Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Super-enhancers"”.
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Enhancers and super-enhancers in human disease and therapy
… core promoter and at distal regulatory regions, enhancers, which are looped into close physical proximity with the core promoter. Enhancer regions are typically utilized in a cell-type-specific manner and help to drive the distinct gene expression programs that define diverse cell identities. New …
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Identification of RBPMS as a smooth muscle master splicing regulator via association of its gene with super-enhancers
… association of their genes with transcriptional super-enhancers. Using this approach, RNA Binding Protein with Multiple Splicing (RBPMS) was identified as a critical splicing regulator in vascular smooth-muscle cells (SMCs). RBPMS is strongly downregulated during SMC dedifferentiation and is …
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
… in fates. In my graduate work, I showed that super-enhancers underlie the identity, lineage commitment and plasticity of adult stem cells in vivo. My chosen model is the hair follicle, where its stem cells (HFSCs), niche and master regulators are well-characterized. By mapping global chromatin …
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Enhancers and phase separation in the control of gene expression
… of genes is regulated by DNA elements called enhancers, which are bound by transcription factors and coactivators, leading to the recruitment of RNA polymerase II and the production of RNA. Enhancers are thought to loop to specific gene promoters to stimulate transcription, but the mechanisms …
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Insights into gene regulation by genome structure, phase separation and developmental signaling
… specific gene regulatory regions called enhancers, which can be located far upstream or downstream from the gene they activate. The enhancer-bound factors can loop to the promoters of cell-type specific genes to enhance the levels of transcription of these genes, and studies described in …
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
… and/or therapeutic approaches for ccRCC. Super enhancers have been reported to drive the expression of critical transcription regulators in various biological contexts including the regulation of cancer phenotypes. Previously generated H3K27ac ChIP-Seq data from several ccRCC cell lines …
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The Role of ZMYND8 in Immunoglobulin Class Switch Recombination
… The 3' Regulatory Region (3'RR), a prototypical super-enhancer located at the 3' of the Igh locus, is essential for acceptor switch region transcription, but the mechanism by which it regulates this process is not well defined. After targeting by AID, nearby mismatches in the donor switch region …
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Characterizing the Mechanisms Regulating Enhancer Commissioning by MyoD in Muscle Cells
… transcriptional enhancer regions known as super-enhancers. Enhancer regions are opened and commissioned by master transcription factors such as MyoD. While MyoD is crucial for muscle development and differentiation due to its role in initiating muscle-specific gene expression, the …
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Genomic and microscopic dissection of large-scale chromatin compaction
… nearby enrichment of active chromatin marks, enhancers and especially super-enhancers, and cohesin and CTCF binding sites. They map closely to a large fraction of genome organization domain boundaries identified by Hi-C, LAD/innerLAD boundaries defined by lamin B1 DamID, and rapid transitions …
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Recognizing epigenetic patterns that mark the control of cell state in differentiation and disease
… of cell-type-specific gene regulators such as super-enhancers, distal-enhancer-looping, nuclear lamina, and master transcription factors. Ensembles are also disproportionately affected in both HD and Alzheimer's disease. Together, this thesis presents a toolkit for recognizing and understanding …
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Dissecting the genomic and epigenomic alterations underlying glioblastoma
… SOX2/SOX9 sites are enriched with GSC-specific super-enhancers (SEs). We identified a dual-mode of SOX2/SOX9 co-binding that was regulatory element-dependent – as a monomer at promoters and a dimer at enhancers, reminiscent of SOX9 activity in cartilage development. Co-bound SOX2/SOX9 SEs target …
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Inhibition of KDM4 with QC6352 to Target High-Risk Neuroblastoma
… factors (CRC-TFs). Driven by super-enhancers, these CRC-TFs, produce interrelated, feed-forward transcriptional loops that ultimately reinforce a specific gene expression program that defines the cellular state and identity of the cell. We showed that histone lysine demethylase …
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Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
… locus contains a region capable of binding super enhancers, exerting major influences on T cell mediated immune regulation. The enhanced cytotoxic capacity of Bach2 deficient CTL was found to be independent of changes to either signalling or degranulation but potentially the result of larger …
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Polyphosphate Modification of Human Proteins and a New Mechanism for Regulating Super-Enhancer Activity
… and uncovered polyP’s role in manipulating super-enhancer complex to regulate gene expression. Through a comprehensive screen of 57 lysine-rich human proteins, selected via mass spectrometry and bioinformatic analyses, this study identified 41 proteins that undergo denaturation-resistant …
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Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer
<p>Cell of origin studies have determined separate populations of lung progenitor cells that give rise to lung adenocarcinoma and squamous cell carcinoma. ΔNp63 is known to regulate lung development but its role in lung cancer progression remains unclear. We utilized a ΔNp63-specific conditional …