome (CBS), two parkinsonian disorders associated with accumulation of hyperphos- phorylated and abnormally folded tau protein. I contrast these two disorders with Parkinson’s disease (PD), which is …
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Characterization of a Novel NPC1I1061T Knock-in Mouse Model of Niemann-Pick Type C1 Disease
… symptoms that include ataxia, vertical supranuclear gaze palsy, and decreased motor function. Most NPC1 patients succumb to the disease within the first two decades of life.</p><p>The most prevalent mutation, NPC1<super>I1061T</super>, resides within the cysteine-rich luminal domain of …
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Analysis methods for gravitational wave from binary neutron star coalescences: investigation on the post-merger phase
… to probe matter up to yet unknown and unexplored supranuclear densities, provided that the signal-to-noise ratio (SNR) at which the single GW is detected is sufficiently high or that the results from more detections can be combined together. Depending on mass and Equation of State (EoS) of the NS …
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Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
… disease, Pick's disease, and progressive supranuclear palsy. In the adult human brain, six isoforms of tau are expressed that differ by presence or absence of the second of the four semiconserved repeats. As a consequence, half of the tau isoforms have three repeats (3R tau), whereas the …
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The daily rhythm of Paneth cells in <i>Mus musculus </i>
… located, often deeply indented nucleus, a supranuclear Golgi apparatus, and secretory granules in the supranuclear region and apical cytoplasm.</p> <p>Paneth Cell Ultrastructure</p> <p>The Paneth cell secretory granules of rats (Erlandsen and Chase 1972 a and b) and men (Trier 1963, …
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Evaluating the efficacy of brewers’ yeast-derived functional feed additives in mitigating soybean meal-induced enteritis in Atlantic salmon
… preserved mucosal folds, relatively intact supranuclear vacuoles, and reduced microvilli damage. Gene expression analysis indicated reduced epithelial stress and enhanced regenerative capacity in these groups. Although, the higher 2.5% YE dose provided only moderate additional benefit, …
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Myasthenia Gravis mimics: An audit of cases identified at Groote Schuur Hospital over 20 years
… probable muscular dystrophy (MD), 1 progressive supranuclear palsy and 1 with a multiple sclerosis brainstem relapse. Median age at symptom onset was 10 years for CMS, 18 for mitochondrial cytopathies, 53 for FNS, 58 for the muscular dystrophy cases and 63 years for those with MND. The median …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… (HD), Alzheimer disease’s, and progressive supranuclear palsy. Mutant huntingtin (htt) and small G proteins (e.g. Rac 1) are potential substrates of TGases. The purpose of this dissertation was to characterize the mechanisms by which 5-HT2A receptor signaling and calmodulin (CaM) regulate …
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
… (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each characterised by neuroinflammation, with increasing evidence that the neuroinflammation plays a role in the onset and progression of these diseases, rather …
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