Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Super-enhancer"”.
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Polyphosphate Modification of Human Proteins and a New Mechanism for Regulating Super-Enhancer Activity
… and uncovered polyP’s role in manipulating super-enhancer complex to regulate gene expression. Through a comprehensive screen of 57 lysine-rich human proteins, selected via mass spectrometry and bioinformatic analyses, this study identified 41 proteins that undergo denaturation-resistant …
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ROLE OF A SPECIFIC NANOG SUPER-ENHANCER ERNA IN EPIGENETIC REMODELING AND ENHANCER-PROMOTER INTERACTION
During last years, the role of enhancer RNAs has been in part explored; however, it’s still not clear the exact role these transcripts carry out concerning gene regulation. In this work, the role of eRNAs transcribed from the region 5kb upper the TSS of Nanog gene in mESCs has been investigated. In …
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
… and/or therapeutic approaches for ccRCC. Super enhancers have been reported to drive the expression of critical transcription regulators in various biological contexts including the regulation of cancer phenotypes. Previously generated H3K27ac ChIP-Seq data from several ccRCC cell lines …
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The Role of ZMYND8 in Immunoglobulin Class Switch Recombination
… The 3' Regulatory Region (3'RR), a prototypical super-enhancer located at the 3' of the Igh locus, is essential for acceptor switch region transcription, but the mechanism by which it regulates this process is not well defined. After targeting by AID, nearby mismatches in the donor switch region …
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Insights into Neuroblastoma Initiation and Disease Progression Through integrative Genomics and Epigenomics
… most highly associated variant and resides in a super-enhancer defined by extensive acetylation of histone H3 lysine 27 within the first intron of LMO1. The ancestral G allele that is associated with tumor formation resides in a conserved GATA transcription factor binding motif. We show that the …
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Insights into gene regulation by genome structure, phase separation and developmental signaling
… specific gene regulatory regions called enhancers, which can be located far upstream or downstream from the gene they activate. The enhancer-bound factors can loop to the promoters of cell-type specific genes to enhance the levels of transcription of these genes, and studies described in …
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TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma
… therapy-resistant mesenchymal (MES) cell state. Super-enhancer-associated transcription factor (TF) networks define cell identities in neuroblastoma (NB). Dysregulation of these TFs contributes to the initiation and maintenance of NB by enforcing early developmental identity states. We report the …
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Dissecting The Roles of Human Smc Complexes In Transcription Regulation and Chromatin Organization
… is not a universal organizer of short-range enhancer-gene loops. We further showed that Cohesin-antagonized extra-long-distance super-enhancer loops are mediated by BRD4 phase separation, validating an emerging hypothesis that LLPS (Liquid-liquid phase separation) can drive chromatin …
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Transcriptional and structural control of cell identity genes
… gene expression through binding to enhancer elements in the genome. These enhancer-bound transcription factors regulate genes by contacting target gene promoters via the formation of DNA loops. It is becoming increasingly clear that transcription factors operate and regulate gene …
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Identifying the role of microglia in mediating ASD-relevant phenotypes in the adult brain
… regulatory element (FIRE), a highly conserved super enhancer found in the second intron of Csf1r, is also required for the development of microglia. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterised by repetitive behaviours and differences in communication. Many …
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
… in fates. In my graduate work, I showed that super-enhancers underlie the identity, lineage commitment and plasticity of adult stem cells in vivo. My chosen model is the hair follicle, where its stem cells (HFSCs), niche and master regulators are well-characterized. By mapping global chromatin …
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Microglia regulate myelin growth and integrity in the central nervous system white matter
… mouse model, in which deletion of the FIRE super-enhancer of the Csf1r gene (FIREΔ/Δ) leads to an absence of microglia, while other CNS macrophages are present. FIREΔ/Δ mice had no impairment in oligodendrocyte maturation or myelin formation in the white matter, yet showed a loss of its …