Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 651 for “"Subcellular"”.
-
Mechanism and Regulation of ERK2 Subcellular Localization
… assays of phosphorylated ERK1/2 show discrete subcellular localization patterns in response to different stimuli that are independent of the level of ERK1/2 activation. Under conditions in which ERK1/2 is concentrated in the cytoplasm, the nuclear substrate of the kinase, c-Fos, is not …
-
Quantitative analysis of subcellular biomechanics and mechanotransduction
… necessary to achieve a detailed understanding of subcellular mechanics. In this work, we present novel methods to independently quantify cytoskeletal displacements, mechanical coupling between the cytoskeleton and the extracellular matrix, and nuclear mechanics based on high resolution tracking of …
-
Subcellular Localization of Nicotiana tabacum TGA Transcription Factors
Die Salicylsäure (SA) ist ein wichtiges Signalmolekül bei der Regulation der pflanzlichen Pathogenabwehr. as-1-ähnliche cis-Elemente in den Promotoren von vielen Abwehrgenen vermitteln SA- und auch Auxin-induzierbare Genexpression. Diese Elemente werden vom ASF-1/SARP-Proteinkomplex erkannt, dessen …
-
Regulated Subcellular Distribution of Constitutive Androstane Receptor (Car)
… in PB-treated animals. Regulation of the subcellular distribution of CAR is much more complicated than generally thought and might involve multiple regulatory factors and signal motifs.
-
Absorption, transport, and subcellular distribution of beta-carotene
… concerning carotenoid absorption, transport, and subcellular distribution are not well defined.
-
Scalable Subcellular Resolution Mapping of the Human Brain
A detailed understanding of the anatomical and molecular architectures of cells and their system-wide connectivity is essential for interrogating system function and dysfunction. Extensive efforts have been made toward characterizing cells through various omics approaches, and have established …
-
Hidden Markov model analysis of subcellular particle trajectories
… ow in a particular direction? Understanding how subcellular particles move in a cell will reveal fundamental principles of cell biology and biochemistry, and is a necessary prerequisite to synthetically engineering such processes. We investigate the application of several variants of hidden …
-
Role of Subcellular Differentiation in Plant Disease Resistance
… so that only a few cells were sacrificed. The subcellular localization of the defense-specific HMG2 isoform was determined by tagging tomato hmg2 with a c-myc epitope, and constitutively expressing the construct in transgenic tobacco plants. In non-induced leaves, MYC-HMG2 was found localized …
-
Methods for Identifying Subcellular Targeting Ligands and Selected Applications
Subcellular localization plays an essential role in targeting drug therapies as generally the pro-drug or linker relies on physical conditions of a particular subcellular compartment to function. We developed two methods that allow for selecting targeting ligands that both internalize specifically …
-
Inquiries into the subcellular localization of the glucocorticoid receptor.
… assay was employed to characterize the subcellular localization of a series of GR mutants effectively truncating, deleting or mutating specific regions of the receptor N-terminus. In the first part of my study, I delimited a specific region of GR (amino acids 100--200 of the N-terminus) …
-
Investigation into the Akirin Subcellular Localization and Developmental Interactions
… defects. This investigation focused on both the subcellular localization of Akirin based on a putative nuclear localization signal and the genetic interaction between Akirin and the Nucleosome Remodeling Deacetylase (NuRD) complex. Through transfection of <em>Drosophila</em> S2 cells with Akirin …
-
Polyribonucleotide Synthesis in a Subcellular Fraction of Escherichia Coli
Made available in DSpace on 2014-12-05T21:45:33Z (GMT). No. of bitstreams: 1 6100200.pdf: 3716606 bytes, checksum: 71a4ee01cf88f443fb44e12f140a4956 (MD5) Previous issue date: 1960
-
Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
<p>Activation of Rho family small G proteins is thought to be a critical event in breast cancer development and metastatic progression. Rho protein activation is stimulated by a family of enzymes known as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 …
-
Investigating Subcellular Thiol Redox Chemistry With Gfp-Based Redox Sensors
… our lab was the first to demonstrate that this subcellular compartment is more oxidizing than the cytosol and mitochondrial matrix. Glutathione reductase (Glr1) is responsible for the regeneration of GSH to maintain the reduced environment. Experiments show that expressing IMS-localized Glr1 …
-
Subcellular Localization and Activity of the Multidrug Resistance Protein 1
<p>Multi-drug resistance or MDR is a major impediment to the successful administration of chemotherapy. Broadly defined, the term MDR applies to any mechanism the cell uses to counter the effects of chemotherapeutic agents, protecting the cell at once against the toxicity of many, structurally …
-
Dynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
… of the adipocyte insulin-response. First, the subcellular 3T3-L1 adipocyte proteome was mapped under baseline and insulin- stimulated (100 nM, 30 min) conditions using the Localisation of Organelle Proteins by Isotopic Tagging after Differential UltraCentrifugation (LOPIT-DC) method. Over 4000 …
-
Leucyl-tRNA synthetase: dynamic subcellular relocalization and drug resistance mechanism
"The family of aminoacyl-tRNA synthetases (aaRS) are essential to all living cells. They are fundamental to setting the genetic code during protein synthesis by charging tRNA with a specific amino acid. As such, they have been selected by the pharmaceutical industries as optimal targets. A new …
-
Subcellular Distribution and Pharmacokinetics of Dihydrostreptomycin in Rats and Swine
Made available in DSpace on 2014-12-11T21:33:46Z (GMT). No. of bitstreams: 1 7317118.pdf: 4653745 bytes, checksum: 74e1a13f7da6032148a33040b979fca6 (MD5) Previous issue date: 1972
-
Multiscale MALDI mass spectrometry for tissue, cellular, and subcellular lipidomics
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
-
Subcellular localization and visualization of RecA and ImuAʹ in mycobacteria
… to explore the dynamics of their expression and subcellular localization within live Msm cells. To this end, fluorescently tagged versions of ImuAʹ and RecA were constructed and shown to retain functional activity in UV-induced mutagenesis but not survival of mitomycin C (MMC) treatment. The …
Page 1 of 33