Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Superinfection"”.
-
Characterisation of HIV superinfection : genetic evolution and adaptive immune responses
… the timing and frequency of intra-subtype C superinfection, and to determine if the reason for superinfection was a greater genetic distance within epitopes of the superinfecting virus compared to those of circulating strains from the same cohort.
-
Battle of the Viruses: Aripo Virus Induced Superinfection Exclusion of Mosquito-borne Viruses
… explored as a means to eventually understanding superinfection exclusion (SIE) and utilizing it as a calculated defense against mosquito-borne disease. Aripo virus was evaluated for its SIE potential in vitro and experiments were performed to explore the possible mechanisms underlying SIE. Aripo …
-
Influenza a virus gene expression heterogeneity regulates viral superinfection potential and host innate antiviral response
… and how this heterogeneity influences viral superinfection and host innate antiviral response. To initiate productive infection, multiple SIPs must co-infect one cell to achieve complementation. Within a certain MOI range, increasing the abundance of SIPs in a viral population increases the …
-
The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… Staphylococcus aureus (MRSA) superinfection model with antibiotic therapy that resembles severe secondary bacterial pneumonia in patients that often progresses to ARDS. Despite antibiotic therapy, mice still succumb to superinfection-induced inflammatory lung damage. Using …
-
Maintaining the balance: persistent baculovirus infection in insect cells
… with a homologous baculovirus (known as superinfection) has been shown to activate the persistent infection to an overt form. In vitro studies have shown that infected cells can be resistant to superinfection although the mechanisms involved are largely unknown. In 2011, a serendipitous …
-
Within-host population dynamics and collective interactions of SARS-CoV-2 and influenza virus
… methods to characterize the role of superinfection exclusion in shaping influenza infections. As a mechanism of restricting coinfection, superinfection exclusion limits both genetic complementation and reassortment between influenza viruses, thereby restricting two major drivers of …
-
Neutralizing antibody responses in HIV dual infection: lessons for vaccine design
… conventional approaches to detect HIV co- and superinfection are confounded by recombination. Therefore, we developed an automated, Bayesian approach to detect superinfection explicitly accounting for recombination. Using simulated and real sequence data, we demonstrated that this approach is …
-
THE ROLE OF T-BET IN LUNG INFECTION
… role of T-bet, to influenza virus and bacterial superinfection was demonstrated. T-bet deficiency did not adversely affect the efficacy of viral clearance or recovery compared to wild-type hosts. Instead, elevated IL-17 production by CD8+, CD4+ and γδ T cells, as well as increased infiltration of …
-
Dissecting the Entry Pathways of Hepatitis C and Bovine Viral Diarrhea Viruses
… infected cells, specifically, the mechanisms of superinfection exclusion, the phenomenon by which previous viral infection prevents reinfection of the same cell, and the pathways of entry into target cells for these viruses. BVDV-acutely infected cells establish two blocks to superinfection, at …
-
On the Evolution of Virulence
… Lastly, we investigate the mathematics behind superinfection.</p>
-
Characterization of a Newly Identified Alphavirus, Eilat Virus
… route suggesting a narrow vector range. Lastly, superinfection experiments in an A. albopictus cell line, C7/10, demonstrated that a prior infection with EILV reduced virus replication of Sindbis, chikungunya, eastern, western and Venezuelan equine encephalitis virus by 100- to 10,000-fold …
-
Regulation of Expression of a Retroviral Transforming Gene and its Cellular Homolog
… of them susceptible to retransformation after superinfection with FSV. Type I revertants (3 clones) have lost the complete FSV provirus. Type II revertant (1 clone) has a mutated FSV provirus which encodes a transformation defective protein of MW 130,000. This protein has no kinase activity in …
-
Mixed infections of maize dwarf mosaic virus and cucumber mosaic virus in maize
… systemically infected with CMV and/or MDMV. Superinfection of protoplasts prepared from CMV infected seedlings with MDMV was not possible. As a possible vehicle for virus infection of protoplasts liposomes were produced. Initially fluorescent dyes were incorporated in them. These were fused …
-
The Role of Virus-Host Interactions in the Evolutionary Dynamics of Bacteriophage Populations
… with each other via their host, by encoding superinfection-exclusion mechanisms which, after initial infection, prevent subsequent phage from successfully infecting that host. Using stochastic simulations, I show that in the long term such mechanisms limit the adaptive potential of the phage, …
-
Characterization of Negeviruses and insect virome interactions during co-infection in cell culture
… a virus-based pathogen control strategy through superinfection exclusion. Due to its recent discovery, little is known about the biology of these ISVs or how they interact with the insect’s virome. It was recently demonstrated that both wild-type and genetically modified Negeviruses can inhibit …
-
Mechanistic interactions between Sulfolobus islandicus and its viruses
… which is chronically infected leading to a superinfection exclusion hypothesis described in Chapter 3. This hypothesis proposes that downregulation of pilA1 and pilA2 provides resistance to potentially superinfecting viruses supported by the lack of surface structures observed in …
-
The Consequences of Plant Anatomy on Viral Co-Infection
… spread through plant vasculature ‘bypasses’ superinfection exclusion (SIE), so that strains inoculated on separate primary leaves can produce populations of intermixed lesions on systemically infected leaves. This mixing phenomenon is dependent upon location and timing of primary infections. …
-
Macrolide Resistance in Mycobacterium avium
… that the resistant isolate resulted from either superinfection or selection of a resistant strain from a polyclonal population. Investigation of the mechanisms of clarithromycin and azithromycin resistance in M. avium showed that high-level resistance resulted from a point mutation at position …
-
Interferons in Influenza A Virus and Streptococcus Pneumoniae Co-Pathogenesis
… (X31) renders B6 mice extremely susceptible to superinfection compared to the resistant BALB/c mice. We found that neither the viral nor the bacterial infection alone induced IFN-γ response in both strains of mice. However, the coinfection resulted in a robust IFN-γ response in the B6 mice, not …
-
The role of resistance to varroa destructor and deformed wing virus in the European honey bee (apis mellifera)
… DWV may also offer protection to colonies via superinfection exclusion (SIE), which may be linked to Varroa-tolerant colonies. However, the role of each DWV variant in colony survivorship and mite-tolerance is limited, so the main thrust of the thesis is to address this issue. Firstly, the …
Page 1 of 2