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Showing 1 to 6 of 6 for “"Structure determination of proteins"”.
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Structure determination of proteins and peptides in solution: simulation, chirality and NMR studies
The study of protein fold is a central problem in life science, leading in the last years to several attempts for improving our knowledge of the protein structures. In this thesis this challenging problem is tackled by means of molecular dynamics, chirality and NMR studies. In the last decades, …
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Structure determination of proteins and protein aggregates by magic-angle spinning solid-state NMR
Solid state NMR (SSNMR) is a structure determination technique uniquely suited to study protein aggregates and fibrils. Unlike solution NMR or X-ray crystallography, SSNMR can obtain atomic resolution structural information on samples of protein fibrils which are insoluble and do not produce X-ray …
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Methodology and applications of high resolution solid-state NMR to structure determination of proteins
A number of methodological developments and applications of solid-state NMR for assignment and high resolution structure determination of microcrystalline proteins and amyloid fibrils are presented. Magic angle spinning spectroscopy on uniformly and selectively "C and '5N labeled samples is …
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Biomolecular Solid-State Nuclear Magnetic Resonance Methods for Spectral Assignment and High-Resolution Structure Determination of Proteins
… (SSNMR) experiments for the elucidation of structure in microcrystalline proteins are presented, utilizing the streptococcal beta-1 immunoglobulin binding domain of protein G (GB1) as a model protein. Complete 13C and 15N chemical shifts are presented based on 2D 13C-13C, 15N-13C and 3D …
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X-ray compatible microfluidic platforms for studying protein structure and function
If you can look into the seeds of time, And say which grain will grow and which will not. - Macbeth. Act I, Scene 3. Knowledge of the three dimensional structure of a protein provides insight into its mechanism, as well as into potential sites for drug targeting. Often these insights provide …