Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Suicide inhibitor"”.
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Targeting Mitochondrial Proline Dehydrogenase (PRODH) with a Suicide Inhibitor as a Novel Anticancer Strategy
… acid, 5-oxo) and irreversible/suicide (PPG) inhibitors of PRODH using cultured human breast cancer cells. PRODH knockdown or enzymatic inhibition each inhibited cell growth and induced variable degrees of apoptosis against malignant breast epithelial cell lines (ZR-75-1, DU4475, …
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Synthesis of cis- and trans-3-fluoroacrylate, and inhibition of BCL6 targeting a non-reactive cysteine
… for two substrates for one project and an inhibitor in a second project. In the first project, synthetic routes were devised to make the cis- and trans-isomers of 3-flouroacrylate. In both cases, the compounds were successfully made in a four-step procedure. In future work, the compounds …
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Structural and biophysical analysis of the proteasomal deubiquitinase, UCH37
… with ubiquitin vinyl methyl ester (UbVME), a suicide inhibitor substrate. Our structure, in combination with another solved of a longer construct of TsUCH37 in complex with UbVME, provided structural insights into the ability of UCH37 to process polyubiquitin, namely that its C-terminal …
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Development Of Novel Breast Cancer Chemotherapeutics Directed Towards The Attenuation Of Metastatic And Chemo-Resistant Breast Cancer
… and migration, (iPLA2β and MMP-9), with a suicide inhibitor Bromoenol Lactone (BEL). Although this approach did result in significant attenuation of tumor growth and migration, it lacked the ability to be highly selective and the therapeutic index left something to be desired. With that in …