Global ETD Search
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Showing 1 to 4 of 4 for “"Sulfinamide"”.
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Developing Detection Methods for Nitroxyl
… GSH reacts with HNO to produce glutathione sulfinamide (GS(O)NH₂), which is a selective biomarker of HNO. We developed an in vivo assay that indirectly detects HNO by quantifying the production of GS(O)NH₂. The free amine on GS(O)NH₂ was fluorescently labeled with NDA, and capillary zone …
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Preparation of N,N'-Dialkyl bis(diamino) diphenylmethanes and N,N'-Dialkyl bis(diamino) benzophenones: preparation of B-hydroxy sulfonamides and B-hydroxy sulfinamides
… yield. The attempted preparation of β-hydroxy sulfinamides involved initially the synthesis of N-methanesulfin-p-toluidide following the procedure of Corey and Durst. This compound was subsequently alkylated with sodium hydride and methyl iodide in 1.2-dimethoxyethane in 76% yield. Treatment of …
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Method development for the comprehensive analysis of post translational modifications by mass spectometry
… HNO-induced modifications, fragmentation of the sulfinamide- and sulfinic acid-modified peptides produced a neutral fragment of 65 Da and 66 Da, respectively. With respect to the second issue, a multiplexed technique for monitoring modifications that fragment as neutral losses, termed Multiple …
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Understanding the crystal landscape of primary sulfinamides and predicting cocrystallization
… in the synthesis of a library of primary aryl sulfinamides, an under-studied sulfur functional group from a solid state chemistry perspective. Their solid-state properties are examined, with focus on the robust supramolecular synthons that they exhibit. Finally, this chapter describes their …