Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Superoxide dismutase (SOD1)"”.
-
Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
Cu, Zn Superoxide dismutase (SOD1) is an essential metalloenzyme that regulates superoxide radicals. Because SOD1 is a long-lived protein, it contains an intrinsic molecular clock, deamidation, that accumulates over time. Misfolding and aggregation of SOD1 have been linked to neurodegenerative …
-
DNA Repair, Redox Regulation and Modulation of Estrogen Receptor Alpha Mediated Transcription
… as well as the oxidative stress proteins Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and protein disulfide isomerase (PDI) are overexpressed in human breast cancer tissues. These studies provide a novel link between DNA repair, redox regulation and modulation of ERalpha-mediated …
-
A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… in oxidative stress response including Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and thioredoxin reductase (TrxR). We found that SOD1 interacts with ERalpha, enhances ERalpha-ERE complex formation, influences estrogen responsiveness and associates with estrogen responsive regions of …
-
A maternal high fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats
… such as glutathione peroxidase-1 (Gpx1), Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3) were significantly lower in the liver of HF/C pups than in C/C pups. The expression of p16INK4a, a marker of cellular senescence, and cyclooxygenase-2 (Cox2), a pro-inflammatory …
-
Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… of ALS have been linked to mutations in Cu/Zn superoxide dismutase (SOD1), resulting in mitochondrial oxidative stress and intrinsic apoptosis. Transgenic mice expressing a G93A mutant of SOD1 provide an in vivo model to investigate motor neuron death during disease progression. The principal …
-
Structure-function studies of the Parkinsonism-linked protein DJ-1
… copper cofactor for the activation of the Cu-Zn superoxide dismutase (SOD1). Using absorption spectroscopy and mass spectrometry, we found that DJ-1 binds one Cu(I) ion per DJ-1 homodimer. The structure of Cu(I)-bound DJ-1 reveals a new biscysteinate metal binding motif formed by juxtaposed …
-
Impacts of perfluorooctanoic acid on porcine oocyte health and competence
… were oocyte meiotic stage and abundances of superoxide dismutase (SOD1), apoptosis inducing factor (AIF), and BCL 2 associated X protein (BAX). We hypothesized that oxidative stress and apoptotic pathways would be affected by PFOA during the meiotic maturation period, and that co-exposure …
-
Electrostatic control of Cu, Zn superoxide dismutase aggregation in Amyotrophic Lateral Sclerosis : from lysine modification to interaction with lipid membranes.
Cu, Zn superoxide dismutase (SOD1) is a ubiquitous metalloprotein, which is responsible for protecting living cells from oxidative stress via disproportionation of superoxide ions. Misfolding and subsequent aggregation of SOD1 is casually linked to familial and sporadic cases of amyotrophic lateral …
-
Mechanisms of Ipsapirone-Mediated Neuroprotection of Ethanol-Treated Fetal Rhombencephalic Neurons: Role of Endogenous Antioxidants
… activities of endogenous antioxidants Cu/Zn-superoxide dismutase (SOD1), Mn-superoxide dismutase (SOD2), and catalase.</p><p>The results of these studies demonstrate that ethanol induces an increase in ROS and that ipsapirone pre-treatment prevents this increase. Time-course studies of the …
-
Synthesis and Characterization of Novel Polyethers and Polypeptides for Use in Biomedicine and Magnetic Resonance Imaging
… was conjugated to an antioxidant enzyme, Cu/Zn superoxide dismutase (SOD1). The conjugates were characterized and their cellular uptake was investigated.
-
Overexpression of human Cu/Zn Superoxide Dismutase in Mice; The Effect of Increase Superoxide Scavenging on Autonomic Control of the Heart.
… neural, cardiac, and endothelial tissues. Cu/Zn superoxide dismutase (SOD1) is an intracellular anti-oxidant enzyme that catalyzes dismutation of the superoxide anion (O2.-) to hydrogen peroxide (H2O2). Expression and function of this enzyme are diminished in pathologies that impair …