Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Succinate dehydrogenase"”.
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Management of Root-knot Nematodes in North Carolina and Sensitivity of Watermelon Pathogens to Succinate Dehydrogenase Inhibitors.
North Carolina State University Theses Plant Pathology.
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A study of succinate dehydrogenase deficient tumourigenesis: From functional assessment of variant pathogenicity to the discovery of new disease biomarkers
… function of the citric acid cycle enzyme complex succinate dehydrogenase (SDH) is associated with a predisposition to a spectrum of tumourigenesis including phaeochromocytoma, paraganglioma (1) (PPGL), gastrointestinal stromal tumours (GIST) (2), renal cell carcinoma (RCC) (3) and pituitary …
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Estudo citoquímico de enzimas mitocondriais de Trypanosoma cruzi em culturas de tecido
… as hidrogen aceptors of the reaction to locace Succinate Dehydrogenase (E.C. 1.3.99.1), Isocitrate Dehydrogenase (E.C. 1.1.42), a Glycerophosphate Dehydrogenase (E.C. 1.1.2.1), b Hydroxybutyrate Dehydrogenase (E.C. 1.1.1.30) and NADPH Tetrazolium Redutase. Light microscopy showed an intense …
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Molecular Studies of the Succinate:ubiquinone Oxidoreductase of Escherichia Coli
Succinate:ubiquinone oxidoreductase (Complex II) is a membrane-bound enzyme present in aerobically grown bacteria and in the mitochondria of eukaryotes. It functions as succinate dehydrogenase in the citric acid cycle and transfers reducing equivalents to ubiquinone in the aerobic electron …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… a potential therapeutic vulnerability. Moreover, succinate dehydrogenase activity appears impaired, further exacerbating mitochondrial dysfunction. Collectively, this work uncovers a previously unrecognized role of BACE2 in sustaining metabolic flexibility in metastatic melanoma, positioning it as …
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The Effect of Post-Injury Exercise Training on Skeletal Muscle Mitochondria
… treadmill running. Fibre type-specific SDH (succinate dehydrogenase) content of type I, IIa, IIx and IIa/IIx fibres was compared between activity groups (sedentary vs exercise trained) at 14 and 50 days post-cardiotoxin-induced injury. Interestingly, 14 days of endurance exercise after an …
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Skeletal muscle morphology and function in former elite distance runners : a 20 year follow-up
… continued high volume, high intensity running, succinate dehydrogenase (SDH) activity and type I and type II muscle fiber areas were similar between evaluations. In 1993, the HI group had higher (p<0.05) SDH and citrate synthase (CS) activities compared with the FIT and UT groups, whereas …
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The Proteomic Response of Gill Tissue in Tidally and Subtidally-Acclimated California Mussels, Mytilus californianus, to Acute Emersion-Induced Anoxia
… acid cycle enzymes (e.g. aconitase, succinate dehydrogenase) suggest that tidally-acclimated mussels are also primed to sense reactive oxygen species (ROS) and limit their production, respectively. These findings are further supported by higher abundances of several aldehyde …
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Understanding patient engagement: exploring factors around utilisation of screening and surveillance services in individuals with or at risk of rare endocrine syndromes
… Endocrine Neoplasia and mutations in the succinate dehydrogenase complex genes can develop diverse and unpredictable new tumour formations. Regular screening is recommended as best practice for early detection and management of tumours in those deemed at risk. However, little is known …
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"Interrogating the genomic and metabolomic landscape of pseudohypoxic phaeochromocytoma and paraganglioma syndromes"
… of PPGLs have highlighted that tumours with succinate dehydrogenase deficiency (SDHx) are among the most frequently mutated group of susceptibility genes. Identifying individuals carrying a pathogenic variant in one of these genes leads to lifelong surveillance. Despite the low tumour …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… MK, PTN, and endogenous housekeeping gene as Succinate dehydrogenase complex subunit A (SDHA). FGF2 and SDHA mRNA expression was significantly different using Mann-Whitney U test. An in vitro villous trophoblast invasion model was performed with human fibrosarcoma HT1080 invasive cells …
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
… to IR injury, and the respiratory complex succinate dehydrogenase (SDH) has been identified as a new therapeutic target. The mitochondrial metabolite succinate accumulates during ischaemia, before being rapidly oxidised by SDH upon reperfusion, producing reactive oxygen species (ROS), and …
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Developing drugs to attenuate succinate accumulation and oxidation
… Mitochondria are at the heart of IR injury, with succinate dehydrogenase (SDH) a major player in orchestrating the damage. Succinate accumulates during ischaemia and is rapidly oxidised by SDH upon reperfusion, producing reactive oxygen species (ROS), leading to cellular death. I have investigated …
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Elucidating Functional Roles For Myogenin In Adult Skeletal Muscle Metabolism, Exercise Capacity, and Regeneration
… muscle fibers, and displayed increased levels of succinate dehydrogenase activity, indicative of increased oxidative metabolism. Mdx:Myog-deleted mice exhibited a similar phenotype, outperforming their mdx counterparts, although lagging behind wild-type animals. The morphology of muscle tissue …
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Computational Modeling and Analysis of Protein Interactions at Multiple Coarse-grained Levels in Biological Systems
… of high-order clusters in the protein complex Succinate Dehydrogenase (SDH). Our findings show crowding stabilizes clusters not present in dilute conditions and the spatial arrange- ments of the subunits vary with cell types. We also explore protein interactions in gene regulatory networks. …
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IDENTIFICATION AND CHARACTERIZATIONS OF PATHOGENICITY GENES IN FUSARIUM VIRGULIFORME, THE CAUSAL AGENT OF SOYBEAN SUDDEN DEATH SYNDROME (SDS)
… was to investigate the efficacy of ILeVO®, a succinate dehydrogenase inhibitor fungicide from Bayer CropScience, against F. virguliforme. Our results showed that ILeVO® was very active against F. virguliforme in vitro and was very effective in minimizing F. virguliforme infection thus …
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Metabolic engineering of microorganisms for the overproduction of fatty acids
… the interruption of TCA cycle such as removal of succinate dehydrogenase as the most prioritized genetic intervention to further improve fatty acid production. Meanwhilem, the whole genome transcriptional analysis revealed acid stress response, membrane disruption, colanic acid and biofilm …
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Targeting Mitochondrial ROS Production in Kidney Transplantation
… mitochondria, including the respiratory complex succinate dehydrogenase (SDH). The aim of this thesis was to determine whether malonate ester prodrugs, which competitively inhibit SDH, may reduce mitochondrial ROS production and ameliorate IRI in models of kidney transplantation. Herein, I show …
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Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… the tricarboxylate acid (TCA) cycle intermediate succinate during ischaemia and its rapid oxidation during reperfusion by succinate dehydrogenase (SDH). This drives reverse electron transport (RET) via complex I of the mitochondria to generate harmful reactive oxygen species (ROS) in a process …
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Metabolic engineering and modelling of Escherichia coli for the production of succinate
… sustain a green chemical industry in the future. Succinate is one of those biochemicals. Today, this compound is synthesised via maleic anhydride, which is produced by a petrochemical production process. The conditions which a biological production processes have to meet to be economically viable …
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