Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Super-resolution force spectroscopy"”.
-
Novel Development of Super-Resolution Force Spectroscopy and Applications in Biological Systems
… Their combination, however, has been rare. Super-resolution force spectroscopy (SURFS) was developed based on the integration of these two techniques, and it has unique biophysical applications in studying drug-DNA interactions and ribosomal translocations. I demonstrate that SURFS has a …
-
Super-Resolution Force Spectroscopy for Revealing Sub-nucleotide Motion in Ribosomal Frameshifting and DNA Methylation
… frames. This dissertation focuses on applying super-resolution force spectroscopy (SURFS) as a unique tool to resolve frameshifting products and intermediate states, with unprecedented resolution. Two different forms of forces have been studied, centrifugal force and acoustic radiation force. …
-
Single Molecule Förster Resonance Energy Transfer and Super Resolution Force Spectroscopy Study of Elongation Factor G Evolution, Conformation, and Function
… stems from the mutants becoming trapped in a ‘super’-compact conformation on the ribosome. The Thr48 mutations were modeled using AlphaFold predictions and MSAs. This revealed the mutations shifted the conformational balance to two previously reported EF-G conformations, con1 and con2. …