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Showing 1 to 20 of 512 for “"Substitutions"”.
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Semisynthetic cytochrome c site-67 substitutions
Highly conserved tyrosine-67 of mitochondrial cytochrome $c$ is thought to be involved in important hydrogen bonding interactions in the hydrophobic heme pocket of the protein. In order to investigate the hydrogen bonding role of this residue, two site-67 analogs were prepared by semisynthetic …
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Bypassing LLM watermarks with color-aware substitutions
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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DNA polymerase interactions and their role In translesion synthesis substitutions.
… For each TLS process, multiple polymerase substitutions are necessary. To progress the polymerase research of the Trakselis laboratory, I have performed in vitro assays with archaeal enzymes to improve the understanding of regulatory mechanisms that may have evolved to limit error-prone …
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The effect of cation substitutions on the physical properties of trioctahedra micas.
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Earth and Planetary Sciences, 1971.
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Steric and Electronic Effects Induced by Ancillary Ligand Substitutions on Cyclopentadienyl Osmium Complexes
To understand these variances, the molecular geometries of several osmium(II) and osmium(IV) complexes were investigated. (C5H5)Os(dmpm)Br reacts with NaOMe in refluxing methanol to afford the monohydride compound (C5H5)Os(dmpm)H, which can be protonated with HBF 4·Et2O to afford …
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Synthesis and characterization of implants for bone substitutions made of biomedical apatites containing silicon
… powders, exhibiting multiple ionic substitutions in both cationic and anionic sites, so to simulate the chemical composition of the natural bone. Particular emphasis has been given to the effect of silicon on the chemical-physical and solubility properties of the obtained …
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Effects of amino acid residue substitutions on bicarbonate function in the plastoquinone reductase in cyanobacteria
The electron transfer at the Q$\sb{\rm A}$FeQ$\sb{\rm B}$ complex is significantly and reversibly inhibited in chloroplasts of higher plants and algae depleted of bicarbonate while no such inhibition has been observed in photosynthetic bacteria. It was observed in this study that a more than four …
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Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa
According to the Joint United Nations Programme on HIV/AIDS (UNAIDS) South Africa 2010 Country Progress report, 81% of South African children in need of antiretroviral therapy (ART) were receiving treatment which is a 20% increment in treatment access from 2008 to 2009. With increase in access to …
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Performance and Usability of Force Feedback and Auditory Substitutions in a Virtual Environment Manipulation Task
… understanding of whether or not haptics or sound substitutions improved manipulation performance or usability in VE applications. Twenty-four volunteers (12 males and 12 females) participated in a 2 (haptics) x 2 (sound) x 2 (gender) mixed factorial experiment in which they completed a VE …
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Synthesis and characterisation of d-Bi2O3 related materials stabilised by substitutions of Ca, Ga, Nb and Re.
The work reported in this thesis is based around substitutions into bismuth oxide, which has proven to be highly adaptable chemically as it can accommodate a wide variety of substituents. The synthesis and characterisation of stabilised \(\delta\)-Bi\(_2\)O\(_3\) related materials containing small …
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Effect of rare and common single amino acid substitutions on DISC1 subcellular targeting and functional interaction with ATF4
… of a panel of common and rare single amino acid substitutions on DISC1 subcellular targeting, establishing that the rare mutation R37W and the common variant L607F disrupt DISC1 nuclear targeting in a dominant-negative fashion. This finding predicts that DISC1 nuclear expression is severely …
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Lithiation of Oxy-Arenes; New Methodology for Electrophilic Aromatic Substitutions: Attempted Synthesis of Thiaheptalenes and Heterocyclic Pyrene Systems
Lithiation of oxy-arenes was studied. The lithiation of 4-hydroxyphenanthrene with 2 eq. of n-butyllithium/TMEDA in cyclohexane at 23(DEGREES)C occurs completely at the 5-position, although the 5-position is the most hindered position in the 4-hydroxyphenanthrene. By contrast, the lithiation of …
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A Method Based on Conserved Multiple Amino Acid Properties to Predict Amino Acid Substitutions Which Maintain the Protein Structure
… AMINO ACID PROPERTIES TO PREDICT AMINO ACID SUBSTITUTIONS WHICH MAINTAIN THE PROTEIN STRUCTURE Avinash M. Baktula September 16, 2004 1-117 Directed by: Claire A. Rinehart, Doug McElroy and Sigrid Jacobshagen Department of Biology Western Kentucky University Proteins often contain several …
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Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency
… analogs with regioisomeric substitutions, modified linkers and bioisoteric replacements (general structure <strong>I</strong>) for selective uptake, and inhibition of one or more enzymes in the de novo purine and/or pyrimidine biosynthetic pathway. The present work identified …
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Directed Ortho-Metalations of Benzyl Alcohols, Arenesulfonic Acids, and Thiophenol: New Methodology for Electrophilic Aromatic Substitutions and the Preparation of New Sulfuranes
Dilithio derivative I is used in the preparation of optically active monocyclic dialkoxysulfurane II and the analogous chlorosulfurane and trifluoromethanesulfonate. Examinations of the possible use
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Kinetics of the ligand exchange reactions between bidentate ligands and rriethylenetetramine nickelate (II) and synthesis of boron (III) subphthalocyanines with various boron substitutions
<p>Part 1. The kinetics of the ligand exchange reaction between 5-methyl-1,10-phenanthroline and triethylenetetramine nickel (II) were studied spectrophotometrically over the pH range of 5.2 to 8.0 at 25oC. A ternary complex Ni(Trien)(5MP) forms within a few seconds and subsequently reacts with 5MP …
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Azotobacter vinelandii Nitrogenase: Effect of Amino-Acid Substitutions at the Alpha Gln-191 Residue of the MoFe Protein on Substrate Reduction and CO Inhibition
… the pH and activity studies indicate that the substitutions on the MoFe protein have an effect on the contribution of the responsible acid-base group(s) involved in proton transfer for H+- and C2H2-reduction. Furthermore, the inhibition by CO of hydrogen evolution by these altered MoFe proteins …
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Thermische Tieftemperatureigenschaften von Seltenerd-Übergangsmetall-Borkarbiden
… caused by stoichiometric variations and substitutions of the rare earth element or the transition metal, on the thermal and superconducting low-temperature properties is investigated. The structural disorder results in the reduction of the superconducting transition temperature Tc, of the …
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