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Showing 1 to 20 of 74 for “"Sulfonamide"”.
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Herbicide Mediated Selection of Sulfonamide Resistant E. coli
… an herbicide that is structurally analogous to sulfonamide antibiotics (sulfas), with the potential to contribute to the global antibiotic resistance crisis by cross-selecting for sulfa-resistant bacteria. To determine if asulam can select for antibiotic resistant bacteria, isothermal titration …
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Transport and fate of veterinary sulfonamide antibiotics in soil
Sulfonamide antibiotics is one group of important pharmaceuticals in the veterinary medicine market. Discharge of antibiotics from wastewater treatment plants lead to their presence in river and groundwater. In agricultural regions, application of animal manure on crop lands is a major …
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Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs
Pseudopolymorphs of two sulfonamide drugs, namely sulfathiazole and succinylsulfathiazole, have been prepared by recrystallization of the drugs from various organic solvents and their properties have been studied by several physicochemical methods. Thermal Analysis involving Thermal Gravimetry (TG) …
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Properties of the Merozygotes Associated with a Sulfonamide-Resistant Mutation in Pneumococcus
<p>Unstable prokaryotic strains arise occasionally under a variety of circumstances and with a variety of properties which make them amenable to genetic and physiological analysis at different levels of precision. A review of a number of such unstable systems, initially identified on the basis of a …
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Removals of sulfonamide and trimethoprim antibiotics in municipal wastewater by biological treatment processes
… was developed for the analysis of six sulfonamide antibiotics (sulfadiazine, sulfamerazine, sulfamethazine, sulfamethoxazole, sulfapyridine and sulfathiazole), two sulfonamide metabolites (N4-acetyl sulfamethazine and N4-acetyl sulfamethoxazole) and the commonly co-applied antibiotic …
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Synthesis of Novel Sulfonamide-Based Calpain Inhibitors and Their Potential as Anti-Tumor Agents
… screened by virtual screening method and diazosulfonamide <strong>1 </strong>(<em>K</em>i = 1.0 ± 0.02 µM) was identified as a new nonpeptide competitive inhibitor of µ-calpain. Analogues of <strong>1 </strong>were synthesized to explore structure requirements of <strong>1 </strong>(Chapter 2). …
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Derivatization of porphyrins for DNA and metal ion binding, especially by employing secondary sulfonamide links
… or tertiary (SO<sub>2</sub>NR<sub>2</sub>) sulfonamide group. The sulfonamide group was found to be a versatile way of expanding the porphyrin. The presence of a tertiary sulfonamide group instead of a dissociable proton improved the solubility of the new class of porphyrin compounds …
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Exploring the binding of amine and sulfonamide ligands in Rhenium(I) Tricarbonyl and Platinum(II) complexes
… ligands bearing a dansyl moiety linked by a sulfonamide group were prepared; in some cases the sulfonamide nitrogen formed a bond to Pt. The sulfonamido group donates strongly to Pt and places the dansyl group close to a vacant coordination position, allowing it to stack with bound guanine …
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The crystal landscape and cocrystallization of primary aromatic sulfonamides
This thesis is focused on primary benzenesulfonamides. They have been structurally characterised and analysed for common structural motifs present in the solid state. A systematic investigation of their cocrystallization with a range of neutral, zwitterionic and ionic coformers has been carried, …
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Determination of chlorine by fluorescence quenching
… This study focuses on development of a sulfonamide-based collection system for low levels of chlorine in air. Quantitation of chlorine is based on the quenching of the fluorescence signal observed when chlorine reacts with the fluorescent sulfonamide compound. Both a direct fluorimetric …
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Collection of gas phase chlorine using bonded silica sorbents
Sulfonamide functionalities bound to silica substrates have been investigated for collection of gas phase chlorine. Sorbents were prepared by bonding aminopropyl groups to a substrate (silica gel or filters) and then reacting with alkyl or aryl substituted sulfonyl chloride to produce the …
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The Design, Synthesis, and Investigation into Small Molecule Modulators of the Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (SHIP)
… as well as studies into a newly discovered sulfonamide-based SHIP1 selective agonist. Attempts to modulate SHIP activity by means of small molecules led us to develop and synthesize various small molecule tryptamine inhibitors in hopes of increasing the selectivity and potency, as well as …
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Synthesis and Characterisation of Dual CCR7/CXCR4 Antagonists
… Our group has previously identified a series of sulfonamides as CCR7 antagonists. This project aims to extend on those studies and to develop a dual CCR7 and CXCR4 antagonist to reduce metastasis in cancer. Novel potent biaryl sulfonamide CCR7 antagonists were synthesised and assessed by calcium …
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Polymer-supported reagents for disinfection of water
… resin having redox N,N-dichlorosulfonamide group, was modified for use in small-scale chlorination of potable water. The resin was synthesized via sulfonyl chloride by modification of the strong acid cation exchange resin, Amberlyst-15. The products obtained after treatment …
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Fundamental studies on 2,4,6-trichlorophenyl sulfonate esters
… esters in the synthesis of sulfonamides. The sulfonamide unit is an important structural motif due to its frequent occurrence in a range of pharmaceuticals, particularly antibiotics. Sulfonamides can be readily synthesised from pentafluorophenyl (PFP) sulfonate esters and as …
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Crystallographic studies of carbonic anhydrase isoforms and their complexes with inhibitors /
… of several CA isoforms with a series of sulfonamide inhibitors using X-ray crystallography technique, 2) to analyze the interactions between the ligands and the CA proteins, determine the mechanisms of binding selectivity, affinity, and 3) search for the correlations between the structure …
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Experimental and Computational Studies on Copper and Hydrobenzoin Derivatives in Catalytic Asymmetric Reactions
… and a [alpha]-methyl-[gamma]-alkenyl sulfonamide substrate. The results suggest the N-C bond formation proceeds via a cisaminocupration, and not through a radical-type mechanism. Additionally, the origin of diastereoselection observed with [alpha]-methyl-[gamma]-alkenyl sulfonamide …
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DESIGN AND SYNTHESIS OF ALPHA-AMINO ACID AND MORPHOLINO `CHIMERA' BUILDING-BLOCKS
… to the transposition of both cyclic tertiary sulfonamide esters2 (i.e. proline derivatives) and open chain secondary compounds.3 These latter, in the first step, are N-alkylated and then rearrange to the target products. This protocol has also been applied to the degradative rearrangement of a …
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