Global ETD Search
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Showing 1 to 20 of 41 for “"Suprachiasmatic Nucleus: SCN"”.
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Fetal tissue containing the suprachiasmatic nucleus restores circadian rhythms in old rats
… rats deteriorate or even disappear with age. The suprachiasmatic nucleus (SCN) in the anteroventral hypothalamus has been identified as the major circadian pacemaker in mammals. When fetal tissue containing the SCN is transplanted into young rats whose circadian rhythms have been abolished by SCN …
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The role of redox oscillation in circadian physiology of the suprachiasmatic nucleus and hippocampus
The suprachiasmatic nucleus (SCN) of the hypothalamus is the master regulator of the circadian clock in mammals. It generates daily rhythms of behavior, metabolism, and other important physiological processes. Misalignment of this internal circadian clock with the external environment can lead to …
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Circadian rhythms of redox state and regulation of neuronal excitability in suprachiasmatic nucleus of rodents
… by the central circadian clock in the brain, the suprachiasmatic nucleus (SCN), where a genetic oscillator plays an essential role. Clock-gene transcription/translation is sensitive to metabolic (redox) change; however, energetic cycles manifest as circadian rhythms in protein oxidation have been …
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Circadian Timekeeping of Body Temperature by the Mammalian Suprachiasmatic Nucleus
… peripheral clocks in mammals. The hypothalamic suprachiasmatic nucleus (SCN) is required for generating the ~24-hour rhythms of body temperature (Tb); however, the neural mechanism underlying this regulation remains poorly understood. Here, we searched for circadian clocks in the SCN that are …
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Pituitary Adenylate Cyclase -Activating Peptide Signaling in the Mouse Circadian Clock
… the endogenous period of circadian rhythms. The suprachiasmatic nucleus (SCN) of the hypothalamus is the mammalian circadian pacemaker, which can be studied in an isolated slice preparation. Measurement and replacement of glutamate-induced signaling components to the SCN slice indicate that a …
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Caffeine and Human Perception of Time
… of the brain's internal clock, controlled by the suprachiasmatic nucleus (SCN), which is believed to mediate the perception of short durations, is sensitive to a variety of stimuli including stimulants. This study expands on previous research on the effect of caffeine on prospective time …
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Regulation of Circadian Rhythms by Sleep -Wake Centers in the Brainstem and Basal Forebrain
… cycle, and in mammals are regulated by the suprachiasmatic nucleus (SCN). The proper interaction of the circadian and sleep-wake cycles is essential for well-being, but the means by which these processes interact is unknown. The nucleus basalis magnocellularis (NBM) in the basal forebrain, …
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The Role of Atypical PKC in the Plasticity of the Circadian Clock in the Rat Suprachiasmatic Nucleus
… master circadian clock, which locates within the suprachiasmatic nucleus (SCN) of the hypothalamus. The endogenous circadian rhythms generated by the SCN are actively synchronized by the environmental light. The photic signals are transferred by the excitatory neurotransmitter, glutamate (GLU), …
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Spring Forward or Fall Back? Redox State as a Determinant in Glutamate Signaling Pathways Adjusting Our Brain Clock
The suprachiasmatic nucleus (SCN) of the hypothalamus is the master circadian clock in mammals. Nocturnal light, acting via neurotransmitter glutamate, synchronizes this clock to changes in the external environment by adjusting the phase of the SCN. The phase-resetting response depends on the …
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Investigation of the SCN 2.2 Cell Line as a Model of the Central Mammalian Circadian Pacemaker
The SCN 2.2 cell line, derived by immortalization of fetal rat suprachiasmatic nucleus (SCN) tissue, was investigated for characteristics of the SCN, which is the central mammalian circadian pacemaker. Extensive characterization of differentiated SCN 2.2 cultures revealed that this cell line …
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Characterizing cerebellin-short, a novel circadian peptide, in the rat suprachiasmatic nucleus
… the sleep/wake cycle, are orchestrated by the suprachiasmatic nucleus (SCN) located in the hypothalamus. Mass spectrometry peptidomics of the SCN identified the small peptide cerebellin-short (SGSAKBSAIRSTN) consisting of 15 amino acids, which is released from the SCN in circadian fashion. …
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The Role of SOX2 in Molecular Circadian Clock Regulation and Suprachiasmatic Nucleus Development
… Sox2 expression. One of such regions is the suprachiasmatic nucleus (SCN), that contains the mammalian central circadian clock. The 20,000 clock neurons in the SCN are responsible for interpreting photic signals and orchestrating oscillations in peripheral tissues. In this study, I …
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Diurnal and stimulated astrocyte morphology dynamics in the rodent central nervous system
… of the hippocampal dentate gyrus (DG) and suprachiasmatic nucleus (SCN). Glial fibrillary acidic protein (GFAP) branch terminal-points are significantly less numerous in the DG than the SCN. Terminal-points increase and decrease in complexity throughout the day-night cycle. Branching peaks …
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MELANOPSIN AND PACAP IN INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS REGULATE THE DEVELOPMENT OF RETINOFUGAL PROJECTIONS IN MICE
… in development of retinofugal projections to the suprachiasmatic nucleus (SCN) and refinement of eye-specific segregation in the dorsal lateral geniculate nucleus (dLGN) have not been extensively determined. To answer these questions, I used tract tracing with eye injections and mesoscale imaging …
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Modeling the interactions between the circadian clock, dopamine, and metabolism
… (DA). The circadian clock circuitry in the suprachiasmatic nucleus (SCN) drives 24-hour rhythms in many important physiological processes, including the dopaminergic system. DA imbalances have been linked to various neurological and psychiatric conditions such as Parkinson's disease, …
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Photic entrainment and induction of immediate-early genes within the rat circadian system
… expression of these two genes within the suprachiasmatic nucleus (SCN) correlates both in magnitude and in the temporal contingency with light-induced behavioral phase shifts. The determination of the role of Fos and Jun-B in circadian clock resetting was previously attempted using light …
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Molecular Mechanisms of Melatonin Action on the Rat Suprachiasmatic Nucleus: An in Vitro Analysis
… are synchronized to the solar cycle by the suprachiasmatic nucleus (SCN) of the mammalian brain. Cells of the SCN undergo a near 24-hour pattern of cellular events that convey time-of-day information to target organs. The endogenous nature of this dock is based in a molecular feedback loop …
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Role of Aryl Hydrocarbon Receptor in Circadian Rhythm: A Novel Pathway to Dioxin Toxicity
… of AhR and its signaling targets in the suprachiasmatic nucleus (SCN), the master clock, and in the liver, a peripheral clock, were determined in mice. The circadian phenotype was also characterized in mice lacking AhR. Although not robust as some of the well-characterized clock genes, …
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Time of Day Influences on Gonadotropin Releasing Hormone Neurons
… with cognate peptides that are expressed in the suprachiasmatic nucleus SCN. A separate but related group of experiments attempted to isolate a pure population of GnRH neurons from GnRH-eGFP transgenic mice by florescence activated cell sorting (FACS) and analyze the mRNA of this population by …
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Functional Organization and Information Processing Within the Suprachiasmatic Nucleus Assessed by Multiunit Recording in Vitro
The rat suprachiasmatic nucleus (SCN) contains a network of interconnected cellular circadian pacemakers. The functional organization of circadian pacemaker activity, and information processing in the SCN were examined using electrophysiological methods in vitro. A novel carbon fiber bundle (CFB) …
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