Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Suprachiasmatic nuclei"”.
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Suprachiasmatic nuclei development: A characterization of transcription factors and the influence of retinal innervation and VIP signaling
The suprachiasmatic nuclei: SCN) are highly specialized neural structures with an essential behavioral function; creating the rhythm of the mammalian central clock and entraining that internal clock to the external world. The nuclei each consist of approximately 10,000 neurons, each capable of …
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In vitro studies of the role of cyclic-AMP in the mammalian circadian clock in the suprachiasmatic nuclei
… the primary circadian clock is located in the suprachiasmatic nuclei (SCN) of the brain. My research investigated the biochemical mechanisms underlying this clock, focusing in particular on the potential role of cAMP.
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Central Cardiovascular Effects of Arginine Vasopressin in the Lateral Habenular Region in Anesthetized Rats
… fibers extending from the paraventricular and suprachiasmatic nuclei in the hypothalamus to other brain structures. The lateral habenular region in the rat brain has been shown to specifically receive vasopressinergic, but not oxytocinergic, fibers from the suprachiasmatic nuclei. The …
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Cholinergic regulation of a mammalian circadian clock
… mediating this action have been unknown. The suprachiasmatic nuclei (SCN), the primary circadian pacemaker in mammals, continue to show a circadian rhythm in neuronal activity in a hypothalamic brain slice. Using this in vitro preparation, we investigated the direct regulation of the SCN …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… central pacemaker located in the hypothalamic suprachiasmatic nuclei (SCN) synchronizes the peripheral clocks in different tissues. This dissertation aims to uncover specific circadian regulatory mechanisms in the brain and skeletal muscle.</p> <p>Alzheimer’s Disease (AD) is the most common …
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Non-Photic Phase Shifting: Acetylcholine and Arousal
… capable of producing large phase advances of the suprachiasmatic nuclei (SCN) during the midday in a manner that is different than light. Two prominent non-photic stimuli include confinement to a novel running wheel, and sleep deprivation by gentle handling. It was hypothesized that these stimuli …
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Windows in the clock: An in vitro study of melatonin action and signal transduction in the suprachiasmatic circadian pacemaker
… hormone, melatonin, may act at the level of the suprachiasmatic nuclei (SCN) in mammals to regulate the functioning of this primary circadian pacemaker. By isolating the rat SCN in vitro in a hypothalamic brain slice preparation, we have demonstrated a direct resetting of the SCN pacemaker's …
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Temporal Changes in the Levels of Gamma-Aminobutyric Acid in the Brain of the Cockroach, Leucophaea Maderae
… output may be inhibitory. In vertebrates, the suprachiasmatic nuclei (SCN) is the site of the biological clock, and it has been shown that gamma-aminobutyric acid (GABA) plays an important role in the vertebrate circadian system. The importance of GABA in the vertebrate SCN and its presence in …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… The master circadian pacemaker is the suprachiasmatic nuclei (SCN) in the anterior hypothalamus. There are circadian oscillators in numerous brain areas and peripheral organs and tissues. NF-κB is composed of dimers of members of the Rel family, including p65 (RelA), p50, p52, c-Rel and …
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Investigating Anatomical and Neurochemical Topology of the Mammalian Suprachiasmatic Nucleus
… such circadian timing is governed by the suprachiasmatic nuclei (SCN) containing approximately 20,000 cells which are heterogeneous in their expression of signalling molecules, rhythmic properties and connectivity to one another. It is through emergent network properties that the diversity …
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Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation
… by the master circadian (daily) clock in the suprachiasmatic nuclei ( SCN). Signaling in this regard is at least partially responsible for entraining circadian clocks outside of the SCN. Just as shifts in glucocorticoid exposure are associated with metabolic disturbances, disruption of …