Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Sulfatide"”.
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The Role of Sulfatide in Alzheimer's Disease
… to membrane domains called lipid rafts. Sulfatide (ST) is a glycosphingolipid that is essential for the proper structure and function of lipid rafts. In mice that lack ST, membrane domains that are normally maintained by adhesive contacts and functional lipid rafts are improperly formed …
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Structural basis for sulfatide recognition by Disabled-2
… In platelets, Dab2 associates with membrane sulfatide at the platelet surface, modulating platelet inside-out and outside-in signaling pathways. A Dab2-derived peptide, named the sulfatide-binding peptide (SBP), is the minimal unit of Dab2 to exert its function as a negative regulator of …
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Disabled-2 regulates platelet heterotypic and homotypic aggregation through sulfatide binding
… interactions. Dab2 is also capable of binding to sulfatides, through the N-PTB region, expressed on the outer leaflet of adjacent cells. Dab2-sulfatide binding decreases Dab2's ability to interact with the αIIbβ3 integrin, however sulfatides activate and stimulate platelet-platelet and …
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The Role of Sulfatide in the Development and Maintenance of the Nodal and Paranodal Domains in the Peripheral Nervous System
Sulfatide is a galactolipid and a major lipid component of the myelin sheath. Its production is catalyzed by the enzyme cerebroside sulfotransferase (CST). To determine the functions of sulfatide, the gene encoding CST was genetically disrupted resulting in mice incapable of sulfatide synthesis. …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… The first part of this thesis, I showed that sulfatide, a major lipid component of myelin sheath, participates in diverse cellular events of the CNS. Sulfatide changed the morphology of primary microglia to their activated form, and it significantly induced the production of various …
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Molecular characterization of soybean meal trypsin inhibitors and lectins as a basis for developing approaches to mitigate their anti-nutritional effects
… could be also targeting another ligand called sulfatide besides GalNAc in the small intestine due to some similarities between soybean lectin and galectin-4, a mammalian lectin that binds to sulfatide in the small intestine. Hence, we also explored soybean lectin to sulfatide interactions to …
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HIV-Associated Neurocognitive Disorders: Role of Viral Reservoirs and Lipid Dysregulation
… several myelin components, including the lipid sulfatide. Soluble sulfatide compromises gap junctional communication and calcium waves, which contribute to the amplification of CNS damage and cognitive impairment that distress the HIV-infected population. Our pending experiments aim to …
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Sulfatides mediate Disabled-2 membrane localization and stability during platelet aggregation
… binding on the activated platelet surface.3 Sulfatides are also found on the platelet surface,4 interacting with adhesive and coagulation proteins5-7 and, thus, they are thought to play a major role in haemostasis and thrombogenesis. Here, we show that the Dab2 PTB domain specifically …
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Membrane binding properties of Disabled-2
… within the PTB domain. Alternatively, Dab2 binds sulfatides on the platelets surface, and this binding partition Dab2 in two pools (sulfatide and integrin receptor-bound states), but the biological consequences of lipid binding remain unclear. Dab2 binds sulfatides through two basic motifs located …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
… lipids, including galactosylceramide and sulfatide, and a generally low amount of gangliosides in both sub-populations, irrespective of confluence. Then, we studied the sphingolipid turnover in more detail using a metabolic labeling approach. Our results showed that BV-2 cells are …