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Showing 1 to 14 of 14 for “"Sulfoximin"”.
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Asymmetrische Synthese und stereoselektive Substitution allylischer Sulfoximin-funktionalisierter Homoallylalkohole
… acyclic (E)- and (Z)-configured allylic sulfoximines have been synthesized from N,S-dimethyl-S-phenylsulfoximine and aldehydes via the addition-elimination-isomerization route. Titanation of lithiated (E)- and (Z)-configured allylic sulfoximines with Chlortrisdiethylanimotitan and …
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Asymmetrische Synthese funktionalisierter Homoallyl- und Homopropargylalkohole mittels der Sulfoximin-Route
… and enantiomeric pure allylic alcohols. Via the sulfoximine-route by Gais et al. new chiral homoallyllic alcohols were synthesized. Elimination of the sulfoximine-group lead to optically pure homopropargylic alcohols. Via Nickel-catalysed cross-coupling reactions (homogenoes and heterogenoes …
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Asymmetrische Synthese von allylischen Alkoholen mittels Palladium-katalysierter asymmetrischer Transformation von allylischen Carbonaten und Synthese neuer Sulfoximin-Phosphane
… this thesis is devoted to the development of new sulfoximine ligands and methods of their synthesis. On this occasion, interesting new classes of sulfoximines, alpha-(N-sulfoximido) phosphines, phosphine oxides and phosphonates, were synthesized from N-vinyl sulfoximines. These new sulfoximines …
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Synthesis of new sulfoximines for asymmetric synthesis and pseudopeptides
Sulfoximines have attracted attention due to their applicability as chiral auxiliaries, ligands in asymmetric catalysis, and building blocks in pseudopeptides. A number of approaches have been investigated for their synthesis, which allows the preparation of various derivatives in a relatively …
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Modular asymmetric synthesis of functionalized azaspirocycles based on the sulfoximine auxiliary
… was achieved in three steps from cyclic allylic sulfoximines. The first key step was a titanium-mediated gamma-hydroxyalkylation of named sulfoximines. In the course of this reaction two new stereogenic centers and a double bond were created diastereoselectively. The key step for installation of …
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Enantioselective synthesis of cyclic beta-amino alcohols via tandem hydroalumination-cyclization-reduction of ethoxycarbonyl vinyl sulfoximines and application to the synthesis of potential aggrecanase inhibitors
… alcohols starting from ethoxycarbonyl vinyl sulfoximines, which are prepared from cyclic bis(allylsulfoximine)titanium complexes and N-tert-butylsulfonyl alpha-imino ester. The application of sulfoximine substituted bicyclic 1,2-amino alcohol in the synthesis of potential aggrecanase …
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Synthese neuartiger Sulfoximine für die asymmetrische Metallkatalyse
In this work various beta-hydroxysulfoximines was synthesized. We proved their catalytic applicability in asymmetric phenyl transfer reactions onto aldehydes. Enantiomerically enriched diarylmethanols have been prepared by catalyzed asymmetric phenyl transfer reactions onto aromatic aldehydes with …
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Asymmetric synthesis of medium-sized carbocycles spirocycles and oxabicycles via ring closing metathesis sufoximine substituted trienes and dihydropyran derivates
… of medium-sized carbocycles. In this project, sulfoximine-substituted trienes were proven to be excellent parent compounds for the selective synthesis of Z-configured medium sized carbocycles. The formation of sulfoximine-substituted trienes, key intermediates of the described synthesis, was …
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Chirale Sulfonimidamide und Sulfoximine : Synthese, Strukturuntersuchungen und Anwendungen
… and the determination of the basicity of a bissulfoximine. In the first part the preparation of enantio- and diastereomerically pure sulfonimidamides bearing either an oxazolidinyl or a cyclohexylamino moiety is described, as well as the synthesis of enantiopure oxazolinyl-derivatized thioureas …
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Asymmetrische Synthese ausgehend von allylischen Sulfoximinen: neuartige Gamma-Aminosäuren und cyclische Aminosulfoxonium Ylide
… derivatives of AI-77-B. Starting from allylic sulfoximines the desired alpha-hydroxy-gamma-amino acids could be obtained with up to 34% yield over six steps. The key steps were a titanium mediated hydroxyalkylation reaction under selective construction of two stereo centers and a double bond, a …
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Neue heterocyclische Sulfoximine
… describes the synthesis of novel heterocyclic sulfoximines. Being aware the enormous application potential of heterocyclic sulfoximines (e.g. as bioactive compounds or as ligands), we were inspired to expand the existing protocols for the synthesis of this class of compounds. In the first part …
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Synthesis of chiral phosphino-sulfoximines through phospha-Michael addition and their evaluation as 1,5-P,N-Ligand in asymmetric allylic alkylation
… work describe the synthesis of new phosphino-sulfoximines and their application as 1,5-P,N-ligand in palladium-catalyzed asymmetric allylic alkylation. The key step of the synthesis of phosphino-sulfoximines is the introduction of the phosphorus via a phospha-Michael addition with …