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Showing 1 to 20 of 25 for “"Supporting Cells"”.
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Cochlear hair cell regeneration from neonatal mouse supporting cells
… but the specific source of these new hair cells has been unclear. Here, using in vitro lineage tracing with the supporting cell markers Sox2 and Lgr5, we show that Lgr5-positive inner pillar and 3rd Deiter's cells in gentamicin-damaged organs of Corti from neonatal mice give rise to new …
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In vivo physiology of gap junctions between supporting cells in the organ of Corti
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.
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Combination of Compounds A2CE and C18 for Cochlear Hair Cell Regeneration in Adult Mice
… explore to restore normal hearing function. Hair cells are a specialized cell type in the inner ear that are crucial for transducing sound into electrical signals that our neurons can interpret. They are post-mitotic, which means once they die or are damaged, they do not regenerate. Previous …
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The canonical Wnt signaling pathway affects regeneration of mechanosensory hair cells in Danio Rerio
In vertebrates, mechanosensory hair cells are located in the inner ear and mediate hearing. When damage to these specialized cells occur, it leads to irreversible hearing loss. Not only do aquatic vertebrates have inner ear hair cells, but mechanosensory hair cells are also found in the lateral …
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THE ROLE OF NOTCH SIGNALING IN THE DIFFERENTIAL ABILITY OF SUPPORTING CELL SUBTYPES TO SPONTANEOUSLY REGENERATE HAIR CELLS IN THE NEONATAL MOUSE COCHLEA
… loss in hearing is the loss of the sensory hair cells (HCs) within the cochlea. Also in the mammalian cochlea, six major groups of supporting cell (SC) subtypes reside in close proximity to HCs and may have the potential to regenerate HCs after damage. These subtypes include cells of the greater …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
… causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. The compound promotes the initial stages of the proliferative regeneration of hair cells, a process thought to be permanently suppressed in the …
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Characterization of the Key Mouse Cochlear Developmental Genes for Auditory Hair Cell Regeneration
<p>Mammalian inner ear cochlear auditory hair cells (HCs) and adjacent supporting cells (SCs) are believed to derive from the same progenitors during development. However, unlike SCs of nonmammalian vertebrates, mammalian cochlear SCs cannot be converted into functional hair cells (HCs) after …
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Examining the roles of resident non-myogenic mesenchymal cell populations in skeletal muscle development and injury
… from both myogenic and their supportive niche cells. The muscular niche is complex. At the cellular level it is composed of a broad number of cell types including: endothelial vessels, nerve and nerve-supporting cells, resident immune populations, and a heterogenous group of non-myogenic …
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Development of Quantitative Tools for the Characterization and Analysis of the Blood Brain Barrier in Normal and MPS IIIB Mice
… at the borders of adjoining cerebral endothelial cells known as the tight junctions (TJs) and the relationship of other supporting cells and proteins such as astrocytes, pericytes, microglia, and the basement membrane and extracellular matrix proteins associated with the endothelial cells. While …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… from the vestibular efferent terminals onto hair cells is acetylcholine (ACh). Two types of acetylcholine receptors (AChRs) have been suggested to be located on hair cells (HCs). They were nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs). Even though pioneering physiological and …
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A Smart Solution for Tissue Engineering Applications
… any proteolytic enzyme. The gelatine sheet supporting cells, differently from the “Okano” cell sheet method, could be also directly implanted in-vivo without any need for removal, due to the gentle melting of the gelatine sheet after implantation. Thirdly, gelatine gels were used as depot to …
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Defined populations of inner ear progenitor cells show limited and distinct capacities for differentiation into hair cells, neurons, and glia
Despite the fact that mammalian hair cells and neurons do not naturally regenerate in vivo, progenitor cells exist within the postnatal inner ear that can be manipulated to generate hair cells and neurons. This work reveals the differentiation capabilities of distinct inner ear progenitor …
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Upregulation of Reactive Oxygen Species During The Retrovirus Life Cycle and Their Roles In A Mutant of Moloney Murine Leukemia Virus, Ts1-Mediated Neurodegeneration
… since they are retroviral reservoirs and supporting cells for neurons. It has been shown that <em>ts</em>1 is able to infect astrocytes <em>in vivo</em> and <em>in vitro</em>. Astrocytes, the dominant cell population in the CNS, extend their end feet to endothelial cells and neuronal …
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Decoding Dynamic Gene Regulation in Hair Cell Development and Regeneration
… during the differentiation of specialized cells such as mechanosensory hair cells in vertebrates' inner ears and fishes' lateral lines requires an accurate description of the time-lagged relationships between transcription factors and their target genes. Here I describe <em>De</em>picting …
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The Roles of Ca2+ and cAMP in the Nematocyst Discharge of the Sea Anemone Tentacle
… that capture prey using specialized stinging cells called cnidocytes. The cnidocyte contains a nematocyst, which is a capsule containing an inverted, hollow tubule. Prey contacting the tentacle triggers the nematocyst tubule to rapidly evert; a process called discharge. The everting tubule …
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Effects of voluntary wheel running and forced treadmill running on inflammation induced behavioral abnormalities in young and old mice
… act directly or indirectly on neurons and supporting cells to alter autonomic nervous system output, endocrine system output, and behavior to regulate the body’s response to infection. One host factor affecting the behavioral response to infection is aging. Due to microglia priming and …
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Experimental Measurement of the Utricle's Dynamic Response and the Mechanoelectrical Characterization of a Micron-Sized DIB
… The base layer contains a set of neural receptor cells, called hair cells, and supporting cells. The three layers above the base layer compose the utricle's otoconial membrane (OM) and are: 1.) a saccharide gelatinous layer, 2.) a column filament layer, and 3.) a calcite and aragonite otoconial …
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Expression Analysis of the Regenerating Utricle Sensory Epithelia : From Macroarrays to Parsing Pathways
… epithelium from each organ is made up of hair cells and supporting cells. These hair cells are necessary for the detection of sound in the cochlea and for the detection of movement and acceleration in the utricle. The chicken sensory epithelia is of great research interest as it possesses the …
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EXPRESSION AND MISEXPRESSION OF THE MIR-183 FAMILY IN THE DEVELOPING HEARING ORGAN OF THE CHICKEN
… for the proper maturation of primary sensory cells in both the inner ear and the retina in mammals. The miR-183 family shows dynamic longitudinal and radial gradients in the developing mouse cochlea, which raises a question whether the microRNA levels play a role in specifying hair cell …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. In mammals, inner ear sensory cells undergo terminal mitosis during embryogenesis and do not regenerate. Therefore, during postnatal life, sensory cell loss is a …
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