Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Sulphonamide"”.
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Investigation of ciprofloxacin antibacterial combinations.
… ciprofloxacin with trimethoprim and or a sulphonamide could prove clinically beneficial. The microbiological activity of the antibacterials used either alone or in combination was studied using in vitro techniques, against cultures of P. aeruginosa, S. aureus and Burkholderia cepacia. The …
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Organocatalytic conjugate addition reactions
… beta-unsaturated lactones and maleimides. Chiral sulphonamide catalyst proved to be an efficient catalyst for base catalyzed conjugate addition between 2(3H)-furanones and maleimides. Aromatic furanones substrates proved to be better than alkyl furanones, giving higher yields and better ees. The …
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Rhizophoraceae alkaloids : an approach to the synthesis of cassipourine
… A novel reaction, the fissioning of the sulphonamide bond by the ylid to give 2- benzyloxyethyl-p-tolylsulphone was noted in this preparation. Attempts to prepare trans-l-[l'-(p-toluenesulphonyl)-pyrrolidin- 2'-yl]-3-benzyloxy-prop-l-ene by reduction of ethyl-3-[1'-(p-toluenesulphonyl)- …
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Single-Payload Bioconjugation to Native Antibodies And A General Method for the Self-Immolative Release of Amide-Containing Molecules
… with commonly used self-immolative systems. The sulphonamide sulfamethizole was successfully released, however, the linkage proved instable preventing further exploitation of the method for sulphonamides. Urea and thioamide release was also attempted but proved synthetically challenging. The …
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Genomic diversity and antimicrobial resistance in Salmonella isolates recovered from diverse sources in Nigeria
… was poorly predicted in S. Kentucky, and more sulphonamide genes were predicted compared to phenotypic methods. Three genes conferring resistance to the β-lactams were detected, with TEM-1 β-lactamase being the most common β-lactamase found, and S. Schwarzengrund isolates with a variant of …
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Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease
… The drug classes examined were xanthines, aryl sulphonamides, quinolones, 7-methoxybenzofuran-4-carboxamides, and 7-methoxyfuro[2,3-c]pyridine-4-carboxamides. The lead molecules selected in each publication had improved PDE4:RBA ratios which translated into an improved therapeutic window in …