Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 128 for “"Substantia nigra"”.
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) have a key role in regulation of voluntary movement control. Their death is a hallmark of Parkinson’s disease, characterised by inhibited motor control, including muscle rigidity and tremor. Excitatory input to SNc-DA neurons is …
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Wirkung von Cannabinoiden auf die Neurotransmission im Corpus striatum und in der Substantia nigra pars reticulata
… Systems: im Corpus striatum und in der Substantia nigra pars reticulata (SNR). Beide Kerne enthalten viele CB1-Cannabinoidrezeptoren – das anatomische Substrat einer Cannabinoidwirkung ist also gegeben. Schnitte wurden aus Rattengehirn hergestellt und superfundiert. Neuronale Übertragung …
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Quantifizierung und zelluläre Lokalisation von Eisen in der Substantia nigra bei Patienten mit Parkinsonscher Erkrankung und gesunden Kontrollen
… und zelluläre Lokalisation von Eisen in der Substantia nigra bei Patienten mit Parkinsonscher Erkrankung und gesunden Kontrollen eingereicht von Isabel Weigelt angefertigt an der Medizinischen Fakultät der Universität Leipzig Paul Flechsig Institut für Hirnforschung, Abteilung Molekulare und …
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Pontomedullary reticular formation neurones : a study of microanatomy, transmitter sensitivity and connections from the substantia nigra pars reticulata
… and also the connections between the substantia nigra pars reticulata (SNr) and the PMRF in the rat. The anatomical distribution of the population of PMRF neurones was determined by combining physiological identification with electrical stimulation and retrograde HRP tract-tracing. A …
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Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease
… of dopamine (DA)-producing neurons of the Substantia Nigra pars compacta (SNc). However, PD patients also suffer from many non-motor symptoms (NMS; eg. sleep disturbance, autonomic dysfunction, depression and anxiety), which cause significant disability and impair quality of life. These NMS …
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The role of copper in Parkinson's disease
… been consistently reported in the degenerating substantia nigra in Parkinson s disease, but the cause, and functional consequences, of this decrease are unknown. This thesis aimed to investigate neuronal copper levels and potential changes in copper transport in the Parkinson s disease brain to …
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Ossitocina nella Sostanza Nera del ratto: azione sull'attività locomotoria e interazione con i neuroni dopaminergici, glutammatergici e GABAergici nigrali
… oxytocin might act to produce this effect. The substantia nigra, a mesencephalic structure which is part of the basal ganglia, a group of interconnected nuclei involved in motor and non-motor functions, receives oxytocinergic projections from the parvocellular compartment of the paraventricular …
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Neuroprotective effect of mesenchymal stem cells in neurodegenerative disease : focusing on Parkinsonian disease
… of TH- and NeuN-immunoreactive cells in the substantia nigra and the striatum, respectively. Additionally, hMSC treatment significantly decreased Iba-1, GFAP and increased Calbindine immunoreactive cells in the substantia nigra and the striatum. Behavioral analysis showed that the decent …
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Preclinical evaluation of a novel AAV-GDF5 vector in a 6-OHDA model of Parkinson’s disease and evaluation of the effect of 6-OHDA on the expression of HDACs
… located regions of the brain as the striatum or substantia nigra. Directly administered proteins will be broken down, meaning that such an intervention would have short-lived benefits. For this reason, the use of viral vectors to deliver neurotrophic factor genes has become a popular alternative, …
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Quantifying Neuromelanin Content Across Varying Magnetic Field Strengths: A Comparative Analysis
… dark pigment molecule that is found in the substantia nigra of the human brain. Due to its paramagnetic nature, NM can be imaged using MRI in the form of neuromelanin sensitive contrast. This method, known as Neuromelanin Sensitive Magnetic Resonance Imaging (NM-MRI) allows non-invasive …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… and oxidative DNA damage in the MPTP-treated substantia nigra. Additional immunohistochemical staining also showed that MPTP induced glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) in the substantia nigra (SN). Interestingly, treatment with EP …
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Derivation of next generation research models of Parkinson’s disease
… the degeneration of dopaminergic neurons in the substantia nigra region of the midbrain and the presence of intracellular inclusions, notably Lewy bodies composed of the alpha-synuclein protein (encoded by the SNCA gene), in the surviving neurons. The precise molecular and cellular mechanisms …
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Isolierung und Charakterisierung Neuromelanin-assoziierter Proteine aus Neuromelanin-Granula des menschlichen Gehirns mittels subzellulärer Proteomanalyse
… Ursache für die dunkle Farbgebung der humanen Substantia nigra pars compacta ist. Eine Beteiligung von Neuromelanin an den pathobiochemischen Ereignissen bei Parkinson-Krankheit erklärt das klinische Interesse an Neuromelanin. Die Untersuchungsmöglichkeiten von Neuromelanin sind limitiert: …
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STUDIO DEGLI ADDOTTI CATECOLAMMINE-PROTEINE IN SOSTANZA NERA E NEL PUTAMEN UMANI
… the degeneration of dopaminergic neurons in the substantia nigra and locus coeruleus. Neurons of both areas contain a melanic pigment called neuromelanin. This pigment accumulates linearly during aging and originates from an excess of free cytosolic dopamine. Dopamine, like other catecholamines, …
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Pacemaking Neurons in the study of Parkinson’s Disease
… failure that leads to severe degeneration in the substantia nigra , a locus in the mid-brain. Traditional approaches tend to focus on isolated sub-components of the pathogenic pathways. However, such an approach may be inadequate to describe the pathogenesis. Substantia nigra neurons function on …
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Engrailed genes are cell autonomously required for the survival of the mesencephalic dopaminergic neurons
The dopaminergic neurons of the substantia nigra and ventral tegmentum are the main source of dopamine in the central nervous system. The progressive loss of dopaminergic neurons in the substantia nigra compacta over several decades leads to one of the most prominent human neurodegenerative …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… progressive loss of dopaminergic neurones in the substantia nigra, have linked α-synuclein toxicity and oxidative stress to the pathogenesis of the disorder. Interestingly HDAC-Is have been shown to prevent α-synuclein and 1-methyl-4-phenylpyridinium (MPP+)-induced cellular toxicity in vitro, but …
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The role of adaptive immunity in Parkinson's pathology following traumatic brain injury
… Quantification of dopaminergic neurons in the substantia nigra showed significant cell death at 90 days post-injury compared to sham controls, with associated alterations in striatal neurotransmitter levels, like dopamine, leading to behavioral phenotypes. At that same time point, CD8+ T cells …
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An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation
… and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta (SNc) to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a novel, non-genetic ultrasound platform for spatially localized neural stimulation.
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