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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Superparamagnetic Iron Oxide Nanoparticles"”.
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Engineering Superparamagnetic Iron Oxide Nanoparticles for Environmental Applications
<p>Engineered, superparamagnetic iron oxide nanoparticles (IONPs) have drawn considerable research attention for a broad range of applications based on tunable size and shape, surface chemistries, and magnetic properties. For successful aqueous-based, environmental applications, it is necessary to …
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Magnetic resonance thermometry with superparamagnetic iron oxide nanoparticles
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Thermally Responsive Peptide Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery
… sites and trigger drug release. In this context, superparamagnetic iron oxide nanoparticles based drug delivery systems are highly desirable. Superparamagnetic iron oxide nanoparticles upon exposure of alternate magnetic field could be directed and provide heat to localised areas. Moreover, …
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Development of Novel Synthetic Methods for Size-Tunable Synthesis of Superparamagnetic Iron Oxide Nanoparticles
The properties of magnetic nanoparticles vary dramatically with size, so reproducibly controlling size is critical for practical applications. This is particularly true when moving into clinical settings, where regulatory approval requires demonstrated reproducibility in efficacy that can only be …
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Purification of human dna for dna profiling from body fluid contaminated soil using superparamagnetic iron oxide nanoparticles (spions).
… extraction method, and a method employing superparamagnetic iron oxide nanoparticles (SPIONs) generated in-house. Extraction success and level of purity of the human DNA extracted using these methods were assessed by quantifying the amount of DNA recovered using a Nanodrop 2000 and the …
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Fundamental studies and applications for the development of novel MRI contrast agents: Hyperpolarized xenon-129 and superparamagnetic iron oxide nanoparticles
… contrast agents: hyperpolarized 129Xe gas and superparamagnetic iron oxide nanoparticles (SPIONs). The largest `Achilles' Heel' of MR techniques is their inherent lack of detection sensitivity due to the exceedingly small magnitude of the nuclear spins, giving rise to small thermal …
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Magnetic targeted drug delivery system in gene therapy
… covers the synthesis and characterization of superparamagnetic iron oxide nanoparticles and summarizes the research process of polymeric coating as a function of gene vectors. Nuclear magnetic resonance technology is used to identify the structure of the polymer step by step. At last, the use …
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Synthesis and development of hydrophilic iron oxide nanoparticles for biomedical applications
Uniformly sized superparamagnetic iron oxide nanoparticles (SPIONs) with inorganic diameters of 3-35 nm were synthesized. New surface ligand coatings were designed and synthesized, and the resulting hydrophilic SPIONs in biological buffers were found to be compact, stable, highly magnetic, and …
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Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres
… imaging modality that specifically detects superparamagnetic iron oxide nanoparticles (SPIOs). Our lab has shown that cell tracking with magnetic resonance imaging (MRI) has very high sensitivity, but low specificity and quantification of iron labeled cells is difficult. MPI cell tracking …
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Evaluation of nanoparticles-based thermotherapy for cancer
Under alternating magnetic field, superparamagnetic iron oxide nanoparticles can be used to generate heat for the treatment of cancer. With suitable coating, these nanoparticles are biocompatible, stable in solution, and absorbed by tumor cells in good contrast. The mechanism of heating is mainly …
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Composite Nanoparticle Materials for Electromagnetics
… is the magnetic core, usually made of soft iron. Further, losses due to eddy currents and magnetic remnance occur in soft iron cores. This thesis discusses the different materials suitable that might be to replace soft iron in electromagnetic devices, Methods developed to fabricate different …
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Investigation of Metal-Dependence in DNAzymes and Applications of DNAzymes and Aptamers for Diagnostics
… labeling DNAzymes and aptamers with colored gold nanoparticles, our laboratory had previously constructed colorimetric sensors for analytes recognized by these nucleic acids. In order to make these sensors more user-friendly, dipstick tests similar to the home pregnancy test were developed using …
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Magnetic particle imaging for intraoperative breast cancer margin assessment and functional brain imaging
… uniquely images the nonlinear magnetization of superparamagnetic iron oxide nanoparticles (SPIOs). MPI boasts high sensitivity, zero background signal, positive contrast, fast temporal resolution, and quantitative detection. The field of MPI is currently preclinical, and this work aims to scale …
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Design and Development of Calcium Sensitive Contrast Agents for fMRI
… sensors for MRI based on the conjugation of superparamagnetic iron oxide nanoparticles (SPIOS) to calcium sensing protein calmodulin and its target peptides. In the presence of calcium, interaction between the two protein domains drives the aggregation of SPIOs which results in up to four …
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A Compressed Sensing Approach to Detect Immobilized Nanoparticles Using Superparamagnetic Relaxometry
<p>Superparamagnetic relaxometry (SPMR) is an emerging technology that leverages the unique properties of biologically targeted superparamagnetic iron oxide nanoparticles to detect cancer. The use of ultra-sensitive sensors enables SPMR to detect tumors ten times smaller than current imaging …
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EXPANDING APPLICATIONS OF IRON OXIDE NANOPARTICLES BY SURFACE FUCNTIONALIZATION: FROM MAGNETIC RESONANCE IMAGING TO NANO-CATALYSIS
… mainly focused on exploring the applications of superparamagnetic iron oxide nanoparticles (SPIONs) in MR imaging and nanocatalysis via surface functionalization. A dopamine-based surface-functionalization strategy was established. The Simanek dendrons (G1 to G3), oligonucleotides and amino acids …
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Preparation of multifunctional nanoparticles using microfluidics
… Lastly, encapsulation of hydrophobic superparamagnetic iron oxide nanoparticles (SPION) into LTSL was explored for their theranostic applications. Solvent compatibility of the microfluidic device was shown to be a limiting factor, which necessitated modifications of the preparation …
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ENGINEERING MAGNETIC DEVICE AND NANOPARTICLES PLATFORMS TO IMPROVE DRUG ACCUMULATION AND PENETRATION IN TUMORS FOR ENHANCED CANCER TREATMENT
… efficacy and reducing unwanted side effects. Nanoparticles have garnered significant interest as drug delivery vehicles for cancer treatment, yet they frequently suffer from physical and biological obstacles during systemic administration. These challenges include, but are not limited to, the …
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High relaxivity biomolecule based contrast agents engineered for molecular functional magnetic resonance imaging
… monoamine sensing with the disaggregation of superparamagnetic iron oxide nanoparticles (SPIOs). Ligand detection was imparted by integration of a monoamine sensing protein-based contrast agent derived from P450- BM3h (BM3). We demonstrated that this mechanism can produce robust signal changes …
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The Search for New/Unknown Signals
… be used to create positive contrast highlighting superparamagnetic iron oxide nanoparticles (SPIONs). This dissertation will show the design and optimization of iDQC anisotropy by a series of phantom experiments. A set of numerical simulations will then be provided for a sub-voxel level …
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