Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Sudden unexpected death in epilepsy"”.
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Investigating Central Chemoreception-based Biomarkers of Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden Unexpected Death in Epilepsy (SUDEP) causes significant mortality in epilepsy, affecting 1:1000 people every year. Preceding SUDEP, patients experienced a final GTC seizure, transient apneas and bradycardia, culminating in terminal apnea and asystole. Failure to recover from postictal …
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NEUROACTIVE AGENTS-MEDIATED CHANGES IN NEURONAL NETWORK ACTIVITY CONTROLS SUSCEPTIBILITY TO SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP)
The incidence of sudden death is higher in epileptic people compared to the general population and sudden unexpected death in epilepsy (SUDEP) is second only to stroke in the years of potential life loss among the major neurological disorders. In the majority of observed human SUDEP cases, …
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Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
Approximately 1:26 people have epilepsy and around 30% of those cannot effectively treat their seizures with medications, putting them at risk for Sudden Unexpected Death in Epilepsy (SUDEP). We recently demonstrated the progressive nature of epilepsy and mortality in Kv1.1 knockout (KO) mice, a …
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Optimizing the neural response to electrical stimulation and exploring new applications of neurostimulation
<p>Electrical stimulation has been successful in treating patients who suffer from neurologic and neuropsychiatric disorders that are resistant to standard treatments. For deep brain stimulation (DBS), its official approved use has been limited to mainly motor disorders, such as Parkinson's disease …
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Investigation of Tanycytes and Orexin Neurons in the KCNA1-Null Mouse Model of Epilepsy
… of two projects. The Kcna1-null mouse model of epilepsy was used in both projects. Project I: Spontaneous Recurrent Seizures (SRS), a hallmark of epilepsy, disturb brain homeostasis due to abnormal metabolism, increased neuronal excitability, and ectopic neurogenesis. Tanycytes are specialized …
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Continuous assessment of epileptic seizures with wrist-worn biosensors
Epilepsy is a neurological disorder characterized predominantly by an enduring predisposition to generate epileptic seizures. The apprehension about injury, or even death, resulting from a seizure often overshadows the lives of those unable to achieve complete seizure control. Moreover, the risk of …