Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 192 for “"Structure determination"”.
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Protein structure determination using evolutionary information
… inference of the underlying physical molecular structure and interactions. Recently, it was shown that a global statistical model of a protein family that captures both conservation and coevolution patterns in the family, to possess such quality. The strength of co-evolution term is correlated …
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Structure Determination of Natural Product Biosynthesis Enzymes
… work describes the CalS10, DynU16 and AtmM structures determined by X-ray crystallography and kinetic parameters expanding our enzymatic toolkit for NP biosynthesis.
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Machine learning for cryo-EM structure determination
… image processing have enabled the structural determination of many macromolecules that were previously intractable by other methods. At the same time, breakthroughs in machine learning—most notably AlphaFold2—have driven further progress across structural biology. During my PhD, I developed …
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Structure determination of glycoproteins by mass spectrometry
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Structure determination of piezoelectric materials at extreme conditions
Diese Arbeit präsentiert Ergebnisse an piezoelektrischen Materialien aus der Langasitfamilie, die unter extremen Bedingungen untersucht wurden. Die Einkristalle aus dieser Familie, vor allem La3Nb0.5Ga5.5O14 (LNG) und La3Ta0.5Ga5.5O14 (LTG), sind vielversprechende Materialien für Oberflächenwellen …
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Advances in oxygen-17 NMR for biological structure determination
The determination of the structures of biological systems, such as, fibril-forming peptides and proteins, membrane proteins, and viruses, by solid-state nuclear magnetic resonance (NMR) spectroscopy has materialized as an important field due to the high-resolution details that the technique …
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Crystal Growth, Structure Determination and Physical Property of Complex Oxides
… significant in order to allow for the study of structure-property relationships. We aim to discover new materials via the growth of single crystals. Flux crystal growth has several advantages over other methods, including low reaction temperatures and easy reaction setup. Novel Fe, Co, Rh, Hf …
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Novel Algorithms for Automated NMR Assignment and Protein Structure Determination
<p>High-throughput structure determination based on solution nuclear magnetic resonance (NMR) spectroscopy plays an important role in structural genomics. Unfortunately, current NMR structure determination is still limited by the lengthy time required to process and analyze the experimental data. A …
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Solid state nuclear magnetic resonance methodology for biomolecular structure determination
Several developments in solid state nuclear magnetic resonance (SSNMR) spectroscopy methods are presented. All studies are performed with magic angle spinning (MAS) and high-power proton decoupling, for optimal sensitivity and resolution. Chemical shift are assigned by multi-dimensional correlation …
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Structure Determination of Viscotoxin A1, Tendamistat and Tri Peptidyl peptidase-I
Die vorliegende Arbeit beschreibt sowohl die Methoden, die benutzt wurden, um die Kristallstrukturen der genannten Proteine mithilfe von experimenteller Phasenbestimmung zu lösen, als auch eine Analyse ihrer Struktur.Viscotoxin gehört zur Familie der α- und β-Thionine, die zytotoxische Aktivität …
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Techniques of Geophysical Prospection as applied to Near Surface Structure Determination
This thesis is an account of the research carried out by the author as a member of the Postgraduate School of Applied Physics at the University, during the years 1967 to 1970. The induced polarization and earth resistivity techniques of geophysical prospection are considered in detail, with respect …
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Applications of DNP and solid-state NMR for protein structure determination
… is a developing method for determining the structures and studying the dynamics and functions of biological molecules. This method is particularly important for systems, such as amyloidogenic fibrous proteins, that do not crystallize or dissolve well and are therefore not amendable to X-ray …
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Ab initio calculations of NMR chemical shifts for structure determination in biology
… nuclear Magnetic Resonance chemical shifts to structure determination in Biology. We investigate and summarise the most important structural contributions to the chemical shift. Even though the NMR chemical shift has direct relation to the global structure it is shown that there are two main …
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Mesophase-based approaches for on-chip membrane protein crystallization and structure determination
… new and improved therapeutics. Detailed spatial structures of proteins are typically obtained from crystal X-ray diffraction data. Crystallizing membrane proteins, however, is extremely difficult due to their amphiphilic properties that affect their stability in aqueous solutions. The …
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