Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Superantigen"”.
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The role of staphylococcal superantigen-like protein 7 (SSL7) in immune evasion
… with the host immune defence. Staphylococcal superantigen-like (SSL) proteins comprise a family of virulence factors suspected to target key components of the innate immune system and promote host colonisation and immune evasion. This thesis examined SSL7, a member of the SSL family previously …
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Engineering the T Cell Receptor to Protect Host Cells in Superantigen-Induced Septic Shock
Superantigens (SAgs) are potent pathogenic agents. Produced by bacteria and viruses, these proteins target a subset of white blood cells, namely T cells, which are responsible for the cell-mediated responses of the immune system. SAgs stimulate T cell populations by crosslinking a T cell receptor …
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T-Zell-unabhängige MHC-II-Signaltransduktion durch Superantigene
… In this thesis the quite unknown mechanism of superantigen-induced T cell independent MHC-II-signaltransduction is investigated. It could be demonstrated that the superantigen-induced MHC-II-signaltransduction depends on the existence of lipid rafts. Another result was the finding that the …
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Microbial interactions with epithelial surfaces.
… with the production of staphylococcal exotoxins. Superantigens are a family of staphylococcal exotoxins associated with many of these illnesses. Superantigens are defined by their abilities to induce massive cytokine release from host T cells and antigen presenting cells, leading to the …
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Charakterisierung der Eigenschaften des Mycoplasma arthritidis Superantigens
… features of the Mycoplasma arthritidis-derived superantigen (MAM) were characterized. The Mycoplasma genome exhibits a characteristically low G + C content. Apart from very few exceptions, the G + C content of Mycoplasma genomes is within the range of 24 to 33 mol%. That' s the reason why the G …
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Staphylococcal Enterotoxin B Induced Clonal Anergy in αβ T Cell Receptor Transgenic Mice
<p>Superantigens such as staphylococcal enterotoxin B (SEB) have been widely used to study T cell tolerance. While both clonal deletion and apparent anergy have been described in response to superantigens, it has not been clear whether true anergy occurs, or whether the most reactive T cells are …
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Identification of surface protein complexes of Streptococcus pyogenes through protein microarray technology
… the potent toxins secreted by GAS and known as superantigens. Several of these interactors belong to the molecular chaperone or protein folding catalyst families and presumably are involved in the secretion and folding of the superantigen. In addition, a very interesting interaction was found …
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Superantigens as vaccine delivery vehicles for the generation of cellular immune responses
… to evade their hosts. The production of superantigens is one of these mechanisms. Superantigens are potent T cell mitogens that have the unique ability to bind simultaneously to major histocompatibility complex (MHC) class II molecules and T cell receptors (TCRs). The resulting …
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The role of the adapter protein TSAd in T cell activation
… APC and transfected T cells was performed using superantigen stimulation. Using time titration, relative NF-κB translocation in T cells peaked after one hour of superantigen stimulation. Jurkat T cells in conjugates, expressing TSAd wt, showed an increase in relative NF-κB translocation with …
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The effect of subinhibitory concentrations of antibiotics on virulence factors of <i>Staphylococcus aureus</i> biofilms
… production, ability to form biofilm and the superantigen (toxic shock syndrome toxin-1 (TSST-1)) production were evaluated in challenged and control biofilms, eluates and supernatants. Moreover, since sub-MICs of antibiotics have the potential to alter virulence and interfere with metabolic …
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Characterization of a T Cell Receptor: Peptide/MHC Binding Interaction
… ligands, including monoclonal antibodies (mAb), superantigens, and peptide/MHC ligands, we have expressed a family of 2C scTCRs which contain alanine point mutations in the complementarity determining regions (CDR) and fourth hypervariable region of the $\beta$ chain. Using these mutant scTCRs, …
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On the induction of inflammatory reactions by Streptococcus pyogenes
… cells, suggesting that M1 protein functions as a superantigen. Thrombin activatable fibrinolysis inhibitor (TAFI) is a human procarboxypeptidase circulating in plasma. When activated, TAFI inhibits fibrinolysis and modulates the immune system by cleaving inflammatory mediators such as C5a, …
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Nickel-Koordinationsstellen in einem T-Zellrezeptor/Peptid/MHC-Komplex
… und Tyr94 seiner a-Kette ähnlich wie durch ein Superantigen peptidunabhängig direkt mit der HLA-DR b-Kette verknüpft. Anders als bei Superantigenen wird jedoch auch die für jeden TCR einzigartige CDR3 Region für den Kontakt verwendet. <br>Im zweiten Teil der Arbeit wurde die T913 a-Kette als …
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Die Bedeutung von Zinkionen für mononucleäre Leukocyten
… primary cells were induced to proliferate by the superantigen SPEA or were immortalised by Epstein-Barr-Virus. A similar phenomenon could be observed in vivo, since hZIP transporter expression in PBMC of patients with chronic lymphatic leukaemia was significantly decreased when compared to the …
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The Role of Lysogenic Bacteriophage in Virulence and Survival of Streptococcus Pyogenes
… regulation of a bacteriophage-encoded potential superantigen, SpeH. Next, we designed a novel system to specifically select for the loss of integrated phages entirely from the genome. This technique allowed us to study the novel role that two SF370 phage play in regulating GrAS chromosomal genes …
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Active Inhibition of T Cell Proliferation by Monocytes
… cells. In contrast, inhibition of lectin- and superantigen-mediated T cell activation may occur without activation of antigen presenting cells. It is also shown that the anti-class II mAb that inhibit OKT3-mediated T cell activation also induce tyrosine phosphorylation, metabolic activation of …
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Detection of staphylococcal enterotoxins in patients with rheumatoid arthritis or closed fracture
… haemolysin (AH), members of the pyrogenic toxin superantigen family (PTSAg). To develop a novel mass spectrometry method to analyse and compare urine samples from patients with rheumatoid arthritis (RA) and orthopaedic fracture patients for the presence of Staphylococcus aureus. Background: RA is …
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Exploring the Effects of Adjuvant Selection on a Novel Polyvalent Staphylococcus aureus Vaccine
… conserved proteins from the staphylococcal superantigen-like (SSL) family: SSL3, SSL7 and SSL11. These proteins are immune evasion factors and target different aspects of the host's immune response. The novel vaccine candidate, polySSL, was expressed as a single fusion protein, and the …
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Engineering soluble, high affinity T cell receptor domains for detection of staphylococcal and streptococcal exotoxins
… pyrogenic exotoxins (SpeA, SpeC) that possess superantigenic properties, by virtue of which they stimulate a large fraction of an individual’s T cells, leading to hyperinflammation and in some cases, organ failure and death. The molecular mechanism behind hyperinflammation has been attributed …
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A study of the contribution of mast cells to vaccination - Regulatory functions of Fc gamma receptors
… Remarkably, CTA1-DD did not function as a superantigen to activate mast cells which had captured IgE molecules with their Fc epsilon RI, indicating that CTA1-DD is safe for use in allergic patients in which mast cell Fc epsilon RI is occupied by antigen-specific IgE molecules. Furthermore, …
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