Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Subthalamic nucleus"”.
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Role of the Subthalamic Nucleus in the Circuitry Mediating Food- and Cocaine-Seeking Behavior
The subthalamic nucleus (STN) is part of the basal ganglia, which play a crucial role in motor control and in processing information from motor cortical areas. Although the STN is classically considered a motor structure, recent studies suggest that it may also be involved in the motivation for …
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Effect of dopamine on synchronous neuronal oscillations in the globus pallidus-subthalamic nucleus network
… Parkinson’s disease. The globus pallidus (GP) – subthalamic nucleus (STN) network has been proposed to form a pacemaker driving regenerative synchronous bursting activity. In order to test whether this activity can be sustained in vitro a 20o parasagittal slice of mouse midbrain was developed …
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Trajectory of Quality of Life in Advanced Parkinson's Patients Receiving Bilateral Subthalamic Nucleus Deep Brain Stimulation
<p>Quality of Life (QOL) in Parkinson's disease (PD) patients after Deep Brain Stimulation (DBS) neurosurgery generally improves between 3 to 24 months post-operatively. However, QOL beyond 2 year follow-up is generally unknown. This study examined the QOL in 16 advanced PD patients who received …
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Adaptive Detection of Beta Bursts of Local Field Potentials Recorded from Subthalamic Nucleus in Patients with Parkinson’s Disease
… leads placed into the motor territory of the subthalamic nucleus (STN) can be used to investigate the mechanism of PD and allows for further development of new therapeutic strategies. Beta band activity, which typically presents itself as bursts, has been continuously found in the LFP …
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Simultaneous Behavior Onset Detection and Task Classification for Patients with Parkinson Disease Using Subthalamic Nucleus Local Field Potentials
… on recorded Local Field Potentials (LFP) of the Subthalamic nucleus (STN), captured through Deep Brain Stimulation (DBS) process.</p> <p>One main part of this work is dedicated to the research of various properties and features of the STN LFP signals of several patients' behavior conditions. …
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Characterization of the Zona Incerta
… which is the structure directly above the Subthalamic Nucleus, a target nucleus. Characterization of the firing frequency of the Zona Incerta will help aid Deep Brain Stimulation procedures. Looking at the Interspike Intervals for 25 files showed that the average firing frequency is 11.6Hz. …
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The Effects of Deep Brain Stimulation on the Speech of Patients with Parkinson's Disease
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has received more attention in recent years as a treatment option for regulating the symptoms of Parkinson's disease. Previous studies of DBS documented consistent improvements in motor function but more variability in speech outcomes. …
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"Towards Closed-Loop Sleep Monitoring in Parkinson’s Disease: Self-Supervised Learning Strategies for Sleep Stage Classification"
… real-time sleep-stage classification from subthalamic nucleus signals, a task where conventional models generalize poorly. To address pronounced class imbalance and improve cross-patient generalization, this work introduces a self-supervised transformer framework. The model employs a masked …
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Understanding Autonomic Control via Human Deep Brain Stimulation
… field potentials (LFPs)) to assess whether a nucleus is integral to a specific change in autonomic output. The sum of my work outlined in this thesis demonstrates that common DBS targets such as subthalamic nucleus (STN) and pedunculopontine nucleus (PPN) alter both cardiovascular and …
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Quantitative assessment of human gait patterns using biomechanical and dynamical tools
… of aging, PD, and the use of implanted bilateral subthalamic nucleus deep brain stimulation on persons with severe PD symptoms. Biomechanical analysis using kinetic and kinematic metrics were also performed to investigate the effects of novel equipment design on level walking and obstacle crossing …
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Expectation, the placebo effect and Parkinson's disease : an investigation using high-resolution positron emission tomography
… study conducted in patients who had undergone subthalamic nucleus deep-brain stimulation (STN-DBS) in which we examined how awareness of stimulator status (ON or OFF) affected synaptic dopamine levels compared to when subjects were blind. No difference was detected between conditions; however, …
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Investigation of Spatio-Spectral Dynamics of Local Field Potentials in Parkinson’s Disease
… deficits. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as an effective neurosurgical treatment for the patients with PD where their motor symptoms cannot be controlled with medications. Accurate localization of STN is an important factor defining the efficacy of …
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Cortical - Basal Ganglia Circuits: Control of Behaviour and Alcohol Misuse
… circuitry can be subject to filtering by the subthalamic nucleus (STN), which receives direct projections from the cortex. This work first demonstrated the functional organisation of segregated intrinsic cortical – basal ganglia circuits in humans, alongside a detailed map of functional …
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Towards Closed-Loop Deep Brain Stimulation: Behavior Recognition from Human STN
… signals can be used to recognize the behaviors. Subthalamic Nucleus (STN) Local field Potential (LFP) is a great candidate signal for the neural feedback, because it can be recorded from the stimulation lead and does not require additional sensors. This thesis proposes novel detection and …
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Occulomotor Function and Locomotion in Parkinson's Disease
… with PD and deep brain stimulation: DBS) of the subthalamic nucleus. Gait parameters and turn duration improved with both levodopa therapy and DBS, but only DBS was successful in improving concurrent oculomotor function. The amplitude and velocity of the first saccade improved with DBS, while the …
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
… input to SNc-DA neurons is primarily from the subthalamic nucleus, and in PD these afferents display a higher frequency firing, as well as increased burst firing, which could cause increased excitatory activity in SNc-DA neurons. NMDA receptors (NMDARs) bind the excitatory neurotransmitter …
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Dissection of Neurons and Circuits Involved in Regulating Innate Behaviors, Movement and Higher Cognitive Functions in Mice
… ganglia, and in particular on the role of the Subthalamic Nucleus (STN) in Parkinson's Disease and Obsessive-Compulsive Disorder. I identified previously undescribed subpopulations of STN neurons, and tested their role in mediating motor, emotional and cognitive functions in mice, both in …
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Mechanisms of Deep Brain Stimulation for the Treatment of Parkinson's Disease: Evidence from Experimental and Computational Studies
… the mechanisms underlying the effectiveness of subthalamic nucleus (STN) DBS by quantifying changes in neuronal activity in the basal ganglia during both effective and ineffective DBS.</p><p>Two different approaches were adopted in this study. The first approach was the unilateral …
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Functional organisation of behavioural inhibitory control mechanisms in cortico-basal ganglia circuitry: implications for stimulant use disorder.
… frontal cortices as well as motor cortex, the subthalamic nucleus and dorsal striatum, is critical to stopping impulse control in both control and cocaine individuals. No stopping efficiency impairments were observed in the cocaine-dependent group. Nevertheless, lower structural corticostriatal …
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