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Showing 1 to 20 of 41 for “"Sulforaphane"”.
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Antihypertensive effects of sulforaphane
Persistent hypertension is associated with a greater incidence of organ damage and conditions such as stroke, heart failure and end–stage kidney disease, which results in increased cardiovascular (CV) morbidity and mortality. Among the patients receiving antihypertensive treatment, the level of …
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Improving sulforaphane bioavailability from cooked broccoli
… the failure of glucoraphanin (GRP) hydrolysis to sulforaphane (SF), the potent anti-cancer compound in broccoli. Certain unknown bacteria in the gut microbiota also have myrosinase-like activities that can hydrolyze GRP and release bioactive SF. However, the activity from bacteria is low compared …
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Suppression of pro-inflammatory signalling pathways by sulforaphane
… levels of pro-inflammatory cytokines. Sulforaphane (SF), an isothiocyanate obtained from broccoli, has many biological functions. The aim of this thesis was to test whether SF was able to suppress pro-inflammatory signalling using in vitro models of chronic inflammation. In human …
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Investigating the potential anti-diabetic effect of sulforaphane
… In the present study, I investigated whether sulforaphane, a natural compound derived from cruciferous vegetables, can prevent high-fat (HF) diet-induced obesity and diabetes in C57BL/6 mice. Dietary intake of sulforaphane (250 mg/kg diet) prevented hyperglycemia and increased insulin …
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
ABSTRACT Sulforaphane (SFN) is an isothiocyanate found mostly after consumption of broccoli, but also other cruciferous vegetables such as cauliflower or cabbage. Isothiocyanates have been researched for over 20 years in the field of cancer. They show many different bioactivities, of which the …
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Sulforaphane Inhibits Mammary Cancer Cell Mitotic Progression and Tubulin Polymerization
Sulforaphane (SUL), an isothiocyanate derived from hydrolysis of glucoraphanin in broccoli and other cruciferous vegetables, has been shown to induce phase II detoxification enzymes, inhibit chemically induced mammary tumors in rodents, and more recently to induce cell cycle arrest and apoptosis in …
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Modulation of the Expression of Multidrug Resistance Proteins by Sulforaphane and Erucin
Sulforaphane increases gene expression through binding of the Nrf2 transcription factor to the antioxidant response element (ARE) in the promoter region of target genes. Because SF and ER increased MRP1 expression at the mRNA level, we investigated the impact of these compounds on MRP1 …
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Regulation of Estrogen Receptor Alpha Expression in Breast Cancer Cells by Sulforaphane
Sulforaphane (SUL, 1-isothiocyanato-4-(methylsulfinyl) butane) is an isothiocyanate (ITC) derived from glucoraphanin and is abundant in broccoli and broccoli sprouts and it has a variety of potential chemopreventive actions. SUL is capable of inhibiting cancer at both early (initiation) and late …
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The bioavailability of sulforaphane from broccoli products in men and its epigenetic activity
… This benefit is attributed to the isothiocyanate sulforaphane (SF). Sulforaphane is derived from the myrosinase-catalyzed hydrolysis of glucoraphanin. Both glucoraphanin and myrosinase are present in fresh or lightly cooked broccoli and broccoli sprouts. Like myrsoinase, gut microflora are capable …
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Improving the Health Benefit of Broccoli by Maximizing Sulforaphane Formation: A Role for Epithiospecifier Protein
The isothiocyanate sulforaphane is a potent anticarcinogen derived from broccoli. For sulforaphane to be formed, fresh broccoli tissue must be crushed, allowing the myrosinase-catalyzed hydrolysis of the glucosinolate precursor, glucoraphanin. A common assumption has been that sulforaphane is the …
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The Role of Microbiota in Formation and Bioavailability of Sulforaphane From Glucoraphanin in F344 Rats
In conclusion, the cecum in the rat is the major site of fermentation by microbiota. Since the colon is right next to the cecum, colonic NQO1 induction as well as cecal inflammation indicate that cecal microbiota may play an important role in the hydrolysis to bioactive SF from GRP. However, the …
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Sulforaphane as a potential nutritional intervention to reduce neuroinflammation associated with aging and sickness behavior
… Dietary broccoli and its derived bioactive sulforaphane (SFN) has potential use as a novel nutritional intervention to reduce aging-related neuroinflammation. Sulforaphane activates nuclear factor E2-related factor 2 (Nrf2), which induces antioxidant response element genes that regulate …
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Sulforaphane sensitizes TRAIL-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated upregulation of DR5
"Sulforaphane (SFN) is a chemopreventive agent present in various cruciferous vegetables, including broccoli. Here, we show that treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in combination with subtoxic doses of SFN significantly induces rapid apoptosis in …
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ANALYSIS OF ELECTROPHILE-INDUCED NRF2 GENE ACTIVATION
… to Nrf2 activation.The chemopreventive agent sulforaphane is an isothiocyanate, which was isolated from broccoli. Sulforaphane was demonstrated to induce ARE-regulated genes by stimulating the Keap1-Nrf2 system. This agent is a powerful electrophile that can react with thiols to form …
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Assessing Hepatic Gene Expression in Response to Xenobiotic Exposure in Mice
… associated with fescue toxicosis, and sulforaphane, a phase II inducer. Hypothesized responses in liver gene expression and enzyme activity due to exposure to these xenobiotics were tested. Polymorphic mice were gavaged with sulforaphane, ergotamine or control over four daily dosing …
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The Metabolic Fate of Glucoraphanin in F344 Rats
… dietary source of the potent isothiocyanate, sulforaphane (SF). Sulforaphane has been shown to have multiple mechanisms to fight cancer. However, sulforaphane is present in broccoli as its precursor, glucoraphanin (GP). Previous studies have reported that humans do not have the enzyme to …
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Investigating Potential Therapies to Decrease the Rate of Cystine Stone Growth in Slc3a1-/- Mice
… mouse model. Six pharmacological interventions – sulforaphane, methyl selenocysteine, homocysteine, tiopronin, TPEN and a zinc-supplemented diet– were also examined for their efficacy in reducing the rate of cystine stone growth. µCT analysis revealed stone growth proceeds linearly. Sulforaphane …
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Enhancing human health promoting activity through the regulation of the methyl jasmonate mediated glucosinolate biosynthesis in Brassica oleracea
… of two years under field conditions (Chapter 3). Sulforaphane, phenethyl isothiocyanate, and hydrolysis products derived from neoglucobrassicin were significantly increased by MeJA treatment. Sulforaphane, N-methoxyindole-3-carbinol (NI3C), and neoascorbigen showed significant correlations with QR …
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