Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Substantia Nigra pars Compacta"”.
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) have a key role in regulation of voluntary movement control. Their death is a hallmark of Parkinson’s disease, characterised by inhibited motor control, including muscle rigidity and tremor. Excitatory input to SNc-DA neurons is …
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An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation
… and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta (SNc) to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a novel, non-genetic ultrasound platform for spatially localized neural stimulation.
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Auswirkungen des LRRK2-Knockdown durch RNA-Interferenz auf die murine dopaminerge Zelllinie MN9D
… der spezifischen Neurodegeneration in der Substantia nigra Pars Compacta (SNpc) und somit zur Idiopathischen Parkinsonssyndrom führen, ist mit der Hoffnung auf kausale und kurative Therapieansätze verbunden. In dieser medizinischen Doktorarbeit soll daher versucht werden, die biologische …
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Cell model of DJ-1-associated Parkinson’s Disease
… from dopaminergic neuronal death in the substantia nigra pars compacta leading to subsequent decreased striatal dopamine levels. The majority of PD cases are diagnosed as sporadic in nature, however 10% - 15% of patients show a positive family history of the disease. While many genes have …
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). Dopamine neurons have been shown to exhibit mitochondrial dysfunction, oxidative stress and misfolded protein aggregation in patients with PD. Since ELS has been shown to negatively affect the nigrostriatal …
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READING THROUGH THE BUILDING BLOCKS OF THE GENOME: EXONIC VARIATION IN PARKINSON'S DISEASE
… selective loss of dopaminergic neurons in the substantia nigra pars compacta. Treatments aimed at compensating dopamine deficit can alleviate the major motor symptoms and enhance the patients quality of life, but finally are not able to halt or slow down disease progression. Therefore, there is …
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FUNCTIONAL ROLES OF MIDBRAIN DOPAMINE NEURONS IN ASSOCIATIVE LEARNING
… evidence for a projection from the SC to substantia nigra pars compacta and physiological findings showing that SC activity can drive phasic dopamine activity. This dissertation provides a critical test of these competing hypotheses through in vivo recording from dopamine neurons in the …
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Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons
… of dopaminergic neurons (DNs) in the midbrain (substantia nigra pars compacta), which innervate the striatum. Although initially efficacious, the therapeutic effect of various anti-parkinsonian pharmacological treatments is limited to five to ten years. Hence, the new therapeutic strategies for …
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Isolierung und Charakterisierung Neuromelanin-assoziierter Proteine aus Neuromelanin-Granula des menschlichen Gehirns mittels subzellulärer Proteomanalyse
… Ursache für die dunkle Farbgebung der humanen Substantia nigra pars compacta ist. Eine Beteiligung von Neuromelanin an den pathobiochemischen Ereignissen bei Parkinson-Krankheit erklärt das klinische Interesse an Neuromelanin. Die Untersuchungsmöglichkeiten von Neuromelanin sind limitiert: …
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A NOVEL RIT2-LRRK2 AXIS MODULATES LYSOSOME FUNCTION: INSIGHT FOR PARKINSON'S DISEASE PATHOPHYSIOLOGY
… sono ridotti nei neuroni dopaminergici della substantia nigra pars compacta (SNpc) e in modelli in vitro che in vivo di PD. L’overespressione di Rit2 in cellule di neuroblastoma esprimenti G2019S LRRK2 ha revertito difetti lisosomiali e diminuito l’accumulo di αSyn, mostrando un effetto simile …
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Progress Towards Development Of Multifunctional, Dopamine D2/d3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease
… through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of motor function. Common symptoms of PD include resting tremor, muscular rigidity, bradykinesia …
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INVESTIGATION OF ALPHA-SYNUCLEIN/TUBULIN INTERACTION IN PRESYNAPTIC MICROTUBULE DYNAMICS IN DOPAMINERGIC NEURONS
… and loss of the dopaminergic (DA) neurons of the substantia nigra pars compacta (SNpc) in Parkinson’s disease (PD) are still unknown. Among them, α-synuclein aggregation, mitochondrial impairment, increase oxidative stress and synaptic dysfunction are often indicated as culprits, although it is …
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H5N1 Influenza Virus Induces a Parkinsonian Pathology
… the pathology worsened with age, we examined: 1) substantia nigra pars compacta (SNpc) tyrosine hydroxylase positive dopaminergic neuron number and striatal dopamine and its metabolites contents through 90 days post infection (dpi), 2) examined the inflammatory effect of infection by …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… progressive loss of dopaminergic neurones in the substantia nigra, have linked α-synuclein toxicity and oxidative stress to the pathogenesis of the disorder. Interestingly HDAC-Is have been shown to prevent α-synuclein and 1-methyl-4-phenylpyridinium (MPP+)-induced cellular toxicity in vitro, but …
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Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
… progressiven Verlust dopaminerger Neurone in der substantia nigra pars compacta (SNpc). Der glial cell line-derived neurotrophic factor (GDNF) ist in präklinischen Studien als wichtiger Differenzierungs- und Überlebensfaktor für dopaminerge Neurone des Mittelhirnes identifiziert worden, jedoch hat …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… by a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A number of studies have implicated chronic inflammation in the pathophysiology of PD; however, it is unclear which inflammatory mechanisms directly contribute to neuronal loss in PD. A number of cytokines, …
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Functional Dissection of Brainstem Circuitry
… of the midbrain (the ventral tegmental area/substantia nigra pars compacta and dorsal raphe, respectively), as they are essential for key survival behaviors, such as feeding and locomotion. These populations of neurons are therefore ideal for studying the generation of purposive behaviors in …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… activation and phenotype was investigated in the substantia nigra pars compacta (SNc) via the evaluation of pro- (TNF-α and iNOS) and anti-inflammatory (CD206) molecules, with fluorescent immunohistochemistry. Moreover, cultured murine microglia MMGT12 were treated with MDG548 in association with …
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Characterisation of a protease-dependent gene regulation system for gene therapy applications
… control of the regulatory system to the rat substantia nigra pars compacta, expression of GFP was induced in response to cellular stress initiated in the striatum. In the final study the protective efficacy of the anti-apoptotic gene X-linked Inhibitor of Apoptosis Protein (XIAP) under the …
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Effect of Parkinson’s disease-related alpha-synuclein abnormalities on the maturation of distinct iPSC-derived neuronal populations
… of the midbrain dopaminergic neurons from the substantia nigra pars compacta. Lewy pathology mainly consists of filamentous aggregated alpha-synuclein and familial forms of PD can be caused by genetic alternations in the SNCA gene encoding alpha-synuclein. Alpha-synuclein is primarily localised …
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