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Showing 1 to 6 of 6 for “"Sucnr1"”.

  1. Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation

    Krzak, GrzegorzUniversity of Cambridge2023

    … succinate signalling via succinate receptor 1 (SUCNR1) plays a key role in controlling myeloid cells responses in systemic inflammatory conditions. However, how the succinate-SUCNR1 axis regulates myeloid cell functions in the central nervous system (CNS) inflammatory disorders, such as multiple …

    cambridge Repository record

  2. Synthèse et évaluation pharmacologique de modulateurs du récepteur de l'acide succinique (SUCNR1).

    Gilissen, JulieULiège - Université de Liège2011

    liege Repository record

  3. Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation

    Peruzzotti-Jametti, LucaUniversity of Cambridge2018

    … MPs, which activates succinate receptor 1 (SUCNR1)/GPR91 on NSCs, thus initiating prostaglandin E2 secretion and extracellular succinate scavenging. This work uncovers a succinate-SUCNR1 axis in NSCs that clarifies how stem cells respond to inflammatory metabolic signals to inhibit the …

    cambridge Repository record

  4. Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling

    Tong, Wenxin2022

    … ligands for previously orphan receptors GPR91 (Sucnr1) and GPR99 (Oxgr1), respectively. The function of Sucnr1 is more extensively studied and its activation by succinate regulates pleiotropic biological processes. The physiological range of circulating succinate coincides with the …

    duke Repository record

  5. Novel Agonists and Antagonists of Platelet Receptors

    Högberg, CarlDepartment of Cardiology, Clinical sciences, Lund University2011

    … clopidogrel had no effect. The succinate GPCR (SUCNR1) mRNA has been found at high levels in platelets. We performed a study on SUCNR1 to investigate its function in platelets. The study showed that the succinate receptor was expressed as a membrane bound Gαi-protein. Succinate per se could …

    lund Repository record

  6. Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy

    VICARIO, NUNZIOUniversità degli studi di Catania2017

    … to ameliorate neuroinflammation via succinate-SUCNR1-dependend mechanisms. To characterize the potential for tissue replacement and remyelination of such a promising cell line, I have also analysed how iNSCs grafts differentiate in an experimental model of focal demyelination. I found that …

    catania Repository record