Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 429 for “"Superoxide"”.
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Superoxide Toxicity in Escherichia Coli
… during aerobic growth from a cellular source of superoxide. The unknown damage sensitizes the mutants to subsequent challenges with H2O2. This result indicates that there is a role for CuZnSOD other than protection from exogenous superoxide sources. The cellular source of superoxide and its …
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Superoxide stress in Escherichia coli
Since its discovery in 1969, superoxide (O2-) has been recognized as a primary source of oxidative stress. However, in the last 40 years, the only cellular target of O2- that has been identified is a subfamily of [4Fe-4S] dehydratases. The inactivation of those dehydratases can only explain part of …
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Characterization of superoxide dismutase from Actinomyces
… strain ii E1S.25D produce a Mn-containing superoxide dismutase (MnSOD). Actinomyces, once classified as yeast based on their morphology, are saprophytic organisms found among the normal flora of the mouth but can act as endogenous pathogens resulting in gingivitis and actinomycosis. The …
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Characterising the Drosophila extracellular superoxide Dismutase gene
… the key components of this machinery is the<br/>superoxide dismutase (SOD) family of enzymes which regulate ROS levels by<br/>scavenging the ROS superoxide. Mammals have three distinct SOD enzymes each<br/>responsible for managing superoxide levels in different cellular compartments. …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… in mice with a transgene (TG) for extracellular superoxide dismutase (EC-SOD) or with the EC-SOD gene knockout (KO). Adult EC-SOD mice and their wild type littermates and EC-SOD KO mice and their wild type littermates were exposed to 100% oxygen for 6 hours and for 72 hours, and the hearts were …
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Catalase, Superoxide Dismutase, and Staphylococcus Aureus Virulence
… itself against microbial attack is by producing superoxide radicals and hydrogen peroxide. These oxygen-free radicals are known to kill bacterial cells. The aim of this study was to investigate the relationship between catalase and superoxide dismutase (the enzymes that degrade hydrogen peroxide …
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In vivo metal substitution in bacteroides superoxide dismutase
… of various growth conditions on the type of superoxide dismutase (SGD) formed anaerobically in three Bacteriodes species was studied. B. fragilis, B. distasonis, and B. thetaiotaomicron were grown in ironâ restricted media with or without manganese supplementation. Iron availability was …
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Overexpression of human Cu/Zn Superoxide Dismutase in Mice; The Effect of Increase Superoxide Scavenging on Autonomic Control of the Heart.
… neural, cardiac, and endothelial tissues. Cu/Zn superoxide dismutase (SOD1) is an intracellular anti-oxidant enzyme that catalyzes dismutation of the superoxide anion (O2.-) to hydrogen peroxide (H2O2). Expression and function of this enzyme are diminished in pathologies that impair …
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Computational Evaluation of Mechanistic Pathways of Action of Superoxide Dismutase
… studies on thermodynamics of dismutation of superoxide anion radicals (O<sup>2-</sup>) to hydrogen peroxide and molecular oxygen was conducted with various theoretical models using a variety of basis sets. The computational models include semi-empirical, Hartree-Fock and density functional …
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Role of Manganese Superoxide Dismutase in Chemotherapy-induced Oxidative Stress
… lymphoma is mediated by an increase in manganese superoxide dismutase (MnSOD) protein expression and accumulation of hydrogen peroxide (H₂O₂). Findings indicate that the rapamycin-induced cytostatic effect is characterized by increased levels of MnSOD and H₂O₂, and is necessary for the full growth …
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Elucidating the contributions of superoxide dismutases to staphylococcus aureus pathogenicity
… factors of S. aureus to cause disease are superoxide dismutases (SODs). In S. aureus there are two superoxide dismutases, SodA and SodM. The loss of both SODs during a retro-orbital mouse infection led to a decrease in the ability of S. aureus to cause disease [65]. However, the individual …
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Responses of Superoxide Dismutases to Oxidative Stress in Arabidopsis thaliana
Superoxide dismutases (SODs) catalyze the dismutation of superoxide radicals to oxygen and hydrogen peroxide. Mn SOD is localized in mitochondria, Cu-Zn SOD is in the cytosol and chloroplast, and Fe SOD is in chloroplasts. The effects of a chloroplast-localized oxidative stress, caused by methyl …
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Cloning and expression of cambialistic Bacteroides fragilis superoxide dismutase gene
A gene coding for the cambialistic superoxide dismutase (SOD) was isolated from a LambdaGEM-11 genomic library of <i>Bacteroides fragilis</i>. In order to generate a complete genomic library, <i>B. fragilis</i> genomic DNA was partially digested with the restriction endonuclease Sau3AI and was …
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Superoxide Dismutase Activity During Thermal Stress and Recovery of Staphylococcus Aureus
The superoxide dismutase (SOD) activity during growth, following injury and during the recovery of Staphylococcus aureus was examined. During the growth cycle of S. aureus MF-31, the SOD activity decreased during the lag phase, paralleled a concurrent increase in cell counts during the logarithmic …
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Catalase, superoxide dismutase, and hemolysin in the virulence of Listeria monocytogenes
… monocytogenes were examined for catalase, superoxide dismutase (SOD), and listeriolysin O (LLO) activities. The two strains having the lowest catalase activities also possessed the lowest SOD activities. Exogenous hydrogen peroxide was added to suspensions of four L. monocytogenes strains; …
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Elucidating the mechanism of mitochondrial superoxide production in pro-inflammatory macrophages
… macrophages produce mitochondria derived superoxide by reverse electron transport (RET) at complex I. However, this has not been demonstrated and the mechanism of mitochondrial superoxide production is unknown. Furthermore, the influence of LPS induced metabolic reprogramming on …
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The Roles of Peroxynitrite and Superoxide in Oxidative Damage to E. Coli
… toxic biomolecule produced from the reaction of superoxide and nitric oxide (NO$\cdot)$ in the phagolysosome, may also be toxic by the same mechanism as O$\sb2{-}.$ Our in vivo results indicated that peroxynitrite has the same intracellular targets as superoxide. Of nineteen enzymes tested, only …
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