Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Sulfasalazine"”.
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Can curcuminoids be more effective than sulfasalazine for the treatment of rheumatoid arthritis?
… Current treatment includes methotrexate and sulfasalazine, however, side effects and tolerability are major limitations. Curcumin is a natural polyphenol obtained from Curcuma Longa (turmeric) that exhibits potent anti-rheumatic properties. In this study, column chromatography and preparative …
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Genetic factors that determine host resistance to bacterial infection
… enterica serovar typhimurium with the drug sulfasalazine. This drug is a known inhibitor of SLC7A11.From the results it can be seen that inhibition of SLC7A11 may cause a trend towards beneficial effects in stopping the infection of macrophages by Salmonella enterica serovar typhimurium. …
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Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation
… common drugs via supramolecular derivatization. Sulfasalazine is a powerful anti-inflammatory drug and fluconazole has a strong antibacterial and antifungal activity. The common feature is their very low solubility in water. Cyclodextrin inclusion complexation and co-crystallization were carried …
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Studies on Taxol Resistance Induced by HBx Viral Oncoprotein
… cell death pathways. In addition, we found sulfasalazine, inhibitor of NF-κB activation, significantly increased cell death in ChangX-31 and ChangX-34 in a caspase-dependent manner but had not in fluence on Chang cells. Therefore, we conclude that HBx play an important role in …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… efficacy of two different SLC7A11 inhibitors, sulfasalazine and erastin. Sulfasalazine proved ineffective at reducing orthotopic pancreatic tumour growth, indicating it cannot be repurposed as PC therapy. Excitingly, erastin showed significant anti-proliferative effects in both PC cells and …
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Effect of Estradiol on xc- in Human Breast Cancer Cells
… defense against oxidative stress. The drug sulfasalazine (SASP) has been shown to specifically inhibit this system leading to cell stasis and glutathione depletion. Using the ER positive human breast cancer cell line MCF-7, the xc- specific subunit, xCT, mRNA and protein expression were …
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Identifying novel therapeutic targets for seizures and brain cancers
… exchange transporter (XCT) antagonist sulfasalazine reduced the frequency of seizures. In human studies of TAS, increased levels of glutamate, reduced excitatory amino acid transporter 2 (EAAT2) expression and reduced XCT were associated with greater frequency of TAS. We found that …
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GLIOBASTOMA MULTIFORME UTILIZES SYSTEM Xc¯ FOR SURVIVAL UNDER OXIDATIVE STRESS AND PROMOTES CHEMORESISTANCE
… cell survival and reduce tumor progression. Sulfasalazine is an FDA approved drug in the treatment of arthritis and Crohne’s disease and has been shown to inhibit system Xc<sup>–</sup>. <em>In vitro </em>SASP<em> </em>studies demonstrated a strong antitumor potential in preclinical mouse …
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Modulating System xc- Activity As A Treatment For Epilepsy
… studies also found that SXC inhibition with sulfasalazine (SAS), an FDA approved drug and potent inhibitor of SXC, can ameliorate seizure burden in a glioblastoma mouse model. Therefore, the principal objective of this study is to further investigate the role of astrocytic SXC activity in …
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Inhibition of cellular glutamate efflux as a novel strategy to curb canine hemangiosarcoma proliferation and survival
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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CHCHD2 and the tumor microenvironment in glioblastoma
… KO cells displayed increased sensitivity to sulfasalazine, erlotinib, and temozolomide, but not the procaspase activator Pac-1. CHCHD2 exhibited a heterogeneous protein expression pattern among patient-derived cells investigated using western blot, with greater levels observed in more …
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Role of the IKKβ/NF-κB pathway in alcoholism
Pro-inflammatory neuroimmune signaling pathways are implicated in the acute and chronic effects of alcohol exposure. Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, transcriptome meta-analysis in rodents, and drinking models in mice …